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anti-FAS antibody :: Mouse FAS Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140095 anti-FAS antibody
Unit / Price
0.5 mg  /  $230 +1 FREE 8GB USB
1 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FAS, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti Human FAS (CD95) Blocking

 Product Synonym Names    FAS Antibody; FAS Blocking Antibody (CD95), Mouse anti Human; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95; Tumor necrosis factor receptor superfamily member 6 TNR6; APT1; FAS1; TNFRSF6
 Product Gene Name   

anti-FAS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600212
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    NYRhFAS
 Host    Mouse
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 Purity/Purification    Ion exchange column Protein concentration1 mg/ml in PBS (after reconstitution).
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 Additional Information    This is a BLOCKING antibody and will block FAS-mediated apoptosis.
 Reconstitution    Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    Recombinant Human FAS.
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 Preparation and Storage    In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Antibody is shipped lyophilized at ambient temperature.
 Other Notes    Small volumes of anti-FAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FAS antibody

   Introduction: The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligimerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure and another caspase substrate is DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of fas-mediated apoptosis using similar mechanisms.
 Product Categories/Family for anti-FAS antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-FAS antibody   

ELISA (EIA)

 Application Notes for anti-FAS antibody    By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.
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NCBI/Uniprot data below describe general gene information for FAS. It may not necessarily be applicable to this product.
 NCBI GI #    41872631
 NCBI GeneID    2194
 NCBI Accession #    NP_004095.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_004104.4 [Other Products]
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 UniProt Secondary Accession #    Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0 [Other Products]
 UniProt Related Accession #    P49327 [Other Products]
 Molecular Weight    273,427 Da
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 NCBI Official Full Name    fatty acid synthase
 NCBI Official Synonym Full Names    fatty acid synthase
 NCBI Official Symbol    FASN [Similar Products]
 NCBI Official Synonym Symbols   
FAS; OA-519; SDR27X1
[Similar Products]
 NCBI Protein Information    fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1
 UniProt Protein Name    Fatty acid synthase
 Protein Family    Fascin
 UniProt Gene Name    FASN [Similar Products]
 UniProt Synonym Gene Names    FAS [Similar Products]
 UniProt Entry Name    FAS_HUMAN
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 NCBI Summary for FAS    The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FAS    FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Protein type: EC 2.3.1.85; EC 4.2.1.59; Acetyltransferase; EC 1.1.1.100; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 3.1.2.14; Lyase; EC 1.3.1.39; Oxidoreductase; Hydrolase; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: Golgi apparatus; glycogen granule; membrane; mitochondrion; cytoplasm; plasma membrane; melanosome; cytosol

Molecular Function: protein homodimerization activity; fatty-acid synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; drug binding; [acyl-carrier-protein] S-acetyltransferase activity; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity

Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process
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 Research Articles on FAS    1. Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FAS antibodyDiseases associated with anti-FAS antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >145 publications with FAS and Fatty Liver
 Obesity Antibodies  >108 publications with FAS and Obesity
 Liver Diseases Antibodies  >66 publications with FAS and Liver Diseases
 Breast Neoplasms Antibodies  >52 publications with FAS and Breast Neoplasms
 Insulin Resistance Antibodies  >49 publications with FAS and Insulin Resistance
 Inflammation Antibodies  >40 publications with FAS and Inflammation
 Disease Models, Animal Antibodies  >26 publications with FAS and Disease Models, Animal
 Weight Loss Antibodies  >22 publications with FAS and Weight Loss
 Necrosis Antibodies  >19 publications with FAS and Necrosis
 Weight Gain Antibodies  >19 publications with FAS and Weight Gain
Organs/Tissues associated with anti-FAS antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >169 publications with FAS and Liver
 Adipose Tissue Antibodies  >120 publications with FAS and Adipose Tissue
 Blood Antibodies  >105 publications with FAS and Blood
 Connective Tissue Antibodies  >74 publications with FAS and Connective Tissue
 Muscle Antibodies  >54 publications with FAS and Muscle
 Prostate Antibodies  >49 publications with FAS and Prostate
 Mammary Gland Antibodies  >35 publications with FAS and Mammary Gland
 Lung Antibodies  >23 publications with FAS and Lung
 Brain Antibodies  >18 publications with FAS and Brain
 Kidney Antibodies  >18 publications with FAS and Kidney
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