NP_005248
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,386 Da
NCBI Official Full Name
transcription factor GATA-6
NCBI Official Synonym Full Names
GATA binding protein 6
NCBI Protein Information
transcription factor GATA-6
UniProt Protein Name
Transcription factor GATA-6
UniProt Synonym Protein Names
GATA-binding factor 6
UniProt Entry Name
GATA6_HUMAN
NCBI Summary for GATA6
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
UniProt Comments for GATA6
GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.1-q11.2
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; protein kinase binding; transcription factor binding; transcription factor activity
Biological Process: response to drug; cardiac muscle hypertrophy; transcription from RNA polymerase II promoter; endodermal cell fate determination; organ formation; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; tube morphogenesis; blood coagulation; positive regulation of cardiac muscle cell proliferation; negative regulation of apoptosis
Disease: Conotruncal Heart Malformations; Atrial Septal Defect 9; Heart Defects, Congenital, And Other Congenital Anomalies; Atrioventricular Septal Defect 5; Tetralogy Of Fallot
Research Articles on GATA6
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Products associated with anti-GATA6 antibody
Pathways associated with anti-GATA6 antibody
Diseases associated with anti-GATA6 antibody
Organs/Tissues associated with anti-GATA6 antibody
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