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anti-FERMT2 antibody :: Mouse anti-Human FERMT2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS830915
Western Blot (WB)
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FERMT2, Monoclonal Antibody

 Also Known As   

FERMT2 antibody

 Product Synonym Names    Monoclonal FERMT2; Anti-FERMT2; Fermitin family member 2; KIND2; MIG2; PLEKHC1; UNC112B; Kindlin 2; MIG-2; MIG 2; FERMT2; FERMT 2; FERMT-2
 Product Gene Name   

anti-FERMT2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607746
 3D Structure    ModBase 3D Structure for Q96AC1
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    22 E7
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    FERMT2 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    FERMT2 participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. FERMT2 also recruits migfilin (FBLP1) protein to cell-ECM focaladhesion sites.
 Immunogen    FERMT2 antibody was raised in mouse using a full length recombinant protein of human FERMT2 (NP_006823) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-FERMT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FERMT2 antibody

   Mouse monoclonal FERMT2 antibody
 Product Categories/Family for anti-FERMT2 antibody    Cell Biology
 Applications Tested/Suitable for anti-FERMT2 antibody   

Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-FERMT2 antibody    IF: 1:100
WB: 1:500
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 Western Blot (WB) of anti-FERMT2 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant FERMT2 protein (Right) or empty vector (Left) detected with FERMT2 antibody
anti-FERMT2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FERMT2. It may not necessarily be applicable to this product.
 NCBI GI #    29789006
 NCBI GeneID    10979
 NCBI Accession #    NP_006823 [Other Products]
 NCBI GenBank Nucleotide #    NM_006832.2 [Other Products]
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 UniProt Primary Accession #    Q96AC1 [Other Products]
 UniProt Secondary Accession #    Q14840; Q86TY7; B5TJY2 [Other Products]
 UniProt Related Accession #    Q96AC1 [Other Products]
 Molecular Weight    78,675 Da
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 NCBI Official Full Name    fermitin family homolog 2 isoform 1
 NCBI Official Synonym Full Names    fermitin family member 2
 NCBI Official Symbol    FERMT2 [Similar Products]
 NCBI Official Synonym Symbols   
MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B
[Similar Products]
 NCBI Protein Information    fermitin family homolog 2
 UniProt Protein Name    Fermitin family homolog 2
 UniProt Synonym Protein Names   
Kindlin-2; Mitogen-inducible gene 2 protein; MIG-2; Pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1
 Protein Family    Fermitin family
 UniProt Gene Name    FERMT2 [Similar Products]
 UniProt Synonym Gene Names    KIND2; MIG2; PLEKHC1; MIG-2; PH domain-containing family C member 1 [Similar Products]
 UniProt Entry Name    FERM2_HUMAN
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 UniProt Comments for FERMT2    Kindlin-2: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. Belongs to the kindlin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: nucleoplasm; filamentous actin; I band; extrinsic to internal side of plasma membrane; cell surface; focal adhesion; cytoplasm; stress fiber; cell cortex; cytosol; nucleus

Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding

Biological Process: integrin activation; integrin-mediated signaling pathway; focal adhesion formation; regulation of cell shape; Wnt receptor signaling pathway; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion
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 Research Articles on FERMT2    1. Data indicate that Kindlin-2 mRNA levels in adult is highly expressed in mesoderm-derived organs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FERMT2 antibodyPathways associated with anti-FERMT2 antibody
 Reference Product  PubMed Publications
 ILK antibody  >1 publications with FERMT2 and ILK
 Products by Pathway  Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram
Diseases associated with anti-FERMT2 antibodyOrgans/Tissues associated with anti-FERMT2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with FERMT2 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with FERMT2 and Neoplasm Metastasis
 Weight Loss Antibodies  >1 publications with FERMT2 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with FERMT2 and Muscle
 Heart Antibodies  >1 publications with FERMT2 and Heart
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