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anti-EpCAM antibody :: Mouse anti-Human EpCAM Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831272
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EpCAM, Monoclonal Antibody

 Also Known As   

EpCAM antibody

 Product Synonym Names    Monoclonal EpCAM; Anti-EpCAM; Epithelial Specific Antigen; Ep-CAM; EGP40; ESA
 Product Gene Name   

anti-EpCAM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    185535
 3D Structure    ModBase 3D Structure for P16422
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    4G10
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    EpCAM antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    EpCAM is a 40 kDa transmembrane epithelial glycoprotein. It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. It reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
 Immunogen    EpCAM antibody was raised in mouse using a recombinant protein expressed in E Coli corresponding to amino acids 24-265 of human EpCAM as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-EpCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EpCAM antibody

   Mouse monoclonal EpCAM antibody
 Product Categories/Family for anti-EpCAM antibody    Cancer
 Applications Tested/Suitable for anti-EpCAM antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-EpCAM antibody    IHC: 1:50
IF: 1:100
WB: 1:500
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 Western Blot (WB) of anti-EpCAM antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant EpCAM protein (Right) or empty vector (Left) detected with EpCAM antibody
anti-EpCAM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EpCAM antibody    Immunohistochemical analysis of EpCAM protein in paraffin embedded Human kidney using EpCAM antibody
anti-EpCAM antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EpCAM. It may not necessarily be applicable to this product.
 NCBI GI #    218505670
 NCBI GeneID    4072
 NCBI Accession #    NP_002345.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002354.2 [Other Products]
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 UniProt Primary Accession #    P16422 [Other Products]
 UniProt Secondary Accession #    P18180; Q6FG26; Q6FG49; Q96C47; Q9UCD0 [Other Products]
 UniProt Related Accession #    P16422 [Other Products]
 Molecular Weight    34,932 Da
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 NCBI Official Full Name    epithelial cell adhesion molecule
 NCBI Official Synonym Full Names    epithelial cell adhesion molecule
 NCBI Official Symbol    EPCAM [Similar Products]
 NCBI Official Synonym Symbols   
ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
[Similar Products]
 NCBI Protein Information    epithelial cell adhesion molecule
 UniProt Protein Name    Epithelial cell adhesion molecule
 UniProt Synonym Protein Names   
Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326
 Protein Family    Epithelial cell adhesion molecule
 UniProt Gene Name    EPCAM [Similar Products]
 UniProt Synonym Gene Names    GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314 [Similar Products]
 UniProt Entry Name    EPCAM_HUMAN
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 NCBI Summary for EpCAM    This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
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 UniProt Comments for EpCAM    EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cell surface; tight junction; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; lateral plasma membrane

Molecular Function: protein binding; protein complex binding

Biological Process: ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation

Disease: Diarrhea 5, With Tufting Enteropathy, Congenital; Colorectal Cancer, Hereditary Nonpolyposis, Type 8
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 Research Articles on EpCAM    1. Results show that high expression of nuclear Epithelial-intracellular domain of EpCAM was more frequent in breast cancers compared to normal tissues and correlated with poor prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EpCAM antibodyDiseases associated with anti-EpCAM antibody
 Reference Product  PubMed Publications
 MYC antibody  >32 publications with EpCAM and MYC
 CCND1 antibody  >19 publications with EpCAM and CCND1
 PTPRC antibody  >15 publications with EpCAM and PTPRC
 CLDN7 antibody  >15 publications with EpCAM and CLDN7
 CDH1 antibody  >14 publications with EpCAM and CDH1
 TP53 antibody  >10 publications with EpCAM and TP53
 TSPAN8 antibody  >6 publications with EpCAM and TSPAN8
 PROM1 antibody  >4 publications with EpCAM and PROM1
 GPNMB antibody  >1 publications with EpCAM and GPNMB
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >624 publications with EpCAM and Carcinoma
 Neoplasm Metastasis Antibodies  >371 publications with EpCAM and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >280 publications with EpCAM and Adenocarcinoma
 Breast Neoplasms Antibodies  >223 publications with EpCAM and Breast Neoplasms
 Liver Neoplasms Antibodies  >173 publications with EpCAM and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >152 publications with EpCAM and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >122 publications with EpCAM and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >120 publications with EpCAM and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >93 publications with EpCAM and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >86 publications with EpCAM and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-EpCAM antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >494 publications with EpCAM and Blood
 Liver Antibodies  >310 publications with EpCAM and Liver
 Lung Antibodies  >188 publications with EpCAM and Lung
 Prostate Antibodies  >110 publications with EpCAM and Prostate
 Lymph Node Antibodies  >72 publications with EpCAM and Lymph Node
 Vascular Antibodies  >60 publications with EpCAM and Vascular
 Ascites Antibodies  >59 publications with EpCAM and Ascites
 Stomach Antibodies  >57 publications with EpCAM and Stomach
 Intestine Antibodies  >53 publications with EpCAM and Intestine
 Kidney Antibodies  >44 publications with EpCAM and Kidney
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