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anti-LGALS3 antibody :: Mouse Galectin3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533328 anti-LGALS3 antibody
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 Product Name   

Galectin3 (LGALS3), Monoclonal Antibody

★Popular Item★
 Also Known As   

Galectin3 antibody

 Product Synonym Names    Monoclonal Galectin 3; Anti-Galectin 3; Galectin -3; CPB-35; IgE-binding; L-29; MAC2; Galectin 3; Galectin-3
 Product Gene Name   

anti-LGALS3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153619
 3D Structure    ModBase 3D Structure for P17931
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    38B2
 Host    Mouse
 Species Reactivity    To be determined by end-user.
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 Purity/Purification    Galectin 3 antibody was affinity purified with protein A
 Form/Format    Lyophilized product from 1% BSA in PBS, pH 7.4 containing 0.05% NaN3, reconstitute with 1 ml of distilled water
 Concentration    100ug lyophilized (lot specific)
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 Source Note    Supernatant
 Biological Significance    Galectin is widely distributed in nematodes, insects, and porifers, as well as vertebrates, and it has also been found to be present in true fungi. Galectin does not just occur in the cytoplasm, it is also present in the nucleus, on the cell surface, in the extracellular matrix, etc., and it is thought to be involved in many biological phenomena, including development, differentiation, morphogenesis, tumor metastasis, cell death, and RNA splicing. Galectin3 is a beta galactoside-binding protein that has been named IgE-binding protein, CBP35, CBP30, Mac2, L29, L31, L34, etc., and structurally it is a chimera-type lectin composed of a sugarchain-binding domain (galectin domain) and a nonlectin domain. Its biological function is still uncertain, but many studies that should elucidate its function have been performed, and as a result participation of galectin-3 has been demonstrated in the biological phenomena of cell growth, adhesion, metastasis, and apoptosis. For example, a positive correlation has been shown between galectin-3 expression and the degree of malignant transformation in certain types of cell lines. A positive correlation has also recently been shown between galectin-3 expression and degree of malignancy in certain types of malignant tumors, and measurement of galectin3 is expected to possibly serve as an index of degree of tumor malignancy.
 Immunogen    Galectin 3 antibody was raised in mouse using recombinant galectin3 protein as the immunogen
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 Preparation and Storage    Store lyophilized product at 4 degree C up to 5 years and solution at -20 degree C up to 2 years.
 Other Notes    Small volumes of anti-LGALS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LGALS3 antibody

   Human Galectin 3 antibody
 Product Categories/Family for anti-LGALS3 antibody    Nutrition & Metabolism
 Applications Tested/Suitable for anti-LGALS3 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-LGALS3 antibody    IHC: 25 ug/mL
WB: 25 ug/ml
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NCBI/Uniprot data below describe general gene information for LGALS3. It may not necessarily be applicable to this product.
 NCBI GI #    2385452
 NCBI GeneID    3958
 NCBI Accession #    BAA22164.1 [Other Products]
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 UniProt Primary Accession #    P17931 [Other Products]
 UniProt Secondary Accession #    Q16005; Q6IBA7; Q96J47; B2RC38 [Other Products]
 UniProt Related Accession #    P17931 [Other Products]
 Molecular Weight    26,152 Da [Similar Products]
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 NCBI Official Full Name    galectin-3
 NCBI Official Synonym Full Names    lectin, galactoside-binding, soluble, 3
 NCBI Official Symbol    LGALS3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    galectin-3
 UniProt Protein Name    Galectin-3
 UniProt Synonym Protein Names   
35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
 UniProt Gene Name    LGALS3 [Similar Products]
 UniProt Synonym Gene Names    MAC2; Gal-3; CBP 35; GALBP [Similar Products]
 UniProt Entry Name    LEG3_HUMAN
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 NCBI Summary for LGALS3    This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
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 UniProt Comments for LGALS3    Galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages.

Protein type: Extracellular matrix; Cell surface; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: extracellular matrix; spliceosome; extracellular space; proteinaceous extracellular matrix; membrane; cytoplasm; mitochondrial inner membrane; plasma membrane; immunological synapse; nucleus; external side of plasma membrane

Molecular Function: protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity

Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; RNA splicing; negative regulation of endocytosis; regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; macrophage chemotaxis; monocyte chemotaxis; positive chemotaxis; epithelial cell differentiation; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development
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 Research Articles on LGALS3    1. Data show that nucleolin and endogenous galectin-3 exist in the same complexes in the nucleolus, the cytoplasm, and on the cell surface of melanoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LGALS3 antibodyPathways associated with anti-LGALS3 antibody
 Reference Product  PubMed Publications
 LGALS3BP antibody  >44 publications with LGALS3 and LGALS3BP
 MMP2 antibody  >7 publications with LGALS3 and MMP2
 GEMIN4 antibody  >5 publications with LGALS3 and GEMIN4
 TNC antibody  >4 publications with LGALS3 and TNC
 PRKCSH antibody  >2 publications with LGALS3 and PRKCSH
 DDOST antibody  >2 publications with LGALS3 and DDOST
 NRAS antibody  >2 publications with LGALS3 and NRAS
 HRAS antibody  >2 publications with LGALS3 and HRAS
 PTPRC antibody  >1 publications with LGALS3 and PTPRC
 SUFU antibody  >1 publications with LGALS3 and SUFU
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-LGALS3 antibodyOrgans/Tissues associated with anti-LGALS3 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >556 publications with LGALS3 and Carcinoma
 Inflammation Antibodies  >295 publications with LGALS3 and Inflammation
 Adenocarcinoma Antibodies  >235 publications with LGALS3 and Adenocarcinoma
 Fibrosis Antibodies  >183 publications with LGALS3 and Fibrosis
 Heart Diseases Antibodies  >164 publications with LGALS3 and Heart Diseases
 Disease Models, Animal Antibodies  >163 publications with LGALS3 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >157 publications with LGALS3 and Neoplasm Metastasis
 Adenoma Antibodies  >138 publications with LGALS3 and Adenoma
 Breast Neoplasms Antibodies  >117 publications with LGALS3 and Breast Neoplasms
 Lung Diseases Antibodies  >98 publications with LGALS3 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >636 publications with LGALS3 and Blood
 Thyroid Antibodies  >304 publications with LGALS3 and Thyroid
 Heart Antibodies  >247 publications with LGALS3 and Heart
 Vascular Antibodies  >194 publications with LGALS3 and Vascular
 Brain Antibodies  >166 publications with LGALS3 and Brain
 Lung Antibodies  >135 publications with LGALS3 and Lung
 Liver Antibodies  >133 publications with LGALS3 and Liver
 Kidney Antibodies  >132 publications with LGALS3 and Kidney
 Bone Antibodies  >117 publications with LGALS3 and Bone
 Muscle Antibodies  >103 publications with LGALS3 and Muscle
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