NP_004480.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,907 Da
NCBI Official Full Name
G protein pathway suppressor 2
NCBI Official Synonym Full Names
G protein pathway suppressor 2
NCBI Official Synonym Symbols
NCBI Protein Information
G protein pathway suppressor 2; GPS-2
UniProt Protein Name
G protein pathway suppressor 2
UniProt Synonym Gene Names
UniProt Entry Name
GPS2_HUMAN
NCBI Summary for GPS2
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
UniProt Comments for GPS2
GPS2: Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Protein type: Nuclear receptor co-regulator; G protein regulator, misc.; Transcription, coactivator/corepressor; Inhibitor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: nucleoplasm; transcriptional repressor complex
Molecular Function: protein binding; transcription corepressor activity; GTPase inhibitor activity
Biological Process: negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; cell cycle; inactivation of MAPK activity
Research Articles on GPS2
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Products associated with anti-GPS2 antibody
Pathways associated with anti-GPS2 antibody
Diseases associated with anti-GPS2 antibody
Organs/Tissues associated with anti-GPS2 antibody
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