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anti-FLNB antibody :: Mouse Filamin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531705 anti-FLNB antibody
Unit / Price
0.1 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Filamin (FLNB), Monoclonal Antibody

★Popular Item★
 Also Known As   

Filamin antibody

 Product Synonym Names    Monoclonal Filamin; Anti-Filamin
 Product Gene Name   

anti-FLNB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    108720
 3D Structure    ModBase 3D Structure for O75369
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    PM6/317
 Host    Mouse
 Species Reactivity    Chicken, Guinea Pig, Human, Rabbit, Rat
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 Purity/Purification    Filamin antibody was purified by affniity chromatography.
 Form/Format    Protein A purified and supplied in PBS with 1 mg/ml BSA, and 10mM NaN3.
 Concentration    0.1 mg/ml (lot specific)
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 Biological Significance    Filamin is a structural protein that forms flexible cross-links between two actin filaments. Filamin is a homodimer of polypeptide chains each joined to the other at one end with an actin binding site ath the other. It is present in smooth muscle, fibroblasts, platelets and lymphocytes.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
 Immunogen    Filamin antibody was raised in mouse using platelet filamin as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-FLNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FLNB antibody

   Mouse monoclonal Filamin antibody
 Product Categories/Family for anti-FLNB antibody    Cancer
 Applications Tested/Suitable for anti-FLNB antibody   

Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

 Application Notes for anti-FLNB antibody    WB: 1:1,000-1:4,000
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NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.
 NCBI GI #    8100574
 NCBI GeneID    2317
 NCBI Accession #    AAF72339.1 [Other Products]
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 UniProt Primary Accession #    O75369 [Other Products]
 UniProt Secondary Accession #    Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4 [Other Products]
 UniProt Related Accession #    O75369 [Other Products]
 Molecular Weight    276,939 Da [Similar Products]
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 NCBI Official Full Name    filamin
 NCBI Official Synonym Full Names    filamin B, beta
 NCBI Official Symbol    FLNB [Similar Products]
 NCBI Official Synonym Symbols   
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
[Similar Products]
 NCBI Protein Information    filamin-B
 UniProt Protein Name    Filamin-B
 UniProt Synonym Protein Names   
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
 Protein Family    Filamin
 UniProt Gene Name    FLNB [Similar Products]
 UniProt Synonym Gene Names    FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP [Similar Products]
 UniProt Entry Name    FLNB_HUMAN
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 NCBI Summary for FLNB    This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
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 UniProt Comments for FLNB    FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: focal adhesion; cytoplasm; integral to membrane; stress fiber; plasma membrane; cell cortex; cytosol; Z disc; actin cytoskeleton

Molecular Function: identical protein binding; protein binding; actin binding

Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; actin cytoskeleton organization and biogenesis; cell differentiation; signal transduction

Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii
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 Research Articles on FLNB    1. Polymorphism at rs11720285, rs11130605 and rs9809315, all of which are located either 5' of the transcription start site or in intron 1 of the FLNB gene has been identified as significantly associated with BMD in Caucasian women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FLNB antibodyDiseases associated with anti-FLNB antibody
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >20 publications with FLNB and Congenital Abnormalities
 Spondylocarpotarsal synostosis Antibodies  >7 publications with FLNB and Spondylocarpotarsal synostosis
 Boomerang dysplasia Antibodies  >6 publications with FLNB and Boomerang dysplasia
 Nervous System Diseases Antibodies  >5 publications with FLNB and Nervous System Diseases
 Liver Neoplasms Antibodies  >3 publications with FLNB and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with FLNB and Liver Diseases
 Adenocarcinoma Antibodies  >3 publications with FLNB and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with FLNB and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >2 publications with FLNB and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with FLNB and Hypertrophy
Organs/Tissues associated with anti-FLNB antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with FLNB and Bone
 Connective Tissue Antibodies  >7 publications with FLNB and Connective Tissue
 Heart Antibodies  >4 publications with FLNB and Heart
 Blood Antibodies  >4 publications with FLNB and Blood
 Vascular Antibodies  >4 publications with FLNB and Vascular
 Brain Antibodies  >4 publications with FLNB and Brain
 Nerve Antibodies  >3 publications with FLNB and Nerve
 Muscle Antibodies  >3 publications with FLNB and Muscle
 Liver Antibodies  >3 publications with FLNB and Liver
 Embryonic Tissue Antibodies  >2 publications with FLNB and Embryonic Tissue
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