NP_000393.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 59 kDa Predicted: 60 kDa
NCBI Official Full Name
glucose-6-phosphate 1-dehydrogenase isoform a
NCBI Official Synonym Full Names
glucose-6-phosphate dehydrogenase
NCBI Official Synonym Symbols
NCBI Protein Information
glucose-6-phosphate 1-dehydrogenase
UniProt Protein Name
Glucose-6-phosphate 1-dehydrogenase
UniProt Synonym Gene Names
NCBI Summary for G6PD
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for G6PD
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Research Articles on G6PD
Precautions
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Disclaimer
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Products associated with anti-G6PD antibody
Pathways associated with anti-G6PD antibody
Diseases associated with anti-G6PD antibody
Organs/Tissues associated with anti-G6PD antibody
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