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anti-EphA1 antibody :: Mouse anti-Human EphA1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850785
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EphA1, Monoclonal Antibody

 Also Known As   

EphA1 Antibody

 Product Synonym Names    EPH; EPHT; EPHT1
 Product Gene Name   

anti-EphA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179610
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 Clonality    Monoclonal
 Clone Number    5D2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Purified antibody in PBS containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of EphA1 expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C
 Other Notes    Small volumes of anti-EphA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-EphA1 antibody

   Background: EPH receptor A1 (EphA1), with 976-amino acid protein(about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date and their ligands, the ephrins,can be subdivided into two major subclasses, ephrin-A and ephrin-B. Interaction of Eph receptor tyrosine kinases with their membrane bound ephrin ligands initiates bidirectional signaling events that regulate cell migratory and adhesive behavior, particularly in the nervous system. They have been implicated in various developmental processes, including axonal guidance, angiogenesis, morphogenesis and carcinogenesis.
 Product Categories/Family for anti-EphA1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-EphA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-EphA1 antibody    WB: 1/500 - 1/2000, IHC:1/200 - 1/1000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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 Testing Data of anti-EphA1 antibody    Figure 1. Western blot analysis using EphA1 mouse mAb against A549 (1) and Hela (2) cell lysate.
anti-EphA1 antibody Testing Data image
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 Testing Data #2 of anti-EphA1 antibody    Figure 2. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (left) and breast carcinoma (right), showing cytoplasmic localization using EphA1 mouse mAb with DAB staining.
anti-EphA1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for EphA1. It may not necessarily be applicable to this product.
 NCBI GI #    221316650
 NCBI GeneID    2041
 NCBI Accession #    NP_005223.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005232.4 [Other Products]
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 UniProt Secondary Accession #    Q15405; A1L3V3; B5A966; B5A967 [Other Products]
 UniProt Related Accession #    P21709 [Other Products]
 Molecular Weight    108kDa
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 NCBI Official Full Name    ephrin type-A receptor 1
 NCBI Official Synonym Full Names    EPH receptor A1
 NCBI Official Symbol    EPHA1 [Similar Products]
 NCBI Official Synonym Symbols   
EPH; EPHT; EPHT1
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 1; hEpha1; oncogene EPH; eph tyrosine kinase 1; soluble EPHA1 variant 1; soluble EPHA1 variant 2; tyrosine-protein kinase receptor EPH; erythropoietin-producing hepatoma receptor; erythropoietin-producing hepatoma amplified sequence
 UniProt Protein Name    Ephrin type-A receptor 1
 UniProt Synonym Protein Names   
EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH
 Protein Family    Ephrin type-A receptor
 UniProt Gene Name    EPHA1 [Similar Products]
 UniProt Synonym Gene Names    EPH; EPHT; EPHT1; hEpha1 [Similar Products]
 UniProt Entry Name    EPHA1_HUMAN
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 NCBI Summary for EphA1    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EphA1    EphA1: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Misexpressed in several cancers, including upregulation in head and neck cancer, and downregulation in invasive breast cancer cell lines and glioblastoma

Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; TK group; Eph family

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: transmembrane-ephrin receptor activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: axon guidance; peptidyl-tyrosine phosphorylation; somatic stem cell maintenance; protein amino acid autophosphorylation; positive regulation of angiogenesis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; positive regulation of stress fiber formation; ephrin receptor signaling pathway; negative regulation of protein kinase activity; angiogenesis; positive regulation of cell-matrix adhesion; negative regulation of cell migration; positive regulation of cell migration
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 Research Articles on EphA1    1. Suggest EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EphA1 antibodyPathways associated with anti-EphA1 antibody
 Reference Product  PubMed Publications
 EPHA2 antibody  >36 publications with EphA1 and EPHA2
 SRC antibody  >7 publications with EphA1 and SRC
 EFNA1 antibody  >4 publications with EphA1 and EFNA1
 EFNA3 antibody  >2 publications with EphA1 and EFNA3
 FYN antibody  >1 publications with EphA1 and FYN
 EFNA5 antibody  >1 publications with EphA1 and EFNA5
 NGEF antibody  >1 publications with EphA1 and NGEF
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram
Diseases associated with anti-EphA1 antibodyOrgans/Tissues associated with anti-EphA1 antibody
 Disease Name  Pubmed Publications
 Alzheimer Disease Antibodies  >23 publications with EphA1 and Alzheimer Disease
 Adenocarcinoma Antibodies  >8 publications with EphA1 and Adenocarcinoma
 Inflammation Antibodies  >6 publications with EphA1 and Inflammation
 Colorectal Neoplasms Antibodies  >6 publications with EphA1 and Colorectal Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with EphA1 and Carcinoma, Hepatocellular
 Carcinoma, Squamous Cell Antibodies  >4 publications with EphA1 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >3 publications with EphA1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >3 publications with EphA1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >3 publications with EphA1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >3 publications with EphA1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with EphA1 and Brain
 Blood Antibodies  >21 publications with EphA1 and Blood
 Lung Antibodies  >11 publications with EphA1 and Lung
 Embryonic Tissue Antibodies  >11 publications with EphA1 and Embryonic Tissue
 Lymph Node Antibodies  >7 publications with EphA1 and Lymph Node
 Liver Antibodies  >5 publications with EphA1 and Liver
 Thymus Antibodies  >3 publications with EphA1 and Thymus
 Testis Antibodies  >2 publications with EphA1 and Testis
 Pancreas Antibodies  >2 publications with EphA1 and Pancreas
 Heart Antibodies  >2 publications with EphA1 and Heart
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