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anti-CFH antibody :: Mouse anti-Human Factor H Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS520287 anti-CFH antibody
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor H (CFH), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Human Factor H (Biotin) (Clone: OX-24) (mouse IgG1)

 Product Synonym Names    Factor H (Biotin) (Clone: OX-24) (mouse IgG1); Biotin Anti-Human Factor H Monoclonal Antibody
 Product Gene Name   

anti-CFH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (196621008..196716634). Location: 1q32
 OMIM    126700
 3D Structure    ModBase 3D Structure for P08603
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 Clonality    Monoclonal
 Isotype    Mouse IgG1
 Clone Number    OX-24
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Factor H (Human Factor H)
 Form/Format    Biotin
 Concentration    Antibody Concentration: 0.1 mg/ml (lot specific)
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 Immunogen    Human complement Factor H
 Donor    BALB/c mouse spleen cells
 Fusion Partner    NS-O myeloma
 Presentation    100 ug Biotin conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
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 Preparation and Storage    Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CFH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CFH antibody

   anti-human factor H (beta 1H) (139 kD) monoclonal antibody clone OX-24 inhibits the binding of factor H to surface bound C3. This antibody recognizes the human serum complement protein factor H and a 43- 49kD truncated form of factor H present at low levels (1-5ug/ml) in plasma and urine. Factor H occurs on the surface of some myeloid cell lines. This antibody cross-reacts with sera from other primates (rhesus monkey, cynomolgus monkey, African green monkey) in immunoprecipitation assay, but not with cow, pig, sheep, chick or rabbit sera3. Reported applications of this antibody include flow cytometry, ELISA, immunoprecipitation and Western Blotting.
 Applications Tested/Suitable for anti-CFH antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for CFH. It may not necessarily be applicable to this product.
 NCBI GI #    31965
 NCBI GeneID    3075
 NCBI Accession #    CAA68704.1 [Other Products]
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 UniProt Primary Accession #    P08603 [Other Products]
 UniProt Secondary Accession #    P78435; Q14570; Q2TAZ5; Q38G77; Q5TFM3; Q8N708; Q9NU86; A5PL14 [Other Products]
 UniProt Related Accession #    P08603 [Other Products]
 Molecular Weight    139,096 Da [Similar Products]
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 NCBI Official Full Name    factor H
 NCBI Official Synonym Full Names    complement factor H
 NCBI Official Symbol    CFH [Similar Products]
 NCBI Official Synonym Symbols   
FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3
[Similar Products]
 NCBI Protein Information    complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1
 UniProt Protein Name    Complement factor H
 UniProt Synonym Protein Names   
H factor 1
 Protein Family    Complement factor
 UniProt Gene Name    CFH [Similar Products]
 UniProt Synonym Gene Names    HF; HF1; HF2 [Similar Products]
 UniProt Entry Name    CFAH_HUMAN
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 NCBI Summary for CFH    This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
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 UniProt Comments for CFH    Function: Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Involvement in disease: Basal laminar drusen (BLD) [MIM:126700]: Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.Note: The gene represented in this entry is involved in disease pathogenesis.Complement factor H deficiency (CFHD) [MIM:609814]: A disorder that can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. Laboratory features usually include decreased serum levels of factor H, complement component C3, and a decrease in other terminal complement components, indicating activation of the alternative complement pathway. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18 Ref.22 Ref.23 Ref.24 Ref.25 Ref.27 Ref.30 Ref.36Hemolytic uremic syndrome atypical 1 (AHUS1) [MIM:235400]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Ref.19 Ref.20 Ref.21 Ref.26 Ref.28 Ref.29 Ref.30 Ref.38Age-related macular degeneration 4 (ARMD4) [MIM:610698]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.40

Sequence similarities: Contains 20 Sushi (CCP/SCR) domains.

Sequence caution: The sequence CAB41739.1 differs from that shown. Reason: Frameshift at position 341.
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 Research Articles on CFH    1. a common rs1061170 polymorphism is associated with choroidal blood flow dysregulation in healthy young subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CFH antibodyDiseases associated with anti-CFH antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >417 publications with CFH and Macular Degeneration
 Macular Degeneration, Age-Related, 4 Antibodies  >167 publications with CFH and Macular Degeneration, Age-Related, 4
 Kidney Diseases Antibodies  >134 publications with CFH and Kidney Diseases
 Atypical hemolytic uremic syndrome Antibodies  >90 publications with CFH and Atypical hemolytic uremic syndrome
 Inflammation Antibodies  >72 publications with CFH and Inflammation
 Cardiovascular Diseases Antibodies  >59 publications with CFH and Cardiovascular Diseases
 Atrophy Antibodies  >47 publications with CFH and Atrophy
 Glomerulonephritis, Membranoproliferative Antibodies  >36 publications with CFH and Glomerulonephritis, Membranoproliferative
 Hypertension Antibodies  >26 publications with CFH and Hypertension
 Mental Disorders Antibodies  >24 publications with CFH and Mental Disorders
Organs/Tissues associated with anti-CFH antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >213 publications with CFH and Eye
 Kidney Antibodies  >102 publications with CFH and Kidney
 Vascular Antibodies  >72 publications with CFH and Vascular
 Ear Antibodies  >37 publications with CFH and Ear
 Brain Antibodies  >32 publications with CFH and Brain
 Liver Antibodies  >28 publications with CFH and Liver
 Heart Antibodies  >25 publications with CFH and Heart
 Nerve Antibodies  >13 publications with CFH and Nerve
 Skin Antibodies  >11 publications with CFH and Skin
 Bone Antibodies  >8 publications with CFH and Bone
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