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anti-EphA2 antibody :: Mouse anti-Human EphA2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850883
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EphA2, Monoclonal Antibody

 Also Known As   

EphA2 Antibody

 Product Synonym Names    ECK; EPHA2; Entrez Gene:
 Product Gene Name   

anti-EphA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176946
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 Clonality    Monoclonal
 Clone Number    1B3C7
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of EphA2 expressed in E. Coli.
 Species    Mouse IgM
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 Preparation and Storage    Store at 4 degree C. For long term storage, store at -20 degree C
 Other Notes    Small volumes of anti-EphA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EphA2 antibody

   Background: EPH receptor A2 (EphA2), with 976-amino acid protein (about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers.EphA2 may serve as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.
 Product Categories/Family for anti-EphA2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-EphA2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-EphA2 antibody    WB: 1/500 - 1/2000, IHC:1/200 - 1/1000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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 Testing Data of anti-EphA2 antibody    Figure 1. Western blot analysis using EphA2 mouse mAb against NIH/3T3 cell lysate.
anti-EphA2 antibody Testing Data image
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 Testing Data #2 of anti-EphA2 antibody    Figure 2. Immunohistochemical analysis of paraffin-embedded human skin carcinoma (left) and pancreas carcinoma (right) tissue, showing cytoplasmic localization using EphA2 mouse mAb with DAB staining.
anti-EphA2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for EphA2. It may not necessarily be applicable to this product.
 NCBI GI #    32967311
 NCBI GeneID    1969
 NCBI Accession #    NP_004422.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004431.3 [Other Products]
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 UniProt Secondary Accession #    Q8N3Z2; B5A968 [Other Products]
 UniProt Related Accession #    P29317 [Other Products]
 Molecular Weight    54,305 Da
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 NCBI Official Full Name    ephrin type-A receptor 2
 NCBI Official Synonym Full Names    EPH receptor A2
 NCBI Official Symbol    EPHA2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase
 UniProt Protein Name    Ephrin type-A receptor 2
 UniProt Synonym Protein Names   
Epithelial cell kinase; Tyrosine-protein kinase receptor ECK
 Protein Family    Ephrin type-A receptor
 UniProt Gene Name    EPHA2 [Similar Products]
 UniProt Synonym Gene Names    ECK [Similar Products]
 UniProt Entry Name    EPHA2_HUMAN
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 NCBI Summary for EphA2    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
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 UniProt Comments for EphA2    EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC; Protein kinase, TK; TK group; Eph family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; focal adhesion; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: neural tube development; axial mesoderm formation; axon guidance; cell migration; negative regulation of protein kinase B signaling cascade; peptidyl-tyrosine phosphorylation; viral reproduction; multicellular organismal development; notochord formation; mammary gland epithelial cell proliferation; osteoclast differentiation; bone remodeling; regulation of blood vessel endothelial cell migration; regulation of angiogenesis; osteoblast differentiation; keratinocyte differentiation; regulation of cell adhesion mediated by integrin; DNA damage response, signal transduction resulting in induction of apoptosis; notochord cell development; protein kinase B signaling cascade; ephrin receptor signaling pathway; angiogenesis; cell adhesion; vasculogenesis; skeletal development

Disease: Cataract 6, Multiple Types
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 Research Articles on EphA2    1. Data indicate that mutations introduced into the alternative dimerization motifs of the EphA2 receptor tyrosine kinase transmembrane domain induced an opposite effect on receptor activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EphA2 antibodyPathways associated with anti-EphA2 antibody
 Reference Product  PubMed Publications
 EPHA1 antibody  >36 publications with EphA2 and EPHA1
 EFNA1 antibody  >15 publications with EphA2 and EFNA1
 CBL antibody  >11 publications with EphA2 and CBL
 EFNA4 antibody  >4 publications with EphA2 and EFNA4
 INPPL1 antibody  >3 publications with EphA2 and INPPL1
 TP53 antibody  >3 publications with EphA2 and TP53
 GIT1 antibody  >2 publications with EphA2 and GIT1
 TIAM1 antibody  >2 publications with EphA2 and TIAM1
 EFNA5 antibody  >2 publications with EphA2 and EFNA5
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
Diseases associated with anti-EphA2 antibodyOrgans/Tissues associated with anti-EphA2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >61 publications with EphA2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >43 publications with EphA2 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >35 publications with EphA2 and Ovarian Neoplasms
 Disease Progression Antibodies  >35 publications with EphA2 and Disease Progression
 Neoplasms, Experimental Antibodies  >33 publications with EphA2 and Neoplasms, Experimental
 Lung Diseases Antibodies  >30 publications with EphA2 and Lung Diseases
 Nervous System Diseases Antibodies  >27 publications with EphA2 and Nervous System Diseases
 Brain Diseases Antibodies  >26 publications with EphA2 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >25 publications with EphA2 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >20 publications with EphA2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >92 publications with EphA2 and Vascular
 Lung Antibodies  >69 publications with EphA2 and Lung
 Brain Antibodies  >62 publications with EphA2 and Brain
 Prostate Antibodies  >45 publications with EphA2 and Prostate
 Liver Antibodies  >29 publications with EphA2 and Liver
 Eye Antibodies  >29 publications with EphA2 and Eye
 Lymph Node Antibodies  >27 publications with EphA2 and Lymph Node
 Embryonic Tissue Antibodies  >24 publications with EphA2 and Embryonic Tissue
 Skin Antibodies  >18 publications with EphA2 and Skin
 Kidney Antibodies  >15 publications with EphA2 and Kidney
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