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anti-FASLG antibody :: Mouse anti-Human Fas Ligand Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS840017
Testing Data
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fas Ligand (FASLG), Monoclonal Antibody

★Popular Item★
 Also Known As   

Fas Ligand Antibody (Clone I-6060)

 Product Synonym Names    FASLG; FASL; FasL; CD95L; APT1LG1; CD178; APTL; TNFSF6
 Product Gene Name   

anti-FASLG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    134638
 3D Structure    ModBase 3D Structure for P48023
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    I-6060
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Affinity purified
 Form/Format    100 ug (0.5 mg/ml) Protein G purified mouse monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
 Concentration    0.5 mg/ml (lot specific)
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 Appearance    Colorless liquid
 Immunogen    Recombinant human Fas Ligand
 Handling    The antibody solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C. For long-term storeage, aliquot and freeze at -70 degree C. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-FASLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FASLG antibody

   Background: Fas (APO-1, CD95) is a 45 kDa cell surface protein that mediates apoptosis when cross-linked with agonistic anti-Fas antibodies or Fas ligand (FasL). FasL is a tumor necrosis factor (TNF)-related type II membrane protein and is expressed in various tissue and cells. Both Fas and FasL are thomught to play an important role in the apoptosis processes that takes place during T cell development.
 Applications Tested/Suitable for anti-FASLG antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)

 Application Notes for anti-FASLG antibody    Western blotting (1-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control and an approximately 40 kDa band should be detected by Western blotting.
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 Testing Data of anti-FASLG antibody    anti-FASLG antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for FASLG. It may not necessarily be applicable to this product.
 NCBI GI #    4557329
 NCBI GeneID    356
 NCBI Accession #    NP_000630.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000639.2 [Other Products]
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 UniProt Primary Accession #    P48023 [Other Products]
 UniProt Secondary Accession #    Q9BZP9 [Other Products]
 UniProt Related Accession #    P48023 [Other Products]
 Molecular Weight    14,006 Da [Similar Products]
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 6 isoform 1
 NCBI Official Synonym Full Names    Fas ligand (TNF superfamily, member 6)
 NCBI Official Symbol    FASLG [Similar Products]
 NCBI Official Synonym Symbols   
APTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; APT1LG1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 6
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 6
 UniProt Synonym Protein Names   
Apoptosis antigen ligand; APTL
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    FASLG [Similar Products]
 UniProt Synonym Gene Names    APT1LG1; CD95L; FASL; TNFSF6; APTL; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA [Similar Products]
 UniProt Entry Name    TNFL6_HUMAN
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 NCBI Summary for FASLG    This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
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 UniProt Comments for FASLG    FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: lysosomal lumen; extracellular space; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; extracellular region; caveola; nucleus; external side of plasma membrane

Molecular Function: protein binding; death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; signal transduction; cellular chloride ion homeostasis; endosomal lumen acidification; inflammatory cell apoptosis; negative regulation of angiogenesis; cell-cell signaling; induction of apoptosis via death domain receptors; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptosis; positive regulation of cell proliferation; immune response; retinal cell programmed cell death

Disease: Lung Cancer; Autoimmune Lymphoproliferative Syndrome
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 Research Articles on FASLG    1. during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FASLG antibodyDiseases associated with anti-FASLG antibody
 Reference Product  PubMed Publications
 FAS antibody  >3623 publications with FASLG and FAS
 CASP8 antibody  >413 publications with FASLG and CASP8
 JUN antibody  >404 publications with FASLG and JUN
 FADD antibody  >202 publications with FASLG and FADD
 CFLAR antibody  >85 publications with FASLG and CFLAR
 BID antibody  >60 publications with FASLG and BID
 CASP10 antibody  >21 publications with FASLG and CASP10
 TNFRSF6B antibody  >21 publications with FASLG and TNFRSF6B
 MAPK8 antibody  >11 publications with FASLG and MAPK8
 FYN antibody  >6 publications with FASLG and FYN
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >986 publications with FASLG and Necrosis
 Inflammation Antibodies  >240 publications with FASLG and Inflammation
 Liver Diseases Antibodies  >220 publications with FASLG and Liver Diseases
 Nervous System Diseases Antibodies  >167 publications with FASLG and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >141 publications with FASLG and Cardiovascular Diseases
 Hepatitis Antibodies  >130 publications with FASLG and Hepatitis
 Breast Neoplasms Antibodies  >94 publications with FASLG and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >93 publications with FASLG and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >88 publications with FASLG and Lung Neoplasms
 Melanoma Antibodies  >79 publications with FASLG and Melanoma
Organs/Tissues associated with anti-FASLG antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1790 publications with FASLG and Blood
 Bone Marrow Antibodies  >119 publications with FASLG and Bone Marrow
 Intestine Antibodies  >63 publications with FASLG and Intestine
 Prostate Antibodies  >60 publications with FASLG and Prostate
 Uterus Antibodies  >55 publications with FASLG and Uterus
 Spleen Antibodies  >54 publications with FASLG and Spleen
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