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anti-FBLN5 antibody :: Fibulin 5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS769358
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibulin 5 (FBLN5), Monoclonal Antibody

 Also Known As   

Fibulin 5 Mouse Monoclonal

 Product Synonym Names    ARMD3, DANCE, EVEC, FBLN5, FIBL 5, fibulin 5, FLJ90059, UP50, Urine p50 protein
 Product Gene Name   

anti-FBLN5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    219100
 3D Structure    ModBase 3D Structure for Q9UBX5
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 Clonality    Monoclonal
 Isotype    IgG2a
 Species Reactivity    Human, Mouse
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 Specificity    Human; Mouse; other species are not tested. Please decide the specificity by homology
 Purity/Purification    >=95% as determined by SDS-PAGE
Protein A+G purification
 Form/Format    Liquid
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 Immunogen    Fibulin 5
 Host    Rabbit
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 Preparation and Storage    PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FBLN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FBLN5 antibody

   Fibulin-5, also known as EVEC and DANCE, is an extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cell through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies.
 Applications Tested/Suitable for anti-FBLN5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-FBLN5 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
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 Immunohistochemistry of anti-FBLN5 antibody    Immunohistochemical of paraffin-embedded human heart using MBS769358(FBLN5 antibody) at dilution of 1 :50
anti-FBLN5 antibody Immunohistochemistry (IHC) image
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 Immunofluorescence of anti-FBLN5 antibody    Immunofluorescent analysis of ( -20C Ethanol ) fixed HeLa cells using MBS769358 ( FBLN5 Antibody) at dilution of 1 :50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)
anti-FBLN5 antibody Immunofluorescence image
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 Western Blot of anti-FBLN5 antibody    MCF7 cells were subjected to SDS PAGE followed by western blot with MBS769358(FBLN5 antibody) at dilution of 1:500
anti-FBLN5 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for FBLN5. It may not necessarily be applicable to this product.
 NCBI GI #    19743803
 NCBI GeneID    10516
 NCBI Accession #    NP_006320.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006329.3 [Other Products]
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 UniProt Primary Accession #    Q9UBX5 [Other Products]
 UniProt Secondary Accession #    O75966; Q6IAL4; Q6UWA3 [Other Products]
 UniProt Related Accession #    Q9UBX5 [Other Products]
 Molecular Weight    50kDa [Similar Products]
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 NCBI Official Full Name    fibulin-5
 NCBI Official Synonym Full Names    fibulin 5
 NCBI Official Symbol    FBLN5 [Similar Products]
 NCBI Official Synonym Symbols   
EVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5; HNARMD
[Similar Products]
 NCBI Protein Information    fibulin-5
 UniProt Protein Name    Fibulin-5
 UniProt Synonym Protein Names   
Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
 Protein Family    Fibulin
 UniProt Gene Name    FBLN5 [Similar Products]
 UniProt Synonym Gene Names    DANCE; FIBL-5; Dance; UP50 [Similar Products]
 UniProt Entry Name    FBLN5_HUMAN
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 NCBI Summary for FBLN5    The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBLN5    FBLN5: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Defects in FBLN5 are the cause of cutis laxa, autosomal dominant, type 2 (ADCL2). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in FBLN5 are a cause of cutis laxa, autosomal recessive, type 1A (ARCL1A). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3). ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the fibulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; integrin binding; protein binding; protein C-terminus binding; protein homodimerization activity

Biological Process: cell-matrix adhesion; elastic fiber assembly; extracellular matrix organization and biogenesis; regulation of cell growth; secretion

Disease: Cutis Laxa, Autosomal Dominant 2; Cutis Laxa, Autosomal Recessive, Type Ia; Macular Degeneration, Age-related, 3
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 Research Articles on FBLN5    1. Fibulin-5 is significantly down-regulated in ovarian carcinoma and acts as a tumour suppressor by inhibiting the migration and invasion of ovarian cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Fibulin 5 Mouse Monoclonal
 Catalog #  Product Name  Catalog #  Product Name
 MBS2024100  Fibulin 5 (FBLN5) ELISA Kit  MBS2014531  FITC-linked Antibody to Fibulin 5 (FBLN5)
 MBS071769  Donkey Fibulin 5 ELISA Kit  MBS2003794  Polyclonal Antibody to Fibulin 5 (FBLN5)
 MBS2070269  FITC-Linked Polyclonal Antibody to Fibulin 5 (FBLN5)  MBS2070259  FITC-Linked Polyclonal Antibody to Fibulin 5 (FBLN5)
 MBS2070273  APC/CY7-Linked Polyclonal Antibody to Fibulin 5 (FBLN5)  MBS716433  Rabbit anti-human fibulin 5 polyclonal Antibody
 MBS925731  Mouse Fibulin-5, FBLN5 ELISA Kit  MBS2070258  Cy3-Linked Polyclonal Antibody to Fibulin 5 (FBLN5)
Products associated with anti-FBLN5 antibodyPathways associated with anti-FBLN5 antibody
 Reference Product  PubMed Publications
 FBN1 antibody  >18 publications with FBLN5 and FBN1
 LOXL1 antibody  >14 publications with FBLN5 and LOXL1
 FBLN1 antibody  >2 publications with FBLN5 and FBLN1
 FBN2 antibody  >2 publications with FBLN5 and FBN2
 MFAP4 antibody  >2 publications with FBLN5 and MFAP4
 EFEMP2 antibody  >2 publications with FBLN5 and EFEMP2
 SOD3 antibody  >1 publications with FBLN5 and SOD3
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
Diseases associated with anti-FBLN5 antibodyOrgans/Tissues associated with anti-FBLN5 antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >14 publications with FBLN5 and Vascular Diseases
 Lung Diseases Antibodies  >14 publications with FBLN5 and Lung Diseases
 Heart Diseases Antibodies  >10 publications with FBLN5 and Heart Diseases
 Disease Models, Animal Antibodies  >10 publications with FBLN5 and Disease Models, Animal
 Emphysema Antibodies  >9 publications with FBLN5 and Emphysema
 Fibrosis Antibodies  >8 publications with FBLN5 and Fibrosis
 Inflammation Antibodies  >7 publications with FBLN5 and Inflammation
 Neoplasm Metastasis Antibodies  >6 publications with FBLN5 and Neoplasm Metastasis
 Lung Injury Antibodies  >6 publications with FBLN5 and Lung Injury
 Cell Transformation, Neoplastic Antibodies  >5 publications with FBLN5 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >62 publications with FBLN5 and Connective Tissue
 Skin Antibodies  >46 publications with FBLN5 and Skin
 Vascular Antibodies  >45 publications with FBLN5 and Vascular
 Muscle Antibodies  >29 publications with FBLN5 and Muscle
 Lung Antibodies  >28 publications with FBLN5 and Lung
 Embryonic Tissue Antibodies  >13 publications with FBLN5 and Embryonic Tissue
 Heart Antibodies  >13 publications with FBLN5 and Heart
 Eye Antibodies  >10 publications with FBLN5 and Eye
 Bone Antibodies  >9 publications with FBLN5 and Bone
 Brain Antibodies  >7 publications with FBLN5 and Brain
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