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anti-FN1 antibody :: Mouse Fibronectin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438210
Immunohistochemistry
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibronectin (FN1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Fibronectin

 Product Synonym Names    Cold insoluble globulin (CIG); FINC; FN1; FNZ; GFND; GFND2; LETS; Migration stimulating factor (MSF); Ugl-Y3
 Product Gene Name   

anti-FN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 601894
 3D Structure    ModBase 3D Structure for P02751
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    TV-1
 Host    Mouse
 Species Reactivity    Human, Pig, Mouse and Rat. Others-not known.
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 Specificity    Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix, and blood. This MAb reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this MAb localizes to tumor vessels where it binds to the underlying basement. Epitope recognized by this antibody is not accessible in normal tissues to the circulating MAb indicating that it can be used to specifically target tumor vessels in vivo. TV-1 is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or MAbs.
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 Cellular Localization    Connective tissue matrix
 Positive Control    SW156 cells or Kidney
 Human Chromosomal Location    2q35
 Immunogen    T-cell lymphoma biopsy
 Quantity and Buffer    0.5 ml at 200ug/ml with BSA and azide
 Supplied As    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-FN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FN1 antibody   

ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

 Application Notes for anti-FN1 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml) Immunofluorescence (0.5-1ug/ml) Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
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 Immunohistochemistry of anti-FN1 antibody    Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody (TV-1)
anti-FN1 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for FN1. It may not necessarily be applicable to this product.
 NCBI GI #    16933542
 NCBI GeneID    2335
 NCBI Accession #    NP_002017.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002026.2 [Other Products]
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 UniProt Primary Accession #    P02751 [Other Products]
 UniProt Secondary Accession #    O95609; O95610; Q14312; Q14325; Q14326; Q17RV7; Q564H7; Q585T2; B7ZLF0; E9PE77; E9PG29 [Other Products]
 UniProt Related Accession #    P02751 [Other Products]
 Molecular Weight    220kDa (monomer); 440kDa (dimer)
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 NCBI Official Full Name    fibronectin isoform 3 preproprotein
 NCBI Official Synonym Full Names    fibronectin 1
 NCBI Official Symbol    FN1 [Similar Products]
 NCBI Official Synonym Symbols   
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
[Similar Products]
 NCBI Protein Information    fibronectin; cold-insoluble globulin; migration-stimulating factor
 UniProt Protein Name    Fibronectin
 UniProt Synonym Protein Names   
Cold-insoluble globulin; CIG
 Protein Family    Fibronectin
 UniProt Gene Name    FN1 [Similar Products]
 UniProt Synonym Gene Names    FN; FN; CIG [Similar Products]
 UniProt Entry Name    FINC_HUMAN
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 NCBI Summary for FN1    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FN1    FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: extracellular matrix; extracellular space; apical plasma membrane; fibrinogen complex; ER-Golgi intermediate compartment; extracellular region; basal lamina

Molecular Function: collagen binding; heparin binding; integrin binding; protein binding; protease activator activity; protease binding

Biological Process: integrin activation; platelet activation; extracellular matrix organization and biogenesis; positive regulation of axon extension; extracellular matrix disassembly; regulation of cell shape; platelet degranulation; calcium-independent cell-matrix adhesion; cell-substrate junction assembly; acute-phase response; response to wounding; peptide cross-linking; angiogenesis; cell adhesion; blood coagulation; leukocyte migration

Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency
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Product References and Citations for anti-FN1 antibody

   1. Epstein AL, et. al. Cancer Research, 1995, 55(12):2673-80.
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 Research Articles on FN1    1. Perturbing the mesenchymal regulators, platelet-derived growth factor (PDGF) receptors or fibronectin, reverts mesenchymal stromal/stem cells (MSCs) toward mesodermal progenitors with endothelial potential.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FN1 antibodyDiseases associated with anti-FN1 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Fibronectin Matrix Formation Pathway antibodies  Fibronectin Matrix Formation Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >61 publications with FN1 and Carcinoma
 Fibrosis Antibodies  >23 publications with FN1 and Fibrosis
 Lung Diseases Antibodies  >22 publications with FN1 and Lung Diseases
 Inflammation Antibodies  >16 publications with FN1 and Inflammation
 Lung Neoplasms Antibodies  >16 publications with FN1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >15 publications with FN1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >15 publications with FN1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >14 publications with FN1 and Kidney Diseases
 Diabetes Mellitus Antibodies  >10 publications with FN1 and Diabetes Mellitus
 Liver Diseases Antibodies  >8 publications with FN1 and Liver Diseases
Organs/Tissues associated with anti-FN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with FN1 and Blood
 Lung Antibodies  >26 publications with FN1 and Lung
 Muscle Antibodies  >24 publications with FN1 and Muscle
 Kidney Antibodies  >24 publications with FN1 and Kidney
 Liver Antibodies  >22 publications with FN1 and Liver
 Bone Antibodies  >21 publications with FN1 and Bone
 Embryonic Tissue Antibodies  >19 publications with FN1 and Embryonic Tissue
 Vascular Antibodies  >19 publications with FN1 and Vascular
 Brain Antibodies  >17 publications with FN1 and Brain
 Skin Antibodies  >15 publications with FN1 and Skin
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