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anti-GnRHR antibody :: Mouse anti-Human GnRHR GnRHR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531582 anti-GnRHR antibody
Unit / Price
1 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GnRHR, Monoclonal Antibody

 Also Known As   

GnRHR antibody

 Product Synonym Names    Monoclonal GnRHR; Anti-GnRHR; Gonadotropin Releasing Hormone Receptor
 Product Gene Name   

anti-GnRHR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138850
 3D Structure    ModBase 3D Structure for P30968
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    M0201127
 Host    Mouse
 Species Reactivity    Human GnRHR
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 Form/Format    PBS, pH 7.5, with 0.1% NaN3.
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 Biological Significance    The gonadotropin-releasing hormone receptor (GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    GnRHR antibody was raised in mouse using highly pure human gonadotropin releasing hormone receptor as the immunogen.
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE.
 Other Notes    Small volumes of anti-GnRHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GnRHR antibody

   Mouse monoclonal GnRHR antibody
 Product Categories/Family for anti-GnRHR antibody    Hormones & Steroids
 Applications Tested/Suitable for anti-GnRHR antibody   

Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for GnRHR. It may not necessarily be applicable to this product.
 NCBI GI #    957293
 NCBI GeneID    2798
 NCBI Accession #    AAB33884.1 [Other Products]
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 UniProt Primary Accession #    P30968 [Other Products]
 UniProt Secondary Accession #    O75793; Q14D13; Q92644 [Other Products]
 UniProt Related Accession #    P30968 [Other Products]
 Molecular Weight    27,727 Da
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 NCBI Official Full Name    gonadotropin releasing hormone receptor, partial
 NCBI Official Synonym Full Names    gonadotropin-releasing hormone receptor
 NCBI Official Symbol    GNRHR [Similar Products]
 NCBI Official Synonym Symbols   
HH7; GRHR; LRHR; LHRHR; GNRHR1
[Similar Products]
 NCBI Protein Information    gonadotropin-releasing hormone receptor
 UniProt Protein Name    Gonadotropin-releasing hormone receptor
 Protein Family    Gonadotropin-releasing hormone receptor
 UniProt Gene Name    GNRHR [Similar Products]
 UniProt Synonym Gene Names    GRHR; GnRH receptor; GnRH-R [Similar Products]
 UniProt Entry Name    GNRHR_HUMAN
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 NCBI Summary for GnRHR    This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GnRHR    GNRHR: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in GNRHR are a cause of fertile eunuch syndrome (FEUNS). Fertile eunuch syndrome is a mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: gonadotropin-releasing hormone receptor activity; peptide binding

Biological Process: G-protein coupled receptor protein signaling pathway; multicellular organismal development

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
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 Research Articles on GnRHR    1. Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GnRHR antibodyPathways associated with anti-GnRHR antibody
 Reference Product  PubMed Publications
 GNRH1 antibody  >35 publications with GnRHR and GNRH1
 KISS1R antibody  >29 publications with GnRHR and KISS1R
 PROK2 antibody  >23 publications with GnRHR and PROK2
 TAC3 antibody  >20 publications with GnRHR and TAC3
 KISS1 antibody  >18 publications with GnRHR and KISS1
 GNRH2 antibody  >9 publications with GnRHR and GNRH2
 TRHR antibody  >3 publications with GnRHR and TRHR
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-GnRHR antibodyOrgans/Tissues associated with anti-GnRHR antibody
 Disease Name  Pubmed Publications
 Gonadal Disorders Antibodies  >119 publications with GnRHR and Gonadal Disorders
 Hypogonadism Antibodies  >109 publications with GnRHR and Hypogonadism
 Urogenital Abnormalities Antibodies  >32 publications with GnRHR and Urogenital Abnormalities
 Disorders of Sex Development Antibodies  >29 publications with GnRHR and Disorders of Sex Development
 Ovarian Diseases Antibodies  >27 publications with GnRHR and Ovarian Diseases
 Nervous System Diseases Antibodies  >23 publications with GnRHR and Nervous System Diseases
 Genital Diseases, Male Antibodies  >22 publications with GnRHR and Genital Diseases, Male
 Infertility, Female Antibodies  >18 publications with GnRHR and Infertility, Female
 Infertility, Male Antibodies  >17 publications with GnRHR and Infertility, Male
 Breast Neoplasms Antibodies  >17 publications with GnRHR and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Pituitary Gland Antibodies  >124 publications with GnRHR and Pituitary Gland
 Adrenal Gland Antibodies  >6 publications with GnRHR and Adrenal Gland
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