NP_033426.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,334 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 18 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 18
NCBI Official Synonym Symbols
NCBI Protein Information
tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 18
UniProt Synonym Protein Names
Glucocorticoid-induced TNFR-related protein
UniProt Synonym Gene Names
UniProt Entry Name
TNR18_MOUSE
UniProt Comments for GITR
Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway
By similarity.
Subunit structure: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6
By similarity. Binds through its C-terminus to SIVA1/SIVA. Ref.5
Subcellular location: Isoform A: Cell membrane; Single-pass type I membrane protein. Isoform B: Cell membrane; Single-pass type I membrane protein. Isoform C: Cell membrane; Single-pass type I membrane protein. Isoform D: Secreted.
Tissue specificity: Preferentially expressed in activated T lymphocytes.
Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
Sequence similarities: Contains 3 TNFR-Cys repeats.
Research Articles on GITR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-GITR antibody
Diseases associated with anti-GITR antibody
Organs/Tissues associated with anti-GITR antibody
|