NP_002560.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
furin preproprotein
NCBI Official Synonym Full Names
furin (paired basic amino acid cleaving enzyme)
NCBI Protein Information
furin; FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furin, membrane associated receptor protein; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue-cleaving enzyme
UniProt Protein Name
Furin
UniProt Synonym Protein Names
Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme
UniProt Synonym Gene Names
UniProt Entry Name
FURIN_HUMAN
NCBI Summary for FURIN
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FURIN
FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: Vesicle; Cell surface; Membrane protein, integral; EC 3.4.21.75; Protease
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: Golgi membrane; extracellular space; trans-Golgi network transport vesicle; cell surface; membrane; Golgi lumen; integral to membrane; plasma membrane; trans-Golgi network; lipid raft
Molecular Function: serine-type endopeptidase inhibitor activity; peptidase activity; protease binding; serine-type endopeptidase activity; metal ion binding; endopeptidase activity; nerve growth factor binding; peptide binding
Biological Process: extracellular matrix organization and biogenesis; viral reproduction; nerve growth factor receptor signaling pathway; peptide hormone processing; regulation of signal transduction; pathogenesis; viral infectious cycle; proteolysis; positive regulation of membrane protein ectodomain proteolysis; peptide biosynthetic process; extracellular matrix disassembly; nerve growth factor processing; transforming growth factor beta receptor signaling pathway; regulation of endopeptidase activity; negative regulation of nerve growth factor production; secretion by cell; Notch signaling pathway; signal peptide processing; virus assembly; post-translational protein modification; peptidyl-glutamic acid carboxylation; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; cell proliferation; collagen catabolic process; cellular protein metabolic process; viral protein processing; regulation of protein catabolic process; protein processing; negative regulation of low-density lipoprotein receptor catabolic process
Research Articles on FURIN
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Products associated with anti-FURIN antibody
Pathways associated with anti-FURIN antibody
Diseases associated with anti-FURIN antibody
Organs/Tissues associated with anti-FURIN antibody
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