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anti-FER antibody :: Mouse anti-Human FER Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120259
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FER, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human FER

 Product Synonym Names    Homo sapiens fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) (FER); TYK3
 Product Gene Name   

anti-FER antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176942
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2358C3a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-FER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FER antibody

   Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-FER antibody   

Dot Blot (DB), Immunoprecipitation (IP), Western Blot (WB)

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 Quality Control of anti-FER antibody    Western blot analysis of immunized recombinant protein, using anti-FER monoclonal antibody.
anti-FER antibody Quality Control image
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 Quality Control #2 of anti-FER antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-FER antibody Quality Control #2 image
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 Western Blot (WB) of anti-FER antibody    Detection of FER by Western blot.

Samples: Whole cell lysate from human HeLa (H, 25 ug) and mouse NIH3T3 (M, 25 ug) cells. [Lot No. 2358C3a-1]

Predicted molecular weight: 94 kDa
anti-FER antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-FER antibody    Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-FER mAb. [Lot No. 2358C3a-1]

Predicted molecular weight: 94 kDa
anti-FER antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for FER. It may not necessarily be applicable to this product.
 NCBI GI #    119964720
 NCBI GeneID    2241
 NCBI Accession #    NP_005237.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005246 [Other Products]
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 UniProt Secondary Accession #    B2RCR4; B4DSQ2; H2FLB8 [Other Products]
 UniProt Related Accession #    P16591 [Other Products]
 Molecular Weight    51,643 Da
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 NCBI Official Full Name    Homo sapiens fer (fps/fes related) tyrosine kinase (FER), mRNA
 NCBI Official Synonym Full Names    fer (fps/fes related) tyrosine kinase
 NCBI Official Symbol    FER [Similar Products]
 NCBI Official Synonym Symbols   
FerT; TYK3; Pe1Fe3; Pe1Fe6; PPP1R74; Pe1Fe10; Pe1Fe13
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fer; feline encephalitis virus-related kinase FER; fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-Fer; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; proto-oncogene c-Fer; truncated fer (fps/fes related) tyrosine kinase; tyrosine kinase 3
 UniProt Protein Name    Tyrosine-protein kinase Fer
 UniProt Synonym Protein Names   
Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer
 Protein Family    Ferritin
 UniProt Gene Name    FER [Similar Products]
 UniProt Entry Name    FER_HUMAN
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 NCBI Summary for FER    Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FER    Fer: a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; TK group; Fer family

Chromosomal Location of Human Ortholog: 5q21

Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; cytoplasm; nuclear chromatin; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton

Molecular Function: protein binding; cadherin binding; protein-tyrosine kinase activity; gamma-catenin binding; non-membrane spanning protein tyrosine kinase activity; actin binding; protein kinase binding; lipid binding; protein phosphatase 1 binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding

Biological Process: regulation of mast cell degranulation; peptidyl-tyrosine phosphorylation; diapedesis; protein amino acid autophosphorylation; tyrosine phosphorylation of Stat3 protein; negative regulation of mast cell activation during immune response; platelet-derived growth factor receptor signaling pathway; response to lipopolysaccharide; chemotaxis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of cell proliferation; cell adhesion; cell differentiation; regulation of protein amino acid phosphorylation; cytokine and chemokine mediated signaling pathway; microtubule cytoskeleton organization and biogenesis; regulation of epidermal growth factor receptor signaling pathway; regulation of cell proliferation; cell proliferation; cellular response to insulin stimulus; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; innate immune response; mitotic cell cycle; positive regulation of cell migration
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 Research Articles on FER    1. Fer contributes to aberrant androgen receptor signaling via pSTAT3 cross-talk during castrate-resistant prostate cancer progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FER antibodyPathways associated with anti-FER antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >23 publications with FER and CTNNB1
 STAT3 antibody  >15 publications with FER and STAT3
 KITLG antibody  >6 publications with FER and KITLG
 CTTN antibody  >4 publications with FER and CTTN
 PTPN11 antibody  >3 publications with FER and PTPN11
 CDH2 antibody  >1 publications with FER and CDH2
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By SCF-KIT Pathway antibodies  Signaling By SCF-KIT Pathway Diagram
 Signaling Events Mediated By PTP1B Pathway antibodies  Signaling Events Mediated By PTP1B Pathway Diagram
 Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway antibodies  Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway Diagram
Diseases associated with anti-FER antibodyOrgans/Tissues associated with anti-FER antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >46 publications with FER and Carcinoma
 Heart Diseases Antibodies  >42 publications with FER and Heart Diseases
 Brain Diseases Antibodies  >39 publications with FER and Brain Diseases
 Inflammation Antibodies  >31 publications with FER and Inflammation
 Weight Gain Antibodies  >30 publications with FER and Weight Gain
 Hypertension Antibodies  >23 publications with FER and Hypertension
 Kidney Diseases Antibodies  >22 publications with FER and Kidney Diseases
 Liver Diseases Antibodies  >16 publications with FER and Liver Diseases
 Necrosis Antibodies  >16 publications with FER and Necrosis
 Edema Antibodies  >12 publications with FER and Edema
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >127 publications with FER and Brain
 Muscle Antibodies  >60 publications with FER and Muscle
 Liver Antibodies  >50 publications with FER and Liver
 Kidney Antibodies  >46 publications with FER and Kidney
 Lung Antibodies  >45 publications with FER and Lung
 Skin Antibodies  >24 publications with FER and Skin
 Mixed Antibodies  >18 publications with FER and Mixed
 Testis Antibodies  >17 publications with FER and Testis
 Embryonic Tissue Antibodies  >17 publications with FER and Embryonic Tissue
 Connective Tissue Antibodies  >12 publications with FER and Connective Tissue
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