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anti-GABRB2 antibody :: Mouse GABA A Receptor beta 2,3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608577 anti-GABRB2 antibody
Unit / Price
0.2 mg  /  $690 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABA A Receptor beta 2,3 (GABRB2), Monoclonal Antibody

 Also Known As   

GABA A Receptor beta 2,3

 Product Synonym Names    Anti -GABA A Receptor beta 2,3
 Product Gene Name   

anti-GABRB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (160715436..160975130, complement). Location: 5q34
 OMIM    600232
 3D Structure    ModBase 3D Structure for P47870
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    0.T.52
 Host    Mouse
 Species Reactivity    Bovine, Human, Rat
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 Specificity    Recognizes bovine GABAA Receptor b2 (55kD) and b3 (57kD) subunits. Species Crossreactivity: human and rat.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide.
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 Immunogen    Affinity-purified GABAA receptor isolated from bovine brain.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-GABRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GABRB2 antibody

   GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.
 Product Categories/Family for anti-GABRB2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-GABRB2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-GABRB2 antibody    Suitable for use in Immunohistochemistry, Western Blot and Immunoprecipitation.
Dilution: Western Blot: 0.5-2ug/ml detected the GABA A Receptor beta 2,3 subunits from 20ug of rat brain microsomal preparation. Rat brain microsomal preparation was resolved by electrophoresis, transferred to nitrocellulose and probed with G1016 (2ug/ml). Proteins were visualized using a IgG (HRP) GtxMo and ECL.
Immunoprecipitation: 4ug immunoprecipated the GABA A Receptor beta 2,3 subunits from 500ug of rat brain microsomal preparation. Due to interference of the IgG heavy chain, the immunoprecipitated GABA A reseptor complex was confirmed using G1015-06.
Immunohistochemistry: Detects GABA A Receptor beta 2,3 subunits in paraffin embedded and frozen rat brain sections fixed with 4% paraformaldehyde or 1% glutaraldehyde and permeabilized with Triton X-100.
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NCBI/Uniprot data below describe general gene information for GABRB2. It may not necessarily be applicable to this product.
 NCBI GI #    119581948
 NCBI GeneID    2561
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 UniProt Primary Accession #    P47870 [Other Products]
 UniProt Secondary Accession #    Q16323; Q4FZB2; A8K115; A8K1A0; D1LYT0; D1LYT1 [Other Products]
 UniProt Related Accession #    P47870 [Other Products]
 Molecular Weight    59,150 Da [Similar Products]
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 NCBI Official Full Name    gamma-aminobutyric acid (GABA) A receptor, beta 2, isoform CRA_b
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, beta 2
 NCBI Official Symbol    GABRB2 [Similar Products]
 NCBI Official Synonym Symbols   
MGC119386; MGC119388; MGC119389
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit beta-2; OTTHUMP00000160871; OTTHUMP00000160872; OTTHUMP00000224259; OTTHUMP00000224260; GABA(A) receptor subunit beta-2; gamma-aminobutyric acid A receptor beta 2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit beta-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit beta-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    GABRB2 [Similar Products]
 UniProt Entry Name    GBRB2_HUMAN
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 NCBI Summary for GABRB2    The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq]
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 UniProt Comments for GABRB2    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. Ref.3 Ref.7

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. [View classification]
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 Research Articles on GABRB2    1. beta2Asp163 and alpha1Arg120 form a state-dependent salt bridge, interacting when GABA is bound to the receptor but not when the receptor is in the unbound state.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GABRB2 antibodyDiseases associated with anti-GABRB2 antibody
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >21 publications with GABRB2 and Schizophrenia
 Seizures Antibodies  >10 publications with GABRB2 and Seizures
 Alcoholism Antibodies  >9 publications with GABRB2 and Alcoholism
 Epilepsy Antibodies  >9 publications with GABRB2 and Epilepsy
 Epilepsy, Absence Antibodies  >3 publications with GABRB2 and Epilepsy, Absence
 Ataxia Antibodies  >2 publications with GABRB2 and Ataxia
 Dyskinesia, Drug-Induced Antibodies  >1 publications with GABRB2 and Dyskinesia, Drug-Induced
 Acidosis Antibodies  >1 publications with GABRB2 and Acidosis
 Inflammation Antibodies  >1 publications with GABRB2 and Inflammation
 Death Antibodies  >1 publications with GABRB2 and Death
Organs/Tissues associated with anti-GABRB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >37 publications with GABRB2 and Brain
 Kidney Antibodies  >10 publications with GABRB2 and Kidney
 Muscle Antibodies  >2 publications with GABRB2 and Muscle
 Eye Antibodies  >2 publications with GABRB2 and Eye
 Intestine Antibodies  >2 publications with GABRB2 and Intestine
 Blood Antibodies  >1 publications with GABRB2 and Blood
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