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anti-F7 antibody :: Mouse Factor VII Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530593 anti-F7 antibody
Unit / Price
0.5 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor VII (F7), Monoclonal Antibody

★Popular Item★
 Also Known As   

Factor VII antibody

 Product Synonym Names    Monoclonal Factor VII; Anti-Factor VII; Complement Factor VII
 Product Gene Name   

anti-F7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    227500
 3D Structure    ModBase 3D Structure for P08709
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 Clonality    Monoclonal
 Clone Number    219
 Host    Mouse
 Species Reactivity    This anitbody is specific for factor VII and does not crossreact with other vitamin K-dependent proteins.
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 Form/Format    Lyophilized from 10mM Sodium Phosphate, 0.15M NaCl, and 0.01% Sodium Azide, pH 7.4.Reconstitute with DI water to a concentration of 1.0 mg/ml.
 Concentration    500ug, lyophilized (lot specific)
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 Biological Significance    Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III).
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Factor VII antibody was raised in mouse using human factor VII as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of anti-F7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-F7 antibody

   Mouse monoclonal Factor VII antibody
 Product Categories/Family for anti-F7 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-F7 antibody   

User optimized

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NCBI/Uniprot data below describe general gene information for F7. It may not necessarily be applicable to this product.
 NCBI GI #    180334
 NCBI GeneID    2155
 NCBI Accession #    AAA51983.1 [Other Products]
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 UniProt Primary Accession #    P08709 [Other Products]
 UniProt Secondary Accession #    Q14339; Q5JVF1; Q5JVF2; Q9UD52; Q9UD53; Q9UD54; B0YJC8 [Other Products]
 UniProt Related Accession #    P08709 [Other Products]
 Molecular Weight    49,320 Da [Similar Products]
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 NCBI Official Full Name    factor VII
 NCBI Official Synonym Full Names    coagulation factor VII (serum prothrombin conversion accelerator)
 NCBI Official Symbol    F7 [Similar Products]
 NCBI Official Synonym Symbols   
SPCA
[Similar Products]
 NCBI Protein Information    coagulation factor VII
 UniProt Protein Name    Coagulation factor VII
 UniProt Synonym Protein Names   
Proconvertin; Serum prothrombin conversion accelerator; SPCA
 Protein Family    Factor VIII intron 22 protein
 UniProt Gene Name    F7 [Similar Products]
 UniProt Synonym Gene Names    SPCA [Similar Products]
 UniProt Entry Name    FA7_HUMAN
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 NCBI Summary for F7    This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for F7    F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.4.21.21; Secreted, signal peptide; Apoptosis; Secreted; Protease

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane; vesicle

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding

Biological Process: circadian rhythm; organ regeneration; positive regulation of positive chemotaxis; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; proteolysis; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; response to vitamin K; response to estrogen stimulus; blood coagulation; positive regulation of cell migration

Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency
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 Research Articles on F7    1. Two heterozygous mutations of F7, g.11349G>A and g.11482T>G, is associated with hereditary coagulation factor deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-F7 antibodyPathways associated with anti-F7 antibody
 Reference Product  PubMed Publications
 F10 antibody  >27 publications with F7 and F10
 APOB antibody  >4 publications with F7 and APOB
 VWF antibody  >4 publications with F7 and VWF
 GGCX antibody  >4 publications with F7 and GGCX
 TFPI antibody  >1 publications with F7 and TFPI
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway Of Fibrin Clot Formation antibodies  Extrinsic Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
Diseases associated with anti-F7 antibodyOrgans/Tissues associated with anti-F7 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >72 publications with F7 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >57 publications with F7 and Vascular Diseases
 Factor VII Deficiency Antibodies  >47 publications with F7 and Factor VII Deficiency
 Hemorrhagic Disorders Antibodies  >44 publications with F7 and Hemorrhagic Disorders
 Heart Diseases Antibodies  >33 publications with F7 and Heart Diseases
 Thrombosis Antibodies  >22 publications with F7 and Thrombosis
 Coronary Disease Antibodies  >18 publications with F7 and Coronary Disease
 Hemorrhage Antibodies  >15 publications with F7 and Hemorrhage
 Hypertension Antibodies  >15 publications with F7 and Hypertension
 Stroke Antibodies  >15 publications with F7 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >181 publications with F7 and Brain
 Liver Antibodies  >33 publications with F7 and Liver
 Testis Antibodies  >5 publications with F7 and Testis
 Mammary Gland Antibodies  >1 publications with F7 and Mammary Gland
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