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anti-GSK3B antibody :: Mouse anti-Human GSK3B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850487
Testing Data
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK3B, Monoclonal Antibody

 Also Known As   

GSK3B Antibody

 Product Gene Name   

anti-GSK3B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605004
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Other Notes    Small volumes of anti-GSK3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GSK3B antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GSK3B antibody   

ELISA (EIA), Western Blot (WB)

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 Testing Data of anti-GSK3B antibody    GSK3B (C-terminus) antibody at 1/1000 dilution + Hela whole cell lysate 40ug/Lane. Predicted band size: 47KDa. Observed band size: 47KDa.
anti-GSK3B antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GSK3B. It may not necessarily be applicable to this product.
 NCBI GI #    225903437
 NCBI GeneID    2932
 NCBI Accession #    NP_001139628.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002093.2 [Other Products]
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 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841 [Other Products]
 Molecular Weight    48,034 Da
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 NCBI Official Full Name    glycogen synthase kinase-3 beta isoform 2
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 UniProt Synonym Protein Names   
Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
 Protein Family    Glycogen synthase kinase
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Synonym Gene Names    GSK-3 beta [Similar Products]
 UniProt Entry Name    GSK3B_HUMAN
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 NCBI Summary for GSK3B    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for GSK3B    GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: centrosome; dendritic spine; beta-catenin destruction complex; cytosol; ribonucleoprotein complex; lipid raft; nucleoplasm; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus

Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; integrin binding; ionotropic glutamate receptor binding; NF-kappaB binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding

Biological Process: glycogen metabolic process; fat cell differentiation; circadian rhythm; axon guidance; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; nerve growth factor receptor signaling pathway; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; response to drug; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; organ morphogenesis; peptidyl-serine phosphorylation; negative regulation of neuron maturation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity
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 Research Articles on GSK3B    1. Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSK3B antibodyPathways associated with anti-GSK3B antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >27 publications with GSK3B and CTNNB1
 MAPT antibody  >12 publications with GSK3B and MAPT
 AKT1 antibody  >9 publications with GSK3B and AKT1
 MYC antibody  >6 publications with GSK3B and MYC
 AXIN1 antibody  >4 publications with GSK3B and AXIN1
 TP53 antibody  >2 publications with GSK3B and TP53
 AXIN2 antibody  >2 publications with GSK3B and AXIN2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
Diseases associated with anti-GSK3B antibodyOrgans/Tissues associated with anti-GSK3B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with GSK3B and Nervous System Diseases
 Brain Diseases Antibodies  >24 publications with GSK3B and Brain Diseases
 Bipolar Disorder Antibodies  >15 publications with GSK3B and Bipolar Disorder
 Alzheimer Disease Antibodies  >14 publications with GSK3B and Alzheimer Disease
 Disease Models, Animal Antibodies  >12 publications with GSK3B and Disease Models, Animal
 Schizophrenia Antibodies  >11 publications with GSK3B and Schizophrenia
 Depressive Disorder Antibodies  >10 publications with GSK3B and Depressive Disorder
 Movement Disorders Antibodies  >8 publications with GSK3B and Movement Disorders
 Cardiovascular Diseases Antibodies  >7 publications with GSK3B and Cardiovascular Diseases
 Inflammation Antibodies  >6 publications with GSK3B and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with GSK3B and Brain
 Blood Antibodies  >20 publications with GSK3B and Blood
 Muscle Antibodies  >12 publications with GSK3B and Muscle
 Ovary Antibodies  >11 publications with GSK3B and Ovary
 Liver Antibodies  >9 publications with GSK3B and Liver
 Bone Antibodies  >8 publications with GSK3B and Bone
 Heart Antibodies  >5 publications with GSK3B and Heart
 Lung Antibodies  >5 publications with GSK3B and Lung
 Connective Tissue Antibodies  >4 publications with GSK3B and Connective Tissue
 Embryonic Tissue Antibodies  >4 publications with GSK3B and Embryonic Tissue
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