P02751.4
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
256,502 Da
NCBI Official Full Name
Fibronectin
NCBI Official Synonym Full Names
fibronectin 1
NCBI Official Synonym Symbols
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2 [Similar Products]
NCBI Protein Information
fibronectin; cold-insoluble globulin; migration-stimulating factor
UniProt Protein Name
Fibronectin
UniProt Synonym Protein Names
Cold-insoluble globulin; CIG
UniProt Synonym Gene Names
UniProt Entry Name
FINC_HUMAN
NCBI Summary for FN1
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for FN1
FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: extracellular matrix; extracellular space; apical plasma membrane; fibrinogen complex; ER-Golgi intermediate compartment; extracellular region; basal lamina
Molecular Function: collagen binding; heparin binding; integrin binding; protein binding; protease activator activity; protease binding
Biological Process: integrin activation; platelet activation; extracellular matrix organization and biogenesis; positive regulation of axon extension; extracellular matrix disassembly; regulation of cell shape; platelet degranulation; acute-phase response; cell-substrate junction assembly; response to wounding; calcium-independent cell-matrix adhesion; peptide cross-linking; angiogenesis; blood coagulation; cell adhesion; leukocyte migration
Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency
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Pathways associated with anti-FN1 antibody
Diseases associated with anti-FN1 antibody
Organs/Tissues associated with anti-FN1 antibody
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