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anti-GRK2 antibody :: Mouse GRK2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850581
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRK2, Monoclonal Antibody

 Also Known As   

GRK2 Antibody

 Product Synonym Names    GRK2; BARK1; FLJ16718; BETA-ARK1; ADRBK1
 Product Gene Name   

anti-GRK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109635
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 Clonality    Monoclonal
 Clone Number    3F8
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human GRK2 expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-GRK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GRK2 antibody

   Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes
 Product Categories/Family for anti-GRK2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GRK2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-GRK2 antibody    WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-GRK2 antibody    Figure 1: Western blot analysis using GRK2 mouse mAb against Hela (1), Jurkat (2), MOLT4 (3), RAJI (4), THP-1 (5), L1210 (6), Cos7 (7), PC-12 (8), and NIH/3T3 (9) cell lysate.
anti-GRK2 antibody Testing Data image
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 Testing Data #2 of anti-GRK2 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues (left) and cervical cancer tissues (right) using GRK2 mouse mAb with DAB staining.
anti-GRK2 antibody Testing Data #2 image
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 Testing Data #3 of anti-GRK2 antibody    anti-GRK2 antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for GRK2. It may not necessarily be applicable to this product.
 NCBI GI #    148539876
 NCBI GeneID    156
 NCBI Accession #    NP_001610.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001619.3 [Other Products]
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 UniProt Secondary Accession #    Q13837; Q6GTT3; B0ZBE1 [Other Products]
 UniProt Related Accession #    P25098 [Other Products]
 Molecular Weight    80kDa
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 NCBI Official Full Name    beta-adrenergic receptor kinase 1
 NCBI Official Synonym Full Names    adrenergic, beta, receptor kinase 1
 NCBI Official Symbol    ADRBK1 [Similar Products]
 NCBI Official Synonym Symbols   
GRK2; BARK1; BETA-ARK1
[Similar Products]
 NCBI Protein Information    beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein coupled receptor kinase 2
 UniProt Protein Name    Beta-adrenergic receptor kinase 1
 UniProt Synonym Protein Names   
G-protein coupled receptor kinase 2
 Protein Family    Beta-adrenergic receptor kinase
 UniProt Gene Name    ADRBK1 [Similar Products]
 UniProt Synonym Gene Names    BARK; BARK1; GRK2; Beta-ARK-1 [Similar Products]
 UniProt Entry Name    ARBK1_HUMAN
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 NCBI Summary for GRK2    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRK2    GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function.

Protein type: Protein kinase, AGC; EC 2.7.11.15; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor kinase activity; protein binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; tachykinin signaling pathway; fibroblast growth factor receptor signaling pathway; acetylcholine receptor signaling, muscarinic pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; positive regulation of catecholamine secretion; innate immune response; cardiac muscle contraction
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 Research Articles on GRK2    1. GRK2 is localized to centrosomes and plays a central role in mitogen-promoted centrosome separation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRK2 antibodyPathways associated with anti-GRK2 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >57 publications with GRK2 and ADRB2
 RHO antibody  >11 publications with GRK2 and RHO
 GIT1 antibody  >9 publications with GRK2 and GIT1
 CXCR4 antibody  >6 publications with GRK2 and CXCR4
 CCR5 antibody  >2 publications with GRK2 and CCR5
 BDKRB2 antibody  >1 publications with GRK2 and BDKRB2
 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-GRK2 antibodyOrgans/Tissues associated with anti-GRK2 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >99 publications with GRK2 and Heart Diseases
 Inflammation Antibodies  >54 publications with GRK2 and Inflammation
 Hypertension Antibodies  >44 publications with GRK2 and Hypertension
 Myocardial Ischemia Antibodies  >35 publications with GRK2 and Myocardial Ischemia
 Pain Antibodies  >27 publications with GRK2 and Pain
 Myocardial Infarction Antibodies  >27 publications with GRK2 and Myocardial Infarction
 Cardiomegaly Antibodies  >16 publications with GRK2 and Cardiomegaly
 Cardiomyopathies Antibodies  >14 publications with GRK2 and Cardiomyopathies
 Postoperative Complications Antibodies  >13 publications with GRK2 and Postoperative Complications
 Necrosis Antibodies  >12 publications with GRK2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >123 publications with GRK2 and Muscle
 Blood Antibodies  >112 publications with GRK2 and Blood
 Brain Antibodies  >98 publications with GRK2 and Brain
 Kidney Antibodies  >66 publications with GRK2 and Kidney
 Vascular Antibodies  >66 publications with GRK2 and Vascular
 Nerve Antibodies  >24 publications with GRK2 and Nerve
 Lung Antibodies  >15 publications with GRK2 and Lung
 Bone Antibodies  >15 publications with GRK2 and Bone
 Liver Antibodies  >14 publications with GRK2 and Liver
 Embryonic Tissue Antibodies  >13 publications with GRK2 and Embryonic Tissue
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