Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow GSK3B rightarrow Monoclonal GSK3B  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • v-Myb Myeloblastosis Viral Oncogene Homolog (MYBL2) Antibody
 • Soytone Culture Media
 • Follicle-Stimulating Hormone (FSH) ELISA Kit
 • Tumor necrosis factor receptor superfamily member 6 (FAS) Antibody
 • Pseudomonas aeruginosa Exotoxin A Antibody
 • Threonyl t-RNA Synthetase (PL 7) Recombinant Protein
 • shroom family member 3 (SHROOM3) ELISA Kit
 • Akt (Akt1) Antibody
 • CD4 Antibody
 • Tn-T ELISA Kit
 • ras-related C3 botulinum toxin substrate 1 (rho family, smal... ELISA Kit
 • fFN Antibody
 • CLDN3 (Claudin 3) ELISA Kit
 • Angiopoietin Like Protein 4 (ANGPTL4) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-GSK3B antibody :: Mouse anti-Human GSK-3 beta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS670122 anti-GSK3B antibody
Unit / Price
50 Tests  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK-3 beta (GSK3B), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human GSK-3b-SEPH

 Product Synonym Names    Mouse Anti-Human GSK-3b - Sepharose-Labeled; Mouse Anti-Human GSK-3 beta
 Product Gene Name   

anti-GSK3B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 3; NC_000003.11 (119540800..119813264, complement). Location: 3q13.3
 OMIM    605004
 3D Structure    ModBase 3D Structure for P49841
Section Bar
 Clonality    Monoclonal
 Isotype    Mouse IgG2b
 Clone Number    5D6
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    Human GSK-3 beta
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 alpha and GSK-3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
 Form/Format    Sepharose 4B (SEPH) Conjugate
Section Bar
 Characterization    To insure lot-to-lot consistency, each batch of product is tested by western blotting to conform with the characteristics of a standard reference reagent.
Section Bar
 Preparation and Storage    The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The Sepharose 4B (SEPH) conjugate is supplied as 50 tests in 2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C. Shake well before use.
Reagents are stable for the period shown on the label if stored as directed.
 Other Notes    Small volumes of anti-GSK3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-GSK3B antibody   

ELISA; Immunoprecipitation; Western Blot

 Application Notes for anti-GSK3B antibody    Immunoprecipitation Suggested Dilution: 40uL
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for GSK3B. It may not necessarily be applicable to this product.
 NCBI GI #    225903437
 NCBI GeneID    2932
 NCBI Accession #    NP_001139628.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001146156.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P49841 [Other Products]
 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841; Q6FI27 [Other Products]
 Molecular Weight    46,744 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    glycogen synthase kinase-3 beta isoform 2
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Official Synonym Symbols   
GSK3B
[Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; OTTHUMP00000165239; OTTHUMP00000165240
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 Protein Family    Glycogen synthase kinase
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Entry Name    GSK3B_HUMAN
Section Bar
 NCBI Summary for GSK3B    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Section Bar
 UniProt Comments for GSK3B    Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. May be required for early embryo development and neuron differentiation

By similarity. Ref.7 Ref.11 Ref.30 Ref.34

Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate.

Enzyme regulation: Activated by phosphorylation at Tyr-216. Inhibited when phosphorylated by AKT1. Ref.34

Subunit structure: Monomer

By similarity. Interacts with ARRB2 and DISC1

By similarity. Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylates of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B

By similarity. Ref.6 Ref.7 Ref.9 Ref.10 Ref.11 Ref.13 Ref.18 Ref.20 Ref.27 Ref.34

Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. Ref.11 Ref.30

Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.

Post-translational modification: Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216. Ref.9 Ref.12 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.28 Ref.29 Ref.30 Ref.34

Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain.
Table BarTOPTable Bar
 Research Articles on GSK3B    1. The haplotype analysis of this study revealed that, the T-T haplotype of both GSK3beta polymorphisms was over-represented in parkinson disease patients compared to controls, and this association was independent of MAPT H1 haplotype.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-GSK3B antibodyPathways associated with anti-GSK3B antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >18 publications with GSK3B and CTNNB1
 AKT1 antibody  >8 publications with GSK3B and AKT1
 MAPT antibody  >7 publications with GSK3B and MAPT
 APP antibody  >5 publications with GSK3B and APP
 APC antibody  >4 publications with GSK3B and APC
 MYC antibody  >4 publications with GSK3B and MYC
 AXIN1 antibody  >3 publications with GSK3B and AXIN1
 PSEN1 antibody  >3 publications with GSK3B and PSEN1
 AXIN2 antibody  >2 publications with GSK3B and AXIN2
 AKT2 antibody  >2 publications with GSK3B and AKT2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-GSK3B antibodyOrgans/Tissues associated with anti-GSK3B antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >18 publications with GSK3B and Mental Disorders
 Neurodegenerative Diseases Antibodies  >11 publications with GSK3B and Neurodegenerative Diseases
 Neoplasms Antibodies  >11 publications with GSK3B and Neoplasms
 Dementia Antibodies  >9 publications with GSK3B and Dementia
 Alzheimer Disease Antibodies  >8 publications with GSK3B and Alzheimer Disease
 Bipolar Disorder Antibodies  >7 publications with GSK3B and Bipolar Disorder
 Insulin Resistance Antibodies  >7 publications with GSK3B and Insulin Resistance
 Mood Disorders Antibodies  >6 publications with GSK3B and Mood Disorders
 Metabolic Diseases Antibodies  >6 publications with GSK3B and Metabolic Diseases
 Depressive Disorder Antibodies  >5 publications with GSK3B and Depressive Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with GSK3B and Brain
 Blood Antibodies  >10 publications with GSK3B and Blood
 Ovary Antibodies  >8 publications with GSK3B and Ovary
 Muscle Antibodies  >4 publications with GSK3B and Muscle
 Bone Antibodies  >3 publications with GSK3B and Bone
 Heart Antibodies  >3 publications with GSK3B and Heart
 Liver Antibodies  >3 publications with GSK3B and Liver
 Uterus Antibodies  >2 publications with GSK3B and Uterus
 Pancreas Antibodies  >2 publications with GSK3B and Pancreas
 Connective Tissue Antibodies  >2 publications with GSK3B and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions