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anti-GIP antibody :: Mouse anti-Human Gastric Inhibitory Polypeptide Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601881 anti-GIP antibody
Unit / Price
0.1 mL  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gastric Inhibitory Polypeptide (GIP), Monoclonal Antibody

 Also Known As   

Gastric Inhibitory Polypeptide (GIP)

 Product Synonym Names    Anti -Gastric Inhibitory Polypeptide (GIP)
 Product Gene Name   

anti-GIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (47035918..47045955, complement). Location: 17q21.3-q22
 OMIM    137240
 3D Structure    ModBase 3D Structure for P09681
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    6F106
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Gastric Inhibitory Polypeptide (GIP). Binds free GIP in solution. Crossreacts up to 10% with PACAP and human GLP-2. < 0.1% crossreactivity with glucagon, GLP-1 and VIP.
 Purity/Purification    Affinity Purified
Purified by Protein A/G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. Also available without azide. See G2019F1.
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 Immunogen    Synthetic human gastric inhibitory polypeptide
 Culture Medium    RPMI 1640 with 10% fetal calf serum
 Hybridoma    Sp2/mIL-6 myeloma cells with spleen cells from NMRI x Balb/c mice.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-GIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GIP antibody

   Human gastric inhibitory polypeptide (GIP) is a 42aa peptide belonging to the glucagon-secretin family of peptide hormones. It is secreted by endocrine cells in the duodenal mucosa and stimulates glucose-dependent insulin secretion as well as GLP-1 release from more distal endocrine (L) cells in the intestinal mucosa. GIP shows amino-acid sequence similarities to glucagon, GLP-1 and GLP-2 (from ~50% identity for glucagon to 30% identity for GLP-2).
 Product Categories/Family for anti-GIP antibody    Antibodies; Abs to Hormones, Steroids
 Applications Tested/Suitable for anti-GIP antibody   

ELISA (EL/EIA), Immunohistochemistry (IHC)

 Application Notes for anti-GIP antibody    Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:2000; Using glutaraldehyde-linked GIP-OA (molar ratio 4:1) coated at 1ug/ml (or GIP coated directly at 2ug/ml). G2019F binds free GIP in solution.
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NCBI/Uniprot data below describe general gene information for GIP. It may not necessarily be applicable to this product.
 NCBI GI #    183213
 NCBI GeneID    2695
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 UniProt Primary Accession #    P09681 [Other Products]
 UniProt Secondary Accession #    Q4VB42; Q6NTD3 [Other Products]
 UniProt Related Accession #    P09681 [Other Products]
 Molecular Weight    17,108 Da [Similar Products]
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 NCBI Official Full Name    gastric inhibitory polypeptide
 NCBI Official Synonym Full Names    gastric inhibitory polypeptide
 NCBI Official Symbol    GIP [Similar Products]
 NCBI Official Synonym Symbols   
GIP
[Similar Products]
 NCBI Protein Information    gastric inhibitory polypeptide; OTTHUMP00000219839; glucose-dependent insulinotropic polypeptide
 UniProt Protein Name    Gastric inhibitory polypeptide
 UniProt Synonym Protein Names   
Glucose-dependent insulinotropic polypeptide
 Protein Family    Gastric inhibitory polypeptide
 UniProt Gene Name    GIP [Similar Products]
 UniProt Entry Name    GIP_HUMAN
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 NCBI Summary for GIP    This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq]
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 UniProt Comments for GIP    GIP: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Belongs to the glucagon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.3-q22

Cellular Component: extracellular space; cell soma; endoplasmic reticulum lumen; extracellular region

Molecular Function: hormone activity

Biological Process: response to drug; response to peptide hormone stimulus; adult locomotory behavior; positive regulation of insulin secretion; female pregnancy; signal transduction; response to amino acid stimulus; sensory perception of pain; response to lipid; endocrine pancreas development; response to organic cyclic substance; memory; response to starvation; response to selenium ion; cellular protein metabolic process; response to glucose stimulus; response to axon injury; regulation of insulin secretion
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 Research Articles on GIP    1. We report that the human GIP locus was differentially selected in East Asians about 8100 years ago based on the analysis of a nonsynonymous SNP (rs2291725).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GIP antibodyPathways associated with anti-GIP antibody
 Reference Product  PubMed Publications
 GIPR antibody  >62 publications with GIP and GIPR
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-GIP antibodyOrgans/Tissues associated with anti-GIP antibody
 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with GIP and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Diabetes Mellitus, Type 2 Antibodies  >311 publications with GIP and Diabetes Mellitus, Type 2
 Obesity Antibodies  >217 publications with GIP and Obesity
 Insulin Resistance Antibodies  >153 publications with GIP and Insulin Resistance
 Neoplasms Antibodies  >144 publications with GIP and Neoplasms
 Mental Disorders Antibodies  >72 publications with GIP and Mental Disorders
 Weight Loss Antibodies  >64 publications with GIP and Weight Loss
 Adenoma Antibodies  >55 publications with GIP and Adenoma
 Diabetes Complications Antibodies  >52 publications with GIP and Diabetes Complications
 Neurologic Manifestations Antibodies  >40 publications with GIP and Neurologic Manifestations
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >399 publications with GIP and Intestine
 Stomach Antibodies  >146 publications with GIP and Stomach
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