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anti-FST antibody :: Mouse FOLLISTATIN 288 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219673 anti-FST antibody
Unit / Price
0.1 mg  /  $755 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOLLISTATIN 288 (FST), Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN FOLLISTATIN 288

 Product Gene Name   

anti-FST antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    136470
 3D Structure    ModBase 3D Structure for P19883
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    17/2
 Host    Mouse
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 Specificity    This item recognises human follistatin isoform 288 (FS288).

Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin.

As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair.

Clone 17/2 has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Recombinant human FS288
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-FST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FST antibody

   MBS219673 recognises human follistatin isoform 288 (FS288). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin. As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair. Clone 17/2 has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.
 Applications Tested/Suitable for anti-FST antibody   

ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-FST antibody    Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
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NCBI/Uniprot data below describe general gene information for FST. It may not necessarily be applicable to this product.
 NCBI GI #    5453652
 NCBI GeneID    10468
 NCBI Accession #    NP_006341.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006350.3 [Other Products]
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 UniProt Primary Accession #    P19883 [Other Products]
 UniProt Secondary Accession #    Q9BTH0; B5BU94 [Other Products]
 UniProt Related Accession #    P19883 [Other Products]
 Molecular Weight    34,803 Da [Similar Products]
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 NCBI Official Full Name    follistatin isoform FST317
 NCBI Official Synonym Full Names    follistatin
 NCBI Official Symbol    FST [Similar Products]
 NCBI Official Synonym Symbols   
FS
[Similar Products]
 NCBI Protein Information    follistatin; activin-binding protein; follistatin isoform FST317
 UniProt Protein Name    Follistatin
 UniProt Synonym Protein Names   
Activin-binding protein
 Protein Family    Follistatin
 UniProt Gene Name    FST [Similar Products]
 UniProt Synonym Gene Names    FS [Similar Products]
 UniProt Entry Name    FST_HUMAN
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 NCBI Summary for FST    Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FST    FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: positive regulation of hair follicle development; BMP signaling pathway; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth

Disease: Polycystic Ovary Syndrome 1
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 Research Articles on FST    1. an imbalance between activin-A and follistatin contributes to the pathogenesis of cigarette smoke-induced inflammation and COPD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FST antibodyPathways associated with anti-FST antibody
 Reference Product  PubMed Publications
 MSTN antibody  >16 publications with FST and MSTN
 INHBA antibody  >11 publications with FST and INHBA
 BMP2 antibody  >6 publications with FST and BMP2
 BMPR2 antibody  >5 publications with FST and BMPR2
 BMP4 antibody  >4 publications with FST and BMP4
 BMP7 antibody  >3 publications with FST and BMP7
 Products by Pathway  Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-FST antibodyOrgans/Tissues associated with anti-FST antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >385 publications with FST and Disease Models, Animal
 Learning Disorders Antibodies  >53 publications with FST and Learning Disorders
 Inflammation Antibodies  >47 publications with FST and Inflammation
 Cardiovascular Diseases Antibodies  >38 publications with FST and Cardiovascular Diseases
 Necrosis Antibodies  >36 publications with FST and Necrosis
 Cognition Disorders Antibodies  >26 publications with FST and Cognition Disorders
 Weight Loss Antibodies  >19 publications with FST and Weight Loss
 Breast Neoplasms Antibodies  >14 publications with FST and Breast Neoplasms
 Hypertension Antibodies  >12 publications with FST and Hypertension
 Abnormalities, Drug-Induced Antibodies  >11 publications with FST and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >823 publications with FST and Brain
 Nerve Antibodies  >78 publications with FST and Nerve
 Skin Antibodies  >71 publications with FST and Skin
 Bone Antibodies  >53 publications with FST and Bone
 Eye Antibodies  >46 publications with FST and Eye
 Ovary Antibodies  >41 publications with FST and Ovary
 Liver Antibodies  >37 publications with FST and Liver
 Heart Antibodies  >30 publications with FST and Heart
 Adrenal Gland Antibodies  >24 publications with FST and Adrenal Gland
 Testis Antibodies  >18 publications with FST and Testis
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