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anti-GCN5L2 antibody :: Mouse anti-Human GCN5L2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120468
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GCN5L2, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human GCN5L2

 Product Synonym Names    Homo sapiens GCN5 general control of amino-acid synthesis 5-like 2 (yeast) (GCN5L2), mRNA.; GCN5; hGCN5; PCAF-b; MGC102791
 Product Gene Name   

anti-GCN5L2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602301
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2384C5_2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-GCN5L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GCN5L2 antibody

   Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.[UniProtKB Function]
 Applications Tested/Suitable for anti-GCN5L2 antibody   

Dot Blot (DB)

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 Quality Control of anti-GCN5L2 antibody    Western blot analysis of immunized recombinant protein, using anti-GCN5L2 monoclonal antibody.
anti-GCN5L2 antibody Quality Control image
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 Quality Control #2 of anti-GCN5L2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-GCN5L2 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for GCN5L2. It may not necessarily be applicable to this product.
 NCBI GI #    153791534
 NCBI GeneID    2648
 NCBI Accession #    NP_066564.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021078 [Other Products]
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 UniProt Secondary Accession #    Q8N1A2; Q9UCW1 [Other Products]
 UniProt Related Accession #    Q92830 [Other Products]
 Molecular Weight    48,921 Da
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 NCBI Official Full Name    Homo sapiens K(lysine) acetyltransferase 2A (KAT2A), mRNA
 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 2A
 NCBI Official Symbol    KAT2A [Similar Products]
 NCBI Official Synonym Symbols   
GCN5; hGCN5; GCN5L2; PCAF-b
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; STAF97; general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; lysine acetyltransferase 2A
 UniProt Protein Name    Histone acetyltransferase KAT2A
 UniProt Synonym Protein Names   
General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
 UniProt Gene Name    KAT2A [Similar Products]
 UniProt Entry Name    KAT2A_HUMAN
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 NCBI Summary for GCN5L2    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
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 UniProt Comments for GCN5L2    GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.

Protein type: Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; extracellular space

Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; somitogenesis; viral reproduction; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; cell proliferation; telencephalon development; neural tube closure; midbrain development
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 Research Articles on GCN5L2    1. Purified GCN5 binds to an N-terminal sub-domain of MYC TAD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GCN5L2 antibodyPathways associated with anti-GCN5L2 antibody
 Reference Product  PubMed Publications
 MYC antibody  >8 publications with GCN5L2 and MYC
 TRRAP antibody  >7 publications with GCN5L2 and TRRAP
 TADA2A antibody  >3 publications with GCN5L2 and TADA2A
 TAF4 antibody  >2 publications with GCN5L2 and TAF4
 TAF10 antibody  >2 publications with GCN5L2 and TAF10
 SUPT3H antibody  >1 publications with GCN5L2 and SUPT3H
 Products by Pathway  Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
Diseases associated with anti-GCN5L2 antibodyOrgans/Tissues associated with anti-GCN5L2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with GCN5L2 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with GCN5L2 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with GCN5L2 and Kidney Diseases
 Brain Diseases Antibodies  >2 publications with GCN5L2 and Brain Diseases
 Body Weight Changes Antibodies  >1 publications with GCN5L2 and Body Weight Changes
 Nerve Degeneration Antibodies  >1 publications with GCN5L2 and Nerve Degeneration
 Fatty Liver Antibodies  >1 publications with GCN5L2 and Fatty Liver
 Fibrosis Antibodies  >1 publications with GCN5L2 and Fibrosis
 Ovarian Diseases Antibodies  >1 publications with GCN5L2 and Ovarian Diseases
 Musculoskeletal Abnormalities Antibodies  >1 publications with GCN5L2 and Musculoskeletal Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with GCN5L2 and Liver
 Blood Antibodies  >3 publications with GCN5L2 and Blood
 Lung Antibodies  >3 publications with GCN5L2 and Lung
 Muscle Antibodies  >2 publications with GCN5L2 and Muscle
 Kidney Antibodies  >2 publications with GCN5L2 and Kidney
 Nerve Antibodies  >2 publications with GCN5L2 and Nerve
 Brain Antibodies  >2 publications with GCN5L2 and Brain
 Bone Antibodies  >1 publications with GCN5L2 and Bone
 Eye Antibodies  >1 publications with GCN5L2 and Eye
 Intestine Antibodies  >1 publications with GCN5L2 and Intestine
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