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anti-FYN antibody :: Mouse anti-Human FYN Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850994
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FYN, Monoclonal Antibody

 Also Known As   

FYN Antibody

 Product Synonym Names    SLK; SYN; MGC45350
 Product Gene Name   

anti-FYN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137025
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 Clonality    Monoclonal
 Clone Number    2A10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human FYN expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-FYN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FYN antibody

   Background: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
 Product Categories/Family for anti-FYN antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-FYN antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-FYN antibody    WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-FYN antibody    Figure 1: Western blot analysis using FYN mouse mAb against Hela cell lysate.
anti-FYN antibody Testing Data image
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 Testing Data #2 of anti-FYN antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and brain tissues (right) using FYN mouse mAb with DAB staining.
anti-FYN antibody Testing Data #2 image
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 Testing Data #3 of anti-FYN antibody    anti-FYN antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for FYN. It may not necessarily be applicable to this product.
 NCBI GI #    4503823
 NCBI GeneID    2534
 NCBI Accession #    NP_002028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002037.5 [Other Products]
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 UniProt Secondary Accession #    Q16248; Q5R3A6; Q5R3A7; Q8N5D7; B5BU57; E1P557; H0UI48 [Other Products]
 UniProt Related Accession #    P06241 [Other Products]
 Molecular Weight    61kDa
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 NCBI Official Full Name    tyrosine-protein kinase Fyn isoform a
 NCBI Official Synonym Full Names    FYN proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    FYN [Similar Products]
 NCBI Official Synonym Symbols   
SLK; SYN; p59-FYN
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fyn; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator
 UniProt Protein Name    Tyrosine-protein kinase Fyn
 UniProt Synonym Protein Names   
Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
 Protein Family    FYN-binding protein
 UniProt Gene Name    FYN [Similar Products]
 UniProt Synonym Gene Names    SLK [Similar Products]
 UniProt Entry Name    FYN_HUMAN
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 NCBI Summary for FYN    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FYN    Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy.

Protein type: Oncoprotein; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: extrinsic to internal side of plasma membrane; mitochondrion; postsynaptic density; plasma membrane; actin filament; cytosol; nucleus; endosome; lipid raft

Molecular Function: tubulin binding; CD8 receptor binding; protein binding; ephrin receptor binding; G-protein-coupled receptor binding; peptide hormone receptor binding; protein-tyrosine kinase activity; metal ion binding; T cell receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoinositide 3-kinase binding; glycoprotein binding; CD4 receptor binding; ATP binding

Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; viral reproduction; T cell activation; neuron migration; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell shape; calcium ion transport; forebrain development; ephrin receptor signaling pathway; feeding behavior; negative regulation of neuron apoptosis; cell differentiation; response to drug; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; dendrite morphogenesis; activated T cell proliferation; learning; regulation of defense response to virus by virus; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; detection of mechanical stimulus involved in sensory perception of pain; response to ethanol; T cell costimulation; innate immune response; negative regulation of protein catabolic process; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on FYN    1. Fyn expression in mdMSCs contributes to basal cytoskeletal architecture and, when associated with FAs, functions as a proximal mechanical effector for environmental signals that influence MSC lineage allocation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FYN antibodyPathways associated with anti-FYN antibody
 Reference Product  PubMed Publications
 CBL antibody  >66 publications with FYN and CBL
 FYB antibody  >46 publications with FYN and FYB
 SH2D1A antibody  >39 publications with FYN and SH2D1A
 BCAR1 antibody  >13 publications with FYN and BCAR1
 KHDRBS1 antibody  >12 publications with FYN and KHDRBS1
 GRIN2B antibody  >1 publications with FYN and GRIN2B
 GP6 antibody  >1 publications with FYN and GP6
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-FYN antibodyOrgans/Tissues associated with anti-FYN antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >174 publications with FYN and Nervous System Diseases
 Brain Diseases Antibodies  >123 publications with FYN and Brain Diseases
 Inflammation Antibodies  >79 publications with FYN and Inflammation
 Cell Transformation, Neoplastic Antibodies  >49 publications with FYN and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >46 publications with FYN and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >45 publications with FYN and Neoplasms, Experimental
 Necrosis Antibodies  >42 publications with FYN and Necrosis
 Lung Diseases Antibodies  >30 publications with FYN and Lung Diseases
 Kidney Diseases Antibodies  >28 publications with FYN and Kidney Diseases
 Heart Diseases Antibodies  >20 publications with FYN and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >782 publications with FYN and Blood
 Brain Antibodies  >452 publications with FYN and Brain
 Nerve Antibodies  >209 publications with FYN and Nerve
 Vascular Antibodies  >107 publications with FYN and Vascular
 Muscle Antibodies  >92 publications with FYN and Muscle
 Bone Antibodies  >91 publications with FYN and Bone
 Kidney Antibodies  >81 publications with FYN and Kidney
 Thymus Antibodies  >75 publications with FYN and Thymus
 Lung Antibodies  >62 publications with FYN and Lung
 Spleen Antibodies  >52 publications with FYN and Spleen
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