NP_005238.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,887 Da
NCBI Official Full Name
fibroblast growth factor 3
NCBI Official Synonym Full Names
fibroblast growth factor 3
NCBI Official Synonym Symbols
NCBI Protein Information
fibroblast growth factor 3
UniProt Protein Name
Fibroblast growth factor 3
UniProt Synonym Protein Names
Heparin-binding growth factor 3; HBGF-3; Proto-oncogene Int-2
UniProt Synonym Gene Names
NCBI Summary for FGF3
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF3
FGF3: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM); also known as congenital deafness with inner ear agenesis, microtia and microdontia. LAMM consists of a unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia). Belongs to the heparin-binding growth factors family.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: extracellular region
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: anatomical structure morphogenesis; cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of cardiac muscle development; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade; signal transduction
Disease: Deafness, Congenital, With Inner Ear Agenesis, Microtia, And Microdontia
Research Articles on FGF3
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Products associated with anti-FGF3 antibody
Pathways associated with anti-FGF3 antibody
Diseases associated with anti-FGF3 antibody
Organs/Tissues associated with anti-FGF3 antibody
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