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anti-FSHB antibody :: anti-Human Follicle Stimulating Hormone (FSH) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311615 anti-FSHB antibody
Unit / Price
1 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Follicle Stimulating Hormone (FSH) (FSHB), Monoclonal Antibody

 Also Known As   

MAb to FSH

 Product Synonym Names    Monoclonal Antibody to Human Follicle Stimulating Hormone (FSH)
 Product Gene Name   

anti-FSHB antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Follicle Stimulating Hormone (FSH) Clone #090-10264 (MBS311616)
Detection Antibody: Follicle Stimulating Hormone (FSH) Clone #090-10243 (MBS311615)
 Matching Pairs    Capture Antibody: Follicle Stimulating Hormone (FSH) Clone #090-17275 (MBS311617)
Detection Antibody: Follicle Stimulating Hormone (FSH) Clone #090-10243 (MBS311615)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (30252563..30256824). Location: 11p13
 OMIM    136530
 3D Structure    ModBase 3D Structure for P01225
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    090-10243
 Host    Host: Mouse
Source: Ascites
 Species Reactivity    Human
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 Specificity    Follicle Stimulating Hormone (FSH)
FSH
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography
Product is 0.2um filtered.
 Form/Format    Purified, Liquid
 Concentration    5.3mg/ml (OD280nm, E^1% = 14) (lot specific)
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 Affinity Constant    2 x 10^9
 Buffer    10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    0.1% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FSHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-FSHB antibody    Monoclonal Antibodies to Hormones and Steroids
 Applications Tested/Suitable for anti-FSHB antibody   

EIA/ELISA, Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for FSHB. It may not necessarily be applicable to this product.
 NCBI GI #    182762
 NCBI GeneID    2488
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 UniProt Primary Accession #    P01225 [Other Products]
 UniProt Secondary Accession #    Q14D61; A2TF08; A5JVV3 [Other Products]
 UniProt Related Accession #    P01225; Q1W658; Q27RP3 [Other Products]
 Molecular Weight    14,700 Da [Similar Products]
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 NCBI Official Full Name    follicle-stimulating hormone
 NCBI Official Synonym Full Names    follicle stimulating hormone, beta polypeptide
 NCBI Official Symbol    FSHB [Similar Products]
 NCBI Protein Information    follitropin subunit beta; FSH-B; FSH-beta; OTTHUMP00000232881; OTTHUMP00000232882; follitropin beta chain; follitropin, beta chain; follicle-stimulating hormone beta subunit
 UniProt Protein Name    Follitropin subunit beta
 UniProt Synonym Protein Names   
Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
 Protein Family    Follitropin
 UniProt Gene Name    FSHB [Similar Products]
 UniProt Entry Name    FSHB_HUMAN
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 NCBI Summary for FSHB    The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq]
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 UniProt Comments for FSHB    Function: Stimulates development of follicle and spermatogenesis in the reproductive organs.

Subunit structure: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location: Secreted.

Involvement in disease: Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [

MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Ref.15 Ref.16 Ref.17

Pharmaceutical use: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.

Sequence similarities: Belongs to the glycoprotein hormones subunit beta family.
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 Research Articles on FSHB    1. FSH dysfunction due to a less acidic isoform pattern through hypoglycosylation is not a key mechanism of primary ovarian insufficiency in classic galactosemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FSHB antibodyPathways associated with anti-FSHB antibody
 Reference Product  PubMed Publications
 CGA antibody  >20 publications with FSHB and CGA
 FSHR antibody  >8 publications with FSHB and FSHR
 CGB antibody  >2 publications with FSHB and CGB
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amine And Peptide Hormones Pathway antibodies  Biosynthesis Of Amine And Peptide Hormones Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
Diseases associated with anti-FSHB antibodyOrgans/Tissues associated with anti-FSHB antibody
 Disease Name  Pubmed Publications
 Male Urogenital Diseases Antibodies  >15 publications with FSHB and Male Urogenital Diseases
 Neoplasms Antibodies  >14 publications with FSHB and Neoplasms
 Genetic Diseases, Inborn Antibodies  >13 publications with FSHB and Genetic Diseases, Inborn
 Female Urogenital Diseases Antibodies  >13 publications with FSHB and Female Urogenital Diseases
 Urologic Diseases Antibodies  >10 publications with FSHB and Urologic Diseases
 Kidney Diseases Antibodies  >9 publications with FSHB and Kidney Diseases
 Kidney Neoplasms Antibodies  >9 publications with FSHB and Kidney Neoplasms
 Congenital Abnormalities Antibodies  >8 publications with FSHB and Congenital Abnormalities
 Infertility Antibodies  >7 publications with FSHB and Infertility
 Eye Abnormalities Antibodies  >6 publications with FSHB and Eye Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >40 publications with FSHB and Brain
 Pituitary Gland Antibodies  >36 publications with FSHB and Pituitary Gland
 Testis Antibodies  >14 publications with FSHB and Testis
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