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anti-FASLG antibody :: Mouse anti-Human Fas Ligand (CD178) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS670167 anti-FASLG antibody
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fas Ligand (CD178) (FASLG), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human Fas Ligand-UNLB

 Product Synonym Names    Mouse Anti-Human Fas Ligand - Purified, Unlabeled Antibody; Mouse anti-Human Fas Ligand (CD178)
 Product Gene Name   

anti-FASLG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (172628185..172636013). Location: 1q23
 OMIM    134638
 3D Structure    ModBase 3D Structure for P48023
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 Clonality    Monoclonal
 Isotype    Mouse IgG2b
 Clone Number    SB93a1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Reacts with native and recombinant human Fas Ligand1
Fas Ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells2,3. Moreover, studies indicate that Fas Ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death4. Fas Ligand initiates apoptosis by binding to its receptor (CD95) on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase- 85.
The SB93a monoclonal antibody detects a band at ~40 kD, corresponding to the transmembrane (insoluble) form of Fas Ligand.
 Form/Format    Purified (UNLB) Antibody
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 Immunogen    Recombinant human Fas Ligand
 Characterization    To ensure acceptable performance, each batch of product is tested by Flow Cytometry and/or Western blotting to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.1mg purified immunoglobulin in 0.2mL of 100 mM borate buffered saline, pH 8.0; store at 2-8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.1mg in 0.2mL of PBS/NaN3. Store at 2- 8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
 Other Notes    Small volumes of anti-FASLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FASLG antibody   

Flow Cytometry; Immunoprecipitation; Western Blot

 Application Notes for anti-FASLG antibody    Flow Cytometry Suggested Dilution: <= 1 uL/10^6 cells
Western Blot Suggested Dilution: 0.5-2 ug
Immunoprecipitation Suggested Dilution: 5-20 ug
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NCBI/Uniprot data below describe general gene information for FASLG. It may not necessarily be applicable to this product.
 NCBI GI #    17028381
 NCBI GeneID    356
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 UniProt Primary Accession #    P48023 [Other Products]
 UniProt Secondary Accession #    Q9BZP9 [Other Products]
 UniProt Related Accession #    P48023; Q0VHD7; Q53ZZ1 [Other Products]
 Molecular Weight    31,485 Da [Similar Products]
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 NCBI Official Full Name    Fas ligand (TNF superfamily, member 6)
 NCBI Official Synonym Full Names    Fas ligand (TNF superfamily, member 6)
 NCBI Official Symbol    FASLG [Similar Products]
 NCBI Official Synonym Symbols   
FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 6
 UniProt Synonym Protein Names   
Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    FASLG [Similar Products]
 UniProt Synonym Gene Names    APT1LG1; CD95L; FASL; TNFSF6 [Similar Products]
 UniProt Entry Name    TNFL6_HUMAN
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 NCBI Summary for FASLG    The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq]
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 UniProt Comments for FASLG    Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Subunit structure: Homotrimer

Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Ref.12

Subcellular location: Cell membrane; Single-pass type II membrane protein. Secreted. Note: May be released into the extracellular fluid, probably by cleavage form the cell surface.

Post-translational modification: N-glycosylated.The soluble form derives from the membrane form by proteolytic processing.

Involvement in disease: Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [

MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. Ref.9

Sequence similarities: Belongs to the tumor necrosis factor family.
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Product References and Citations for anti-FASLG antibody

   1) Trambas, C.M. and Griffiths, G.M. (2003) Nat. Immunol. 4:399-403.
3) Voss, M. et al. (2008). Cell. Commun. Signal. 6:11.
4) Krammer, P.H. (2000). Nature. 407:789-95..
5) Peter, M.E. and Krammer, P.H. (2002). Cell. Death Diff. 10:26-35.
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 Research Articles on FASLG    1. polymorphisms of FAS LG, FAS promoter and TP53 may have a role in increased risk of coronary artery disease progression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FASLG antibodyPathways associated with anti-FASLG antibody
 Reference Product  PubMed Publications
 FAS antibody  >3430 publications with FASLG and FAS
 FADD antibody  >195 publications with FASLG and FADD
 SRC antibody  >24 publications with FASLG and SRC
 TNFRSF6B antibody  >20 publications with FASLG and TNFRSF6B
 PTPN13 antibody  >15 publications with FASLG and PTPN13
 LCK antibody  >11 publications with FASLG and LCK
 DAXX antibody  >9 publications with FASLG and DAXX
 EGR2 antibody  >8 publications with FASLG and EGR2
 EGR3 antibody  >7 publications with FASLG and EGR3
 FYN antibody  >6 publications with FASLG and FYN
 Products by Pathway  Pathway Diagram
 Activation Of Pro-Caspase 8 Pathway antibodies  Activation Of Pro-Caspase 8 Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
Diseases associated with anti-FASLG antibodyOrgans/Tissues associated with anti-FASLG antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1212 publications with FASLG and Neoplasms
 Autoimmune Diseases Antibodies  >328 publications with FASLG and Autoimmune Diseases
 Leukemia Antibodies  >230 publications with FASLG and Leukemia
 Inflammation Antibodies  >219 publications with FASLG and Inflammation
 Adenocarcinoma Antibodies  >214 publications with FASLG and Adenocarcinoma
 Neuroectodermal Tumors Antibodies  >176 publications with FASLG and Neuroectodermal Tumors
 Nervous System Diseases Antibodies  >161 publications with FASLG and Nervous System Diseases
 Lymphoma Antibodies  >157 publications with FASLG and Lymphoma
 Lung Diseases Antibodies  >144 publications with FASLG and Lung Diseases
 Cardiovascular Diseases Antibodies  >134 publications with FASLG and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1687 publications with FASLG and Blood
 Bone Marrow Antibodies  >107 publications with FASLG and Bone Marrow
 Intestine Antibodies  >61 publications with FASLG and Intestine
 Prostate Antibodies  >57 publications with FASLG and Prostate
 Spleen Antibodies  >54 publications with FASLG and Spleen
 Uterus Antibodies  >49 publications with FASLG and Uterus
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