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anti-SLC1A1 antibody :: Mouse anti-Rat Glutamate Transporter Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602774 anti-SLC1A1 antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate Transporter (SLC1A1), Monoclonal Antibody

 Also Known As   

Glutamate Transporter (EAAC1)

 Product Synonym Names    Anti -Glutamate Transporter (EAAC1)
 Product Gene Name   

anti-SLC1A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (4490427..4587469). Location: 9p24
 OMIM    133550
 3D Structure    ModBase 3D Structure for P43005
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2Q72
 Host    Mouse
 Species Reactivity    Rat
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 Specificity    Recognizes Glutamate Transporter EAAC1. Species Crossreactivity: Rat. Does not react well with human
 Purity/Purification    Purified
Purified immunoglobulin.
 Form/Format    Supplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
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 Immunogen    C-terminus peptide KDKSDTISFTQTSQF
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-SLC1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SLC1A1 antibody    Antibodies; Abs to Transport Proteins
 Applications Tested/Suitable for anti-SLC1A1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SLC1A1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry: 1-2ug/ml
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NCBI/Uniprot data below describe general gene information for SLC1A1. It may not necessarily be applicable to this product.
 NCBI GI #    507898
 NCBI GeneID    6505
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 UniProt Primary Accession #    P43005 [Other Products]
 UniProt Secondary Accession #    O75587; Q5VZ24; Q8N199; Q9UEW2 [Other Products]
 UniProt Related Accession #    P43005 [Other Products]
 Molecular Weight    57,100 Da [Similar Products]
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 NCBI Official Full Name    glutamate transporter
 NCBI Official Synonym Full Names    solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
 NCBI Official Symbol    SLC1A1 [Similar Products]
 NCBI Official Synonym Symbols   
EAAC1; EAAT3
[Similar Products]
 NCBI Protein Information    excitatory amino acid transporter 3; OTTHUMP00000021006; excitatory amino acid carrier 1; solute carrier family 1 member 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3
 UniProt Protein Name    Excitatory amino acid transporter 3
 UniProt Synonym Protein Names   
Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
 Protein Family    Excitatory amino acid transporter
 UniProt Gene Name    SLC1A1 [Similar Products]
 UniProt Synonym Gene Names    EAAC1; EAAT3 [Similar Products]
 UniProt Entry Name    EAA3_HUMAN
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 NCBI Summary for SLC1A1    This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq]
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 UniProt Comments for SLC1A1    SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: glutamate binding; cysteine transmembrane transporter activity; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity

Biological Process: synaptic transmission; L-glutamate import; cysteine transport; ion transport; transmembrane transport; protein homooligomerization

Disease: Schizophrenia 18
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 Research Articles on SLC1A1    1. SLC1A1 mutations leading to substitution of arginine to tryptophan at position 445 (R445W) and deletion of isoleucine at position 395 (I395del) cause dicarboxylic aminoaciduria, an autosomal recessive disorder of urinary glutamate and aspartate transport
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC1A1 antibodyPathways associated with anti-SLC1A1 antibody
 Reference Product  PubMed Publications
 ARL6IP5 antibody  >8 publications with SLC1A1 and ARL6IP5
 PRKCA antibody  >3 publications with SLC1A1 and PRKCA
 Products by Pathway  Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
Diseases associated with anti-SLC1A1 antibodyOrgans/Tissues associated with anti-SLC1A1 antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >54 publications with SLC1A1 and Central Nervous System Diseases
 Mental Disorders Antibodies  >33 publications with SLC1A1 and Mental Disorders
 Neoplasms Antibodies  >21 publications with SLC1A1 and Neoplasms
 Epilepsy Antibodies  >18 publications with SLC1A1 and Epilepsy
 Anxiety Disorders Antibodies  >17 publications with SLC1A1 and Anxiety Disorders
 Neurodegenerative Diseases Antibodies  >12 publications with SLC1A1 and Neurodegenerative Diseases
 Seizures Antibodies  >11 publications with SLC1A1 and Seizures
 Schizophrenia Antibodies  >9 publications with SLC1A1 and Schizophrenia
 Neurologic Manifestations Antibodies  >8 publications with SLC1A1 and Neurologic Manifestations
 Ischemic Attack, Transient Antibodies  >8 publications with SLC1A1 and Ischemic Attack, Transient
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >155 publications with SLC1A1 and Brain
 Eye Antibodies  >21 publications with SLC1A1 and Eye
 Kidney Antibodies  >21 publications with SLC1A1 and Kidney
 Intestine Antibodies  >13 publications with SLC1A1 and Intestine
 Muscle Antibodies  >7 publications with SLC1A1 and Muscle
 Liver Antibodies  >4 publications with SLC1A1 and Liver
 Embryonic Tissue Antibodies  >4 publications with SLC1A1 and Embryonic Tissue
 Vascular Antibodies  >4 publications with SLC1A1 and Vascular
 Uterus Antibodies  >3 publications with SLC1A1 and Uterus
 Testis Antibodies  >3 publications with SLC1A1 and Testis
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