NP_006341.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
follistatin isoform FST317
NCBI Official Synonym Full Names
follistatin
NCBI Official Synonym Symbols
NCBI Protein Information
follistatin; activin-binding protein; follistatin isoform FST317
UniProt Protein Name
Follistatin
UniProt Synonym Protein Names
Activin-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
FST_HUMAN
NCBI Summary for FST
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
UniProt Comments for FST
FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cytoplasm; extracellular region; nucleus
Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding
Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth
Disease: Polycystic Ovary Syndrome 1
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Products associated with anti-FST antibody
Pathways associated with anti-FST antibody
Diseases associated with anti-FST antibody
Organs/Tissues associated with anti-FST antibody
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