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anti-FCER1A antibody :: Mouse Fc EPSILON R1 ALPHA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212740
Testing Data
Unit / Price
0.2 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fc EPSILON R1 ALPHA (FCER1A), Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN FC EPSILON R1 ALPHA

 Product Gene Name   

anti-FCER1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147140
 3D Structure    ModBase 3D Structure for P12319
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9E1
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Fusion Partners    Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-FCER1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FCER1A antibody

   Mouse anti Human Fc epsilon R1 alpha antibody, clone 9E1 recognizes the human high affinity Fc receptor for IgE (Fc epsilon R1), which plays a central role in the IgE-mediated allergic response. Fc epsilon R1 consists of four subunits, a high affinity IgE binding alpha subunit, a beta chain and two di-sulphide linked gamma subunits. Clone 9E1 specifically recognizes the extracellular D1 domain of the Fc epsilon R1 alpha chain. Fc epsilon R1 is primarily expressed on mast cells and basophils but expression of Fc epsilon R1 has also been reported on monocytes, Langerhans cells and dendritic cells from patients with atopic diseases.
 Applications Tested/Suitable for anti-FCER1A antibody   

ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-FCER1A antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50
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 Testing Data of anti-FCER1A antibody    Staining of human peripheral blood cells with Mouse anti Human FC Epsilon R1, showing staining of eosinophils
anti-FCER1A antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for FCER1A. It may not necessarily be applicable to this product.
 NCBI GI #    4503675
 NCBI GeneID    2205
 NCBI Accession #    NP_001992.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002001.3 [Other Products]
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 UniProt Primary Accession #    P12319 [Other Products]
 UniProt Related Accession #    P12319 [Other Products]
 Molecular Weight    29,596 Da [Similar Products]
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 NCBI Official Full Name    high affinity immunoglobulin epsilon receptor subunit alpha
 NCBI Official Synonym Full Names    Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
 NCBI Official Symbol    FCER1A [Similar Products]
 NCBI Official Synonym Symbols   
FCE1A; FcERI
[Similar Products]
 NCBI Protein Information    high affinity immunoglobulin epsilon receptor subunit alpha; Fc IgE receptor, alpha polypeptide; Fc epsilon RI alpha-chain; Fc-epsilon RI-alpha; high affinity immunoglobulin epsilon receptor alpha-subunit; igE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
 UniProt Protein Name    High affinity immunoglobulin epsilon receptor subunit alpha
 UniProt Synonym Protein Names   
Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
 Protein Family    High affinity immunoglobulin epsilon receptor
 UniProt Gene Name    FCER1A [Similar Products]
 UniProt Synonym Gene Names    FCE1A; FcERI [Similar Products]
 UniProt Entry Name    FCERA_HUMAN
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 NCBI Summary for FCER1A    The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
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 UniProt Comments for FCER1A    Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
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 Research Articles on FCER1A    1. FCER2 polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A SNP rs2427837.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FCER1A antibodyPathways associated with anti-FCER1A antibody
 Reference Product  PubMed Publications
 MS4A2 antibody  >9 publications with FCER1A and MS4A2
 FCER1G antibody  >5 publications with FCER1A and FCER1G
 SYK antibody  >2 publications with FCER1A and SYK
 FYN antibody  >1 publications with FCER1A and FYN
 LYN antibody  >1 publications with FCER1A and LYN
 IGHE antibody  >1 publications with FCER1A and IGHE
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-FCER1A antibodyOrgans/Tissues associated with anti-FCER1A antibody
 Disease Name  Pubmed Publications
 Asthma Antibodies  >22 publications with FCER1A and Asthma
 Respiratory Tract Diseases Antibodies  >19 publications with FCER1A and Respiratory Tract Diseases
 Respiratory Hypersensitivity Antibodies  >17 publications with FCER1A and Respiratory Hypersensitivity
 Urticaria Antibodies  >14 publications with FCER1A and Urticaria
 Drug Hypersensitivity Antibodies  >9 publications with FCER1A and Drug Hypersensitivity
 Inflammation Antibodies  >8 publications with FCER1A and Inflammation
 Rhinitis Antibodies  >6 publications with FCER1A and Rhinitis
 Angioedema Antibodies  >4 publications with FCER1A and Angioedema
 Necrosis Antibodies  >3 publications with FCER1A and Necrosis
 Carcinoma Antibodies  >2 publications with FCER1A and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with FCER1A and Lung
 Bone Antibodies  >4 publications with FCER1A and Bone
 Bone Marrow Antibodies  >4 publications with FCER1A and Bone Marrow
 Brain Antibodies  >3 publications with FCER1A and Brain
 Kidney Antibodies  >1 publications with FCER1A and Kidney
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