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anti-GSK3B antibody :: Mouse GSK3B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831019
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK3B, Monoclonal Antibody

 Also Known As   

GSK3B antibody

 Product Synonym Names    Monoclonal GSK3B; Anti-GSK3B; GSK3B; GSKB-3; GSK3 beta; GSKB 3; Glycogen synthase kinase 3 beta
 Product Gene Name   

anti-GSK3B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605004
 3D Structure    ModBase 3D Structure for P49841
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    3D10
 Host    Mouse
 Species Reactivity    Human, Rat, Mouse, Monkey
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Glycogen synthase kinase 3 beta is a serine/threonine kinase involved in insulin, growth factor and Wnt signaling. Glycogen synthase kinase 3 beta (GSk3beta) is a molecular regulator of cell fate in the central nervous system and a target of the phosphatidylinositol 3-kinase (PI3k) pathway. It is an enzyme with a diverse number of actions in intracellular signaling systems, regulating neuronal plasticity, gene expression and cell survival.
 Immunogen    GSK3B antibody was raised in Mouse using a purified recombinant fragment of human GSK3B expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-GSK3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GSK3B antibody

   Mouse monoclonal GSK3B antibody
 Product Categories/Family for anti-GSK3B antibody    Signal Transduction
 Applications Tested/Suitable for anti-GSK3B antibody   

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-GSK3B antibody    ELISA: 1:10,000
IF: 1:200-1:1000
IHC: 1:200-1:1000
WB: 1:500-1:2000
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 Western Blot (WB) of anti-GSK3B antibody    Western Blot showing GSK3B antibody used against A549 (1), K562 (2), PC-12 (3), NIH/3T3 (4), and HEK293 (5) cell lysate.
anti-GSK3B antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GSK3B antibody    Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and breast cancer tissues (right) using GSK3B antibody with DAB staining.
anti-GSK3B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-GSK3B antibody    Immunofluorescence analysis of NIH/3T3 (left) and U251 (right) cells using GSK3B antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-GSK3B antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GSK3B. It may not necessarily be applicable to this product.
 NCBI GI #    225903437
 NCBI GeneID    2932
 NCBI Accession #    NP_001139628.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001146156.1 [Other Products]
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 UniProt Primary Accession #    P49841 [Other Products]
 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841 [Other Products]
 Molecular Weight    48,034 Da
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 NCBI Official Full Name    glycogen synthase kinase-3 beta isoform 2
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 UniProt Synonym Protein Names   
Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
 Protein Family    Glycogen synthase kinase
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Synonym Gene Names    GSK-3 beta [Similar Products]
 UniProt Entry Name    GSK3B_HUMAN
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 NCBI Summary for GSK3B    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for GSK3B    GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: EC 2.7.11.1; EC 2.7.11.26; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: centrosome; dendritic spine; cytosol; ribonucleoprotein complex; beta-catenin destruction complex; lipid raft; nucleoplasm; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus

Molecular Function: integrin binding; ionotropic glutamate receptor binding; NF-kappaB binding; protein serine/threonine kinase activity; protein binding; p53 binding; ubiquitin protein ligase binding; tau-protein kinase activity; beta-catenin binding; kinase activity; protein kinase binding; tau protein binding; ATP binding

Biological Process: glycogen metabolic process; fat cell differentiation; circadian rhythm; negative regulation of MAP kinase activity; axon guidance; re-entry into mitotic cell cycle; genetic imprinting; nerve growth factor receptor signaling pathway; positive regulation of protein binding; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; positive regulation of cell-matrix adhesion; negative regulation of protein binding; myoblast fusion; ER overload response; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; response to drug; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of neuron maturation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; regulation of neuronal synaptic plasticity; negative regulation of apoptosis
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 Research Articles on GSK3B    1. Results indicate that the SNPs in the selected regions of the GSK3b gene (rs3732361, rs56728675, rs60393216, and rs334558) did not confer the susceptibility of sporadic Alzheimer's disease in a cohort of southern Han Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSK3B antibodyPathways associated with anti-GSK3B antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >30 publications with GSK3B and CTNNB1
 JUN antibody  >18 publications with GSK3B and JUN
 MAPT antibody  >13 publications with GSK3B and MAPT
 AKT1 antibody  >9 publications with GSK3B and AKT1
 MYC antibody  >7 publications with GSK3B and MYC
 APC antibody  >4 publications with GSK3B and APC
 AXIN1 antibody  >4 publications with GSK3B and AXIN1
 FRAT1 antibody  >2 publications with GSK3B and FRAT1
 AXIN2 antibody  >2 publications with GSK3B and AXIN2
 LRP6 antibody  >1 publications with GSK3B and LRP6
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with anti-GSK3B antibodyOrgans/Tissues associated with anti-GSK3B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with GSK3B and Nervous System Diseases
 Brain Diseases Antibodies  >25 publications with GSK3B and Brain Diseases
 Bipolar Disorder Antibodies  >16 publications with GSK3B and Bipolar Disorder
 Alzheimer Disease Antibodies  >16 publications with GSK3B and Alzheimer Disease
 Schizophrenia Antibodies  >13 publications with GSK3B and Schizophrenia
 Disease Models, Animal Antibodies  >13 publications with GSK3B and Disease Models, Animal
 Depressive Disorder Antibodies  >11 publications with GSK3B and Depressive Disorder
 Movement Disorders Antibodies  >9 publications with GSK3B and Movement Disorders
 Cardiovascular Diseases Antibodies  >8 publications with GSK3B and Cardiovascular Diseases
 Heart Diseases Antibodies  >6 publications with GSK3B and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with GSK3B and Brain
 Blood Antibodies  >22 publications with GSK3B and Blood
 Muscle Antibodies  >12 publications with GSK3B and Muscle
 Ovary Antibodies  >11 publications with GSK3B and Ovary
 Liver Antibodies  >9 publications with GSK3B and Liver
 Bone Antibodies  >8 publications with GSK3B and Bone
 Heart Antibodies  >6 publications with GSK3B and Heart
 Lung Antibodies  >5 publications with GSK3B and Lung
 Embryonic Tissue Antibodies  >5 publications with GSK3B and Embryonic Tissue
 Connective Tissue Antibodies  >4 publications with GSK3B and Connective Tissue
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