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anti-ESR1 antibody :: Mouse Estrogen Receptor, alpha Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439940 anti-ESR1 antibody
Unit / Price
0.5 mL  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Receptor, alpha (ESR1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Estrogen Receptor, alpha (Marker of Estrogen Dependence)

 Product Synonym Names    Estrogen Receptor alpha delta 4*5, 6, 7*/654 isoform; Estrogen Receptor alpha delta 4 +49 isoform; Nuclear receptor subfamily 3 group A member 1
 Product Gene Name   

anti-ESR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P03372
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    ER506
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.
 Form/Format    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
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 Immunogen    Recombinant human Estrogen Receptor alpha protein (aa2-185)
 Cellular Localization    Nucleus
 Hu-chromosome Location    6q25.1
 Positive Control    MCF-7 Cells or Breast Cancers.
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 Preparation and Storage    Antibody with azide - store at 4 to 8 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-ESR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ESR1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-ESR1 antibody    FC/FACS: 5ul per test per one million cells in 0.1ml or 5ul per 100ul of whole blood
IF: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for ESR1. It may not necessarily be applicable to this product.
 NCBI GI #    62821794
 NCBI GeneID    2099
 NCBI Accession #    NP_000116.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000125.3 [Other Products]
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 UniProt Primary Accession #    P03372 [Other Products]
 UniProt Secondary Accession #    Q13511; Q14276; Q5T5H7; Q6MZQ9; Q9NU51; Q9UDZ7; Q9UIS7 [Other Products]
 UniProt Related Accession #    P03372 [Other Products]
 Molecular Weight    ~67kDa
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 NCBI Official Full Name    estrogen receptor isoform 1
 NCBI Official Synonym Full Names    estrogen receptor 1
 NCBI Official Symbol    ESR1 [Similar Products]
 NCBI Official Synonym Symbols   
ER; ESR; Era; ESRA; ESTRR; NR3A1
[Similar Products]
 NCBI Protein Information    estrogen receptor
 UniProt Protein Name    Estrogen receptor
 UniProt Synonym Protein Names   
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
 Protein Family    Estrogen receptor
 UniProt Gene Name    ESR1 [Similar Products]
 UniProt Synonym Gene Names    ESR; NR3A1; ER [Similar Products]
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 NCBI Summary for ESR1    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
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 UniProt Comments for ESR1    Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
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Product References and Citations for anti-ESR1 antibody

   Zafrani B, et. al. Histopathology 2000; 37(6), 536545. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 14741481.
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 Research Articles on ESR1    1. These results indicate an interaction between Brf1 and ER alpha, which synergistically regulates the transcription of Pol III genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ESR1 antibodyPathways associated with anti-ESR1 antibody
 Reference Product  PubMed Publications
 ESR2 antibody  >235 publications with ESR1 and ESR2
 JUN antibody  >100 publications with ESR1 and JUN
 PGR antibody  >89 publications with ESR1 and PGR
 ERBB2 antibody  >45 publications with ESR1 and ERBB2
 BRCA1 antibody  >27 publications with ESR1 and BRCA1
 MYC antibody  >25 publications with ESR1 and MYC
 EGFR antibody  >20 publications with ESR1 and EGFR
 CCND1 antibody  >19 publications with ESR1 and CCND1
 TP53 antibody  >14 publications with ESR1 and TP53
 SP1 antibody  >11 publications with ESR1 and SP1
 Products by Pathway  Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-ESR1 antibodyOrgans/Tissues associated with anti-ESR1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >349 publications with ESR1 and Neoplasms
 Breast Neoplasms Antibodies  >220 publications with ESR1 and Breast Neoplasms
 Female Urogenital Diseases Antibodies  >87 publications with ESR1 and Female Urogenital Diseases
 Carcinoma Antibodies  >85 publications with ESR1 and Carcinoma
 Adenocarcinoma Antibodies  >43 publications with ESR1 and Adenocarcinoma
 Disease Progression Antibodies  >38 publications with ESR1 and Disease Progression
 Bone Diseases, Metabolic Antibodies  >35 publications with ESR1 and Bone Diseases, Metabolic
 Obesity Antibodies  >32 publications with ESR1 and Obesity
 Coronary Artery Disease Antibodies  >23 publications with ESR1 and Coronary Artery Disease
 Prostatic Neoplasms Antibodies  >22 publications with ESR1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with ESR1 and Brain
 Uterus Antibodies  >60 publications with ESR1 and Uterus
 Ovary Antibodies  >52 publications with ESR1 and Ovary
 Heart Antibodies  >41 publications with ESR1 and Heart
 Testis Antibodies  >38 publications with ESR1 and Testis
 Prostate Antibodies  >33 publications with ESR1 and Prostate
 Muscle Antibodies  >28 publications with ESR1 and Muscle
 Connective Tissue Antibodies  >26 publications with ESR1 and Connective Tissue
 Lung Antibodies  >25 publications with ESR1 and Lung
 Lymph Node Antibodies  >17 publications with ESR1 and Lymph Node
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