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anti-Esr2 antibody :: Mouse Estrogen Receptor beta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190148 anti-Esr2 antibody
Unit / Price
0.1 mL  /  $410 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Receptor beta (Esr2), Monoclonal Antibody

 Also Known As   

Estrogen Receptor- beta Monoclonal Antibody

 Product Synonym Names    Anti-Estrogen Receptor beta; Estrogen Receptor-beta
 Product Gene Name   

anti-Esr2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_005105.2 (98691167..98775299, complement). Location: 6q24
 3D Structure    ModBase 3D Structure for Q59IV8
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 Clonality    Monoclonal
 Isotype    IgG2b kappa
 Host    Mouse
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 Specificity    Anti-Estrogen Receptor beta [Murine MAb to fusion protein corresponding to aa 1-153 of human estrogen receptor-beta, a member of the steroid family of nuclear receptors.]
This antibody recognizes human ER- beta , a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER- beta are very similar to ER- alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER- alpha , ER- beta binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements
 Form/Format    100 ug Protein G-purified antibody in PBS, pH 7.4
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 Antigen    6-His fusion protein containing the region encoding aa 1-153of human estrogen receptor- beta (ER- beta ) expressed in E. coli.
 Stabilizer    None
 Preservatives    None. Available on request.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
 Other Notes    Small volumes of anti-Esr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Esr2 antibody    Cancer Research Products
 Applications Tested/Suitable for anti-Esr2 antibody   


 Application Notes for anti-Esr2 antibody    Immunoblotting: use at 1-5 ug/ml.
Positive controls: Native receptor from human thymus, spleen, ovary, and testisor recombinant protein.
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NCBI/Uniprot data below describe general gene information for Esr2. It may not necessarily be applicable to this product.
 NCBI GI #    6978817
 NCBI GeneID    25149
 NCBI Accession #    NP_036886.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012754.1 [Other Products]
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 UniProt Primary Accession #    Q59IV8 [Other Products]
 UniProt Related Accession #    Q59IV8; Q59IV9; Q62986 [Other Products]
 Molecular Weight    63,322 Da [Similar Products]
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 NCBI Official Full Name    estrogen receptor beta
 NCBI Official Synonym Full Names    estrogen receptor 2 (ER beta)
 NCBI Official Symbol    Esr2 [Similar Products]
 NCBI Official Synonym Symbols   
Erb2; ERbeta; ER-beta
[Similar Products]
 NCBI Protein Information    estrogen receptor beta; estrogen receptor 2 beta; nuclear receptor subfamily 3 group A member 2
 UniProt Protein Name    Estrogen receptor 2 beta, isoform CRA_a
 Protein Family    Estrogen receptor
 UniProt Gene Name    Esr2 [Similar Products]
 UniProt Synonym Gene Names    ERb2 [Similar Products]
 UniProt Entry Name    Q59IV8_RAT
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 NCBI Summary for Esr2    binds estrogen and mediates transcriptional activation [RGD]
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 UniProt Comments for Esr2    ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: neuron projection; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium

Molecular Function: ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; estrogen receptor activity; hormone binding; zinc ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity

Biological Process: prostate gland development; hypothalamus development; behavioral fear response; estrogen receptor signaling pathway; induction of apoptosis by hormones; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; amygdala development; negative regulation of transcription from RNA polymerase II promoter; response to insecticide; uterus development; response to organic cyclic substance; response to estradiol stimulus; negative regulation of cell proliferation; learning and/or memory; ovarian follicle development; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; cerebellum development; female gonad development; negative regulation of epithelial cell proliferation; response to nutrient levels; steroid hormone receptor signaling pathway; response to drug; transcription, DNA-dependent; male gonad development; vagina development; Sertoli cell proliferation; response to testosterone stimulus; Sertoli cell development; regulation of cell proliferation; response to genistein; response to ethanol; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of transcription factor activity; brain development; response to activity; negative regulation of behavior; response to water deprivation
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 Research Articles on Esr2    1. Beta estrogen receptor agonists inhibited hemorrhagic-shock-induced hyperpermeability. 17beta-estradiol protection may be mediated in part by beta estrogen receptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Esr2 antibodyDiseases associated with anti-Esr2 antibody
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >55 publications with Esr2 and Neoplasms
 Cardiovascular Diseases Antibodies  >24 publications with Esr2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >23 publications with Esr2 and Breast Neoplasms
 Nervous System Diseases Antibodies  >17 publications with Esr2 and Nervous System Diseases
 Gonadal Disorders Antibodies  >15 publications with Esr2 and Gonadal Disorders
 Heart Diseases Antibodies  >10 publications with Esr2 and Heart Diseases
 Hypertension Antibodies  >10 publications with Esr2 and Hypertension
 Endometriosis Antibodies  >9 publications with Esr2 and Endometriosis
 Osteoporosis, Postmenopausal Antibodies  >9 publications with Esr2 and Osteoporosis, Postmenopausal
 Carcinoma Antibodies  >8 publications with Esr2 and Carcinoma
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