NP_036705.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 2A
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon-1
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2A
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A
UniProt Synonym Gene Names
UniProt Entry Name
NMDE1_RAT
NCBI Summary for Grin2a
may play a role in synaptic transmission, learning and memory [RGD, Feb 2006]
UniProt Comments for Grin2a
NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; terminal button; synapse; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: voltage-gated cation channel activity; protein dimerization activity; neurotransmitter binding; glutamate receptor binding; zinc ion binding; calcium channel activity; protein kinase binding; ATPase binding; protein binding; glutamate binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; ionotropic glutamate receptor activity; N-methyl-D-aspartate selective glutamate receptor activity; protein complex binding; cell adhesion molecule binding; cation channel activity; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; positive regulation of apoptosis; rhythmic process; regulation of synaptic plasticity; response to other organism; sensory perception of pain; response to organic cyclic substance; dopamine metabolic process; response to carbohydrate stimulus; synaptic transmission; protein localization; learning and/or memory; calcium ion transport; response to methylmercury; response to wounding; visual learning; locomotion; cation transport; protein tetramerization; serotonin metabolic process; regulation of synaptic transmission; response to drug; synaptic transmission, glutamatergic; response to light stimulus; regulation of action potential; hippocampus development; response to amphetamine; learning; sleep; response to cocaine; memory; response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; regulation of membrane potential; regulation of postsynaptic membrane potential; response to ethanol; neurogenesis; spinal cord development; ionotropic glutamate receptor signaling pathway; directional locomotion; cerebral cortex development; regulation of sensory perception of pain; response to calcium ion; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process; response to amine stimulus
Product References and Citations for anti-Grin2a antibody
1. Teng H.J., et al. (2010) PLoS ONE. 5: e13342.
Research Articles on Grin2a
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Pathways associated with anti-Grin2a antibody
Diseases associated with anti-Grin2a antibody
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