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anti-EMR2 antibody :: Hamster anti-Human Epidermal Growth Factor-Like Module-Containing Mucin-Like Receptor 3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608843 anti-EMR2 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Epidermal Growth Factor-Like Module-Containing Mucin-Like Receptor 3 (EMR2), Monoclonal Antibody

 Also Known As   

Epidermal Growth Factor-Like Module-Containing Mucin-Like Receptor 3 (EGF-like Module Containing Mucin-like Hormone Receptor-like 3, EGF-like Module Containing Mucin-like Receptor 3, EMR3) (FITC)

 Product Synonym Names    Anti -Epidermal Growth Factor-Like Module-Containing Mucin-Like Receptor 3 (EGF-like Module Containing Mucin-like Hormone Receptor-like 3, EGF-like Module Containing Mucin-like Receptor 3, EMR3) (FITC)
 Product Gene Name   

anti-EMR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (14843509..14889353, complement). Location: 19p13.1
 OMIM    606100
 3D Structure    ModBase 3D Structure for Q9UHX3
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    10C111
 Host    Hamster
 Species Reactivity    Human
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 Specificity    Recognizes human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3).
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
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 Immunogen    ARHO-EMR3-CD97 (EGF1) transfectants.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
 Other Notes    Small volumes of anti-EMR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-EMR2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-EMR2 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-EMR2 antibody    Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: Neat; 10ul labels 10e6 cells in 100ul
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NCBI/Uniprot data below describe general gene information for EMR2. It may not necessarily be applicable to this product.
 NCBI GI #    108935835
 NCBI GeneID    30817
 NCBI Accession #    Q9UHX3.2 [Other Products]
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 UniProt Primary Accession #    Q9UHX3 [Other Products]
 UniProt Secondary Accession #    Q8NG96; Q9Y4B1; B4DQ96; E7ESD7; E9PBR1; E9PEL6; E9PFQ5; E9PG91 [Other Products]
 UniProt Related Accession #    Q9UHX3 [Other Products]
 Molecular Weight    90,472 Da [Similar Products]
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 NCBI Official Full Name    EGF-like module-containing mucin-like hormone receptor-like 2
 NCBI Official Synonym Full Names    egf-like module containing, mucin-like, hormone receptor-like 2
 NCBI Official Symbol    EMR2 [Similar Products]
 NCBI Official Synonym Symbols   
CD312
[Similar Products]
 NCBI Protein Information    EGF-like module-containing mucin-like hormone receptor-like 2
 UniProt Protein Name    EGF-like module-containing mucin-like hormone receptor-like 2
 UniProt Synonym Protein Names   
EGF-like module receptor 2
 UniProt Gene Name    EMR2 [Similar Products]
 UniProt Entry Name    EMR2_HUMAN
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 NCBI Summary for EMR2    This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
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 UniProt Comments for EMR2    EMR2: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell migration; inflammatory response; cell adhesion
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 Research Articles on EMR2    1. Using the myeloid cell-restricted EMR2 receptor as a paradigm, we exam the mechanistic relevance of the subunit interaction and demonstrate a critical role for autoproteolysis in mediating receptor signaling and cell activation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EMR2 antibodyPathways associated with anti-EMR2 antibody
 Reference Product  PubMed Publications
 CD97 antibody  >21 publications with EMR2 and CD97
 CD55 antibody  >10 publications with EMR2 and CD55
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Organs/Tissues associated with anti-EMR2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with EMR2 and Blood
 Brain Antibodies  >3 publications with EMR2 and Brain
 Kidney Antibodies  >2 publications with EMR2 and Kidney
 Spleen Antibodies  >2 publications with EMR2 and Spleen
 Connective Tissue Antibodies  >1 publications with EMR2 and Connective Tissue
 Lung Antibodies  >1 publications with EMR2 and Lung
 Thyroid Antibodies  >1 publications with EMR2 and Thyroid
 Bone Marrow Antibodies  >1 publications with EMR2 and Bone Marrow
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