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anti-GAS7 antibody :: Mouse anti-Human, Mouse GAS7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200146
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GAS7, Monoclonal Antibody

 Also Known As   

GAS7 antibody (clone AT4H8)

 Product Synonym Names    KIAA0394; Growth arrest-specific 7; isoform b Growth arrest specific 7; GAS 7; GAS7; MGC1348; MLL/GAS7 fusion protein
 Product Gene Name   

anti-GAS7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    AT4H8
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Clone    Anti-human GAS7 mAb, clone AT4H8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human GAS7 protein.
 Immunogen    Recombinant human GAS7 (1-416aa) purified from E Coli
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 Preparation and Storage    Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-GAS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GAS7 antibody

   Growth arrest-specific 7, also known as GAS7, is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebellum impedes neurite outgrowth. Conversely, the hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcoma.
 Product Categories/Family for anti-GAS7 antibody    Neuroscience
 Applications Tested/Suitable for anti-GAS7 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GAS7 antibody    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1000. Recommended starting dilution is 1:500.
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 Western Blot (WB) of anti-GAS7 antibody    The extracts of mouse brain (50ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human GAS7 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-GAS7 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GAS7. It may not necessarily be applicable to this product.
 NCBI GI #    41406078
 NCBI GeneID    8522
 NCBI Accession #    NP_958836 [Other Products]
 NCBI GenBank Nucleotide #    NM_201432.1 [Other Products]
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 UniProt Secondary Accession #    O43144; Q53Y77; Q7Z571; A8KAC2; B2RCK9 [Other Products]
 UniProt Related Accession #    O60861 [Other Products]
 Molecular Weight    47,680 Da
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 NCBI Official Full Name    growth arrest-specific protein 7 isoform b
 NCBI Official Synonym Full Names    growth arrest-specific 7
 NCBI Official Symbol    GAS7 [Similar Products]
 NCBI Official Synonym Symbols   
MLL/GAS7
[Similar Products]
 NCBI Protein Information    growth arrest-specific protein 7; MLL/GAS7 fusion protein
 UniProt Protein Name    Growth arrest-specific protein 7
 Protein Family    Growth arrest-specific protein
 UniProt Gene Name    GAS7 [Similar Products]
 UniProt Synonym Gene Names    KIAA0394; GAS-7 [Similar Products]
 UniProt Entry Name    GAS7_HUMAN
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 NCBI Summary for GAS7    Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GAS7    GAS7: May play a role in promoting maturation and morphological differentiation of cerebellar neurons. A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with MLL/HRX. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Actin-binding; Oncoprotein; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: ruffle; cytoplasm; actin filament

Molecular Function: actin filament binding; transcription factor activity

Biological Process: actin filament bundle formation; regulation of cell shape; regulation of transcription, DNA-dependent; actin filament polymerization; cell cycle arrest; neurite morphogenesis
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Product References and Citations for anti-GAS7 antibody

   Chao CC, et al., (2005) J Neurosci Res. 81(2):153-62 She BR, et al., (2002) Exp Cell Res. 273(1):34-44
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 Research Articles on GAS7    1. We conclude that lower neuronal Gas7b levels may impact Alzheimer disease progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GAS7 antibodyDiseases associated with anti-GAS7 antibody
 Reference Product  PubMed Publications
 MYOC antibody  >4 publications with GAS7 and MYOC
 GPX3 antibody  >1 publications with GAS7 and GPX3
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >7 publications with GAS7 and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with GAS7 and Nervous System Diseases
 Carcinoma Antibodies  >3 publications with GAS7 and Carcinoma
 Lung Neoplasms Antibodies  >2 publications with GAS7 and Lung Neoplasms
 Disease Models, Animal Antibodies  >2 publications with GAS7 and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >2 publications with GAS7 and Carcinoma, Squamous Cell
 Thrombocytopenia Antibodies  >1 publications with GAS7 and Thrombocytopenia
 Skin Diseases Antibodies  >1 publications with GAS7 and Skin Diseases
 Anemia Antibodies  >1 publications with GAS7 and Anemia
 Liver Diseases Antibodies  >1 publications with GAS7 and Liver Diseases
Organs/Tissues associated with anti-GAS7 antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >30 publications with GAS7 and Nerve
 Brain Antibodies  >12 publications with GAS7 and Brain
 Eye Antibodies  >7 publications with GAS7 and Eye
 Blood Antibodies  >6 publications with GAS7 and Blood
 Bone Antibodies  >4 publications with GAS7 and Bone
 Ear Antibodies  >3 publications with GAS7 and Ear
 Embryonic Tissue Antibodies  >3 publications with GAS7 and Embryonic Tissue
 Lung Antibodies  >2 publications with GAS7 and Lung
 Muscle Antibodies  >2 publications with GAS7 and Muscle
 Prostate Antibodies  >1 publications with GAS7 and Prostate
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