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anti-CSF3 antibody :: Rat anti-Human G-CSF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS670060 anti-CSF3 antibody
Unit / Price
0.5 mg  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G-CSF (CSF3), Monoclonal Antibody

 Also Known As   

Rat Anti-Human G-CSF-BIOT

 Product Synonym Names    Rat Anti-Human G-CSF - Biotin; Rat Anti-Human G-CSF
 Product Gene Name   

anti-CSF3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (38171614..38174066). Location: 17q11.2-q12
 OMIM    138970
 3D Structure    ModBase 3D Structure for P09919
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 Clonality    Monoclonal
 Isotype    Rat IgG2a kappa
 Clone Number    BVD11-37G10
 Host    Rat
 Species Reactivity    Human
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 Specificity    Human Granulocyte-Colony Stimulating Factor (G-CSF)1,2 (This is a neutralizing antibody.)
 Form/Format    Biotin (BIOT) Conjugate
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 Immunogen    E. coli-expressed recombinant human G-CSF
 Characterization    To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg labeled antibody in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
 Other Notes    Small volumes of anti-CSF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CSF3 antibody   

ELISA; Western Blot

 Application Notes for anti-CSF3 antibody    Research Application(s): ELISA Detection: BVD11-37G10 monoclonal antibody is useful as a detection antibody in a sandwich ELISA for quantifying human G-CSF protein levels.1,2 Biotinylated BVD11-37G10 antibody should be paired with a suitable purified antibody as the capture antibody, with purified recombinant human G-CSF as the standard.
Western Blotting: The purified BVD11-37G10 antibody is also useful for Western blotting applications. A concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig) has been found to enable detection of <= 100 ng/lane of recombinant human G-CSF under reducing conditions.
Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.
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NCBI/Uniprot data below describe general gene information for CSF3. It may not necessarily be applicable to this product.
 NCBI GI #    297660573
 NCBI GeneID    1440
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 UniProt Primary Accession #    P09919 [Other Products]
 UniProt Related Accession #    P09919; Q5FBY7; Q6FH65; Q8N4W3 [Other Products]
 Molecular Weight    22,293 Da [Similar Products]
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 NCBI Official Full Name    granulocyte colony-stimulating factor
 NCBI Official Synonym Full Names    colony stimulating factor 3 (granulocyte)
 NCBI Official Symbol    CSF3 [Similar Products]
 NCBI Official Synonym Symbols   
GCSF; CSF3OS; C17orf33; MGC45931
[Similar Products]
 NCBI Protein Information    granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin; OTTHUMP00000164325; OTTHUMP00000164326; OTTHUMP00000164327; OTTHUMP00000164328
 UniProt Protein Name    Granulocyte colony-stimulating factor
 UniProt Synonym Protein Names   
Pluripoietin
 Protein Family    Granulocyte colony-stimulating factor
 UniProt Gene Name    CSF3 [Similar Products]
 UniProt Synonym Gene Names    C17orf33; GCSF [Similar Products]
 UniProt Entry Name    CSF3_HUMAN
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 NCBI Summary for CSF3    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]
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 UniProt Comments for CSF3    Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Subunit structure: Monomer.

Subcellular location: Secreted.

Post-translational modification: O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

Pharmaceutical use: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).

Sequence similarities: Belongs to the IL-6 superfamily.

Caution: Ref.5 misquotes the gene name as "CSF1".
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Product References and Citations for anti-CSF3 antibody

   1. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.20.
2. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24.
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 Research Articles on CSF3    1. potential biomarker to document the local pre-conception environment for assisted fertilization
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSF3 antibodyPathways associated with anti-CSF3 antibody
 Reference Product  PubMed Publications
 CSF3R antibody  >8 publications with CSF3 and CSF3R
 ELANE antibody  >1 publications with CSF3 and ELANE
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with anti-CSF3 antibodyOrgans/Tissues associated with anti-CSF3 antibody
 Disease Name  Pubmed Publications
 Hematologic Diseases Antibodies  >8 publications with CSF3 and Hematologic Diseases
 Leukemia Antibodies  >8 publications with CSF3 and Leukemia
 Inflammation Antibodies  >7 publications with CSF3 and Inflammation
 Neoplasms Antibodies  >5 publications with CSF3 and Neoplasms
 Immune System Diseases Antibodies  >5 publications with CSF3 and Immune System Diseases
 Leukemia, Myeloid Antibodies  >4 publications with CSF3 and Leukemia, Myeloid
 Necrosis Antibodies  >4 publications with CSF3 and Necrosis
 Bone Marrow Diseases Antibodies  >4 publications with CSF3 and Bone Marrow Diseases
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >3 publications with CSF3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Anemia Antibodies  >2 publications with CSF3 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with CSF3 and Skin
 Lung Antibodies  >2 publications with CSF3 and Lung
 Brain Antibodies  >1 publications with CSF3 and Brain
 Muscle Antibodies  >1 publications with CSF3 and Muscle
 Uterus Antibodies  >1 publications with CSF3 and Uterus
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