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anti-HSPA9 antibody :: Mouse GRP75 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS802337
Testing Data
Unit / Price
0.1 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRP75 (HSPA9), Monoclonal Antibody

 Also Known As   

Grp75 Antibody: ATTO 633

 Product Synonym Names    Hsc74; Hsp74; HspA9; Hspa9a; HspA9B; Mortalin 2; MOT2; PBP74
 Product Gene Name   

anti-HSPA9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600548
 3D Structure    ModBase 3D Structure for P38646
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    S52A-42
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Protein G Purified
 Concentration    1mg/mL (lot specific)
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 Conjugate    ATTO 633
 Storage Buffer    PBS pH7.2, 50% glycerol, 0.09% sodium azide
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-HSPA9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HSPA9 antibody

   Background Info: Detects ~75kDa.

Scientific Background: Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible (1, 2). Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle (3, 4). Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 (5). Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (6). Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts (7). And finally, like its E.coli homolog DnaK (8), GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10).
 Product Categories/Family for anti-HSPA9 antibody    Chaperones, Heat Shock, Organelle Markers
 Applications Tested/Suitable for anti-HSPA9 antibody   

Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)

 Application Notes for anti-HSPA9 antibody    1:1000 (colorimetric) (WB)
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 Testing Data of anti-HSPA9 antibody    Western blot analysis of Grp75 in HeLa cell lysates using a 1:1000 dilution .
anti-HSPA9 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for HSPA9. It may not necessarily be applicable to this product.
 NCBI GI #    24234688
 NCBI GeneID    3313
 NCBI Accession #    NP_004125.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004134.6 [Other Products]
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 UniProt Primary Accession #    P38646 [Other Products]
 UniProt Secondary Accession #    P30036; P31932; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56; B2RCM1 [Other Products]
 UniProt Related Accession #    P38646 [Other Products]
 Molecular Weight    73,680 Da [Similar Products]
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 NCBI Official Full Name    stress-70 protein, mitochondrial
 NCBI Official Synonym Full Names    heat shock 70kDa protein 9 (mortalin)
 NCBI Official Symbol    HSPA9 [Similar Products]
 NCBI Official Synonym Symbols   
CSA; MOT; MOT2; CRP40; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m
[Similar Products]
 NCBI Protein Information    stress-70 protein, mitochondrial; mortalin-2; p66-mortalin; mortalin, perinuclear; heat shock 70kD protein 9B; peptide-binding protein 74; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m
 UniProt Protein Name    Stress-70 protein, mitochondrial
 UniProt Synonym Protein Names   
75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74
 Protein Family    Stress-70 protein
 UniProt Gene Name    HSPA9 [Similar Products]
 UniProt Synonym Gene Names    GRP75; HSPA9B; mt-HSP70; GRP-75; MOT; PBP74 [Similar Products]
 UniProt Entry Name    GRP75_HUMAN
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 NCBI Summary for HSPA9    This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
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 UniProt Comments for HSPA9    HSPA9B: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Nucleolus; Heat shock protein

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: focal adhesion; mitochondrion; cytoplasm; nucleolus

Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding

Biological Process: cellular protein metabolic process; protein folding; protein export from nucleus; protein targeting to mitochondrion; negative regulation of apoptosis
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Product References and Citations for anti-HSPA9 antibody

   1. Kaul S.C., et al. (1993) Biochem Biophys Res Commun. 193: 348-355. 2. Wadhwa R., et al. (1993) J Biol Chem 268: 6615-6621. 3. Schneider H.C., et al. (1994) Nature 371: 768-774. 4. Manning-Krieg U.C., et al. (1991) EMBO J. 10: 3273-3280. 5. Wadhwa R., et al. (1998) J Biol Chem. 273: 29586-91. 6. Wadhwa R., et al. (2006) Int J Cancer 118: 2973-2980. 7. Kaul S.C., et al. (2003) Exp Cell Res. 286: 96-110. 8. Liberek K., et al. (1991) J Biol Chem. 266: 14491-14496. 9. Mizzen L.A., et al. (1991) Cell Regulation. 2: 165-179. 10. Leustek U.K., et al. (1989) PNAS USA. 86: 7805-7808.
1. Rozenberg, P., Kocsis, J., Saar, M., Prohszka, Z., Fst, G., and Fishelson, Z. (2013). Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in colorectal cancer patients. Int J Cancer. 133 (2), 514-518. doi: 10.1002/ijc.28029
2. Saar Ray, M., Moskovich, O., Iosefson, O., Fishelson Z. (2014). Mortalin/Grp75 Binds to Complement C9 and Plays a Role in Resistance to Complement-Dependent Cytotoxicity. J Biol Chem. doi: 10.1074/jbc.M114.552406
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 Research Articles on HSPA9    1. CRP40 is genetically dysregulated in Parkinson disease and presents a significant opportunity for further investigation of molecular chaperone proteins as biomarkers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HSPA9 antibodyDiseases associated with anti-HSPA9 antibody
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >10 publications with HSPA9 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >7 publications with HSPA9 and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with HSPA9 and Nervous System Diseases
 Immune System Diseases Antibodies  >5 publications with HSPA9 and Immune System Diseases
 Parkinson Disease Antibodies  >4 publications with HSPA9 and Parkinson Disease
 Cardiovascular Diseases Antibodies  >3 publications with HSPA9 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with HSPA9 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with HSPA9 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with HSPA9 and Liver Neoplasms
 Lung Neoplasms Antibodies  >1 publications with HSPA9 and Lung Neoplasms
Organs/Tissues associated with anti-HSPA9 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HSPA9 and Blood
 Liver Antibodies  >7 publications with HSPA9 and Liver
 Brain Antibodies  >7 publications with HSPA9 and Brain
 Lung Antibodies  >5 publications with HSPA9 and Lung
 Bone Antibodies  >5 publications with HSPA9 and Bone
 Skin Antibodies  >4 publications with HSPA9 and Skin
 Bone Marrow Antibodies  >3 publications with HSPA9 and Bone Marrow
 Mouth Antibodies  >2 publications with HSPA9 and Mouth
 Muscle Antibodies  >2 publications with HSPA9 and Muscle
 Connective Tissue Antibodies  >2 publications with HSPA9 and Connective Tissue
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