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anti-EPX antibody :: Mouse anti-Human Eosinophil Peroxidase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601662 anti-EPX antibody
Unit / Price
0.1 mL  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Eosinophil Peroxidase (EPX), Monoclonal Antibody

 Also Known As   

Eosinophil Peroxidase

 Product Synonym Names    Anti -Eosinophil Peroxidase
 Product Gene Name   

anti-EPX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (56270089..56282535). Location: 17q23.1
 OMIM    131399
 3D Structure    ModBase 3D Structure for P11678
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2Q2224
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human eosinophil peroxidase from eosinophils among peripheral blood cells.
 Purity/Purification    Ascites
 Form/Format    Supplied as a liquid. No preservative added.
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 Immunogen    Human eosinophil peroxidase.
 Control No.    C15012202
 Revision No.    070910
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-EPX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-EPX antibody

   Eosinophil peroxidase is believed to play an important role in eosinophil function and perhaps endothelial injury in hypereosinophilic states.
 Product Categories/Family for anti-EPX antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-EPX antibody   

ELISA (EL/EIA)
Suitable for ELISA. Other applications have not been tested.

 Application Notes for anti-EPX antibody    Suitable for use in ELISA.
Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for EPX. It may not necessarily be applicable to this product.
 NCBI GI #    4503595
 NCBI GeneID    8288
 NCBI Accession #    NP_000493.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000502.4 [Other Products]
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 UniProt Primary Accession #    P11678 [Other Products]
 UniProt Secondary Accession #    Q4TVP3 [Other Products]
 UniProt Related Accession #    P11678 [Other Products]
 Molecular Weight    81,040 Da [Similar Products]
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 NCBI Official Full Name    eosinophil peroxidase preproprotein
 NCBI Official Synonym Full Names    eosinophil peroxidase
 NCBI Official Symbol    EPX [Similar Products]
 NCBI Official Synonym Symbols   
EPO; EPP; EPX-PEN
[Similar Products]
 NCBI Protein Information    eosinophil peroxidase
 UniProt Protein Name    Eosinophil peroxidase
 Protein Family    Eosinophil peroxidase
 UniProt Gene Name    EPX [Similar Products]
 UniProt Synonym Gene Names    EPER; EPO; EPP [Similar Products]
 UniProt Entry Name    PERE_HUMAN
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 NCBI Summary for EPX    This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq]
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 UniProt Comments for EPX    EPX: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD). EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Belongs to the peroxidase family. XPO subfamily.

Protein type: Oxidoreductase; EC 1.11.1.7

Chromosomal Location of Human Ortholog: 17q23.1

Molecular Function: peroxidase activity; metal ion binding; heme binding

Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; hydrogen peroxide catabolic process; negative regulation of interleukin-5 production; response to oxidative stress; defense response to nematode

Disease: Eosinophil Peroxidase Deficiency
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 Research Articles on EPX    1. EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Eosinophil Peroxidase
 Catalog #  Product Name  Catalog #  Product Name
 MBS083672  Cat Eosinophil Peroxidase ELISA Kit  MBS844058  Eosinophil Peroxidase, Human Eosinophils
 MBS173121  Eosinophil Peroxidase (EPO), Human  MBS088526  Camel Eosinophil Peroxidase ELISA Kit
 MBS2884409  Mouse Eosinophil peroxidase ELISA Kit  MBS057449  Bovine Eosinophil Peroxidase ELISA Kit
 MBS7224430  Human Eosinophil peroxidase (EPX) ELISA Kit  MBS2887189  Pig Eosinophil peroxidase ELISA Kit
 MBS653638  Eosinophil peroxidase, Human  MBS319509  HUMAN EOSINOPHIL PEROXIDASE
Pathways associated with anti-EPX antibodyDiseases associated with anti-EPX antibody
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Disease Name  Pubmed Publications
 Asthma Antibodies  >82 publications with EPX and Asthma
 Inflammation Antibodies  >81 publications with EPX and Inflammation
 Eosinophilia Antibodies  >18 publications with EPX and Eosinophilia
 Rhinitis Antibodies  >12 publications with EPX and Rhinitis
 Colitis Antibodies  >10 publications with EPX and Colitis
 Inflammatory Bowel Diseases Antibodies  >8 publications with EPX and Inflammatory Bowel Diseases
 Bronchial Hyperreactivity Antibodies  >8 publications with EPX and Bronchial Hyperreactivity
 Recurrence Antibodies  >4 publications with EPX and Recurrence
 Asthma, Exercise-Induced Antibodies  >3 publications with EPX and Asthma, Exercise-Induced
 Adenocarcinoma Antibodies  >3 publications with EPX and Adenocarcinoma
Organs/Tissues associated with anti-EPX antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with EPX and Blood
 Bone Antibodies  >3 publications with EPX and Bone
 Bone Marrow Antibodies  >2 publications with EPX and Bone Marrow
 Mixed Antibodies  >1 publications with EPX and Mixed
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