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anti-GZMB antibody :: Mouse Granzyme B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531585 anti-GZMB antibody
Unit / Price
0.1 mg  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Granzyme B (GZMB), Monoclonal Antibody

 Also Known As   

Granzyme B antibody (PE)

 Product Synonym Names    Monoclonal Granzyme B; Anti-Granzyme B
 Product Gene Name   

anti-GZMB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123910
 3D Structure    ModBase 3D Structure for P10144
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    CLB-GB11
 Host    Mouse
 Species Reactivity    This antibody recognizes the Granzyme B antigen, which is expressed in Human, chimpanzee and Rhesus Monkeys
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 Specificity    Human granzyme B
 Form/Format    Supplied as a liquid in PBS with 0.1% NaN3.
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 Biological Significance    Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    PE
 Immunogen    Granzyme B antibody (PE) was raised in mouse using human granzyme B as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-GZMB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GZMB antibody

   Mouse monoclonal Granzyme B antibody (PE)
 Product Categories/Family for anti-GZMB antibody    Proteases, Inhibitors, & Enzymes; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-GZMB antibody   

User optimized

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NCBI/Uniprot data below describe general gene information for GZMB. It may not necessarily be applicable to this product.
 NCBI GI #    221625528
 NCBI GeneID    3002
 NCBI Accession #    NP_004122.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004131.4 [Other Products]
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 UniProt Primary Accession #    P10144 [Other Products]
 UniProt Secondary Accession #    Q8N1D2; Q9UCC1 [Other Products]
 UniProt Related Accession #    P10144 [Other Products]
 Molecular Weight    27,716 Da [Similar Products]
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 NCBI Official Full Name    granzyme B
 NCBI Official Synonym Full Names    granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 NCBI Official Symbol    GZMB [Similar Products]
 NCBI Official Synonym Symbols   
HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
[Similar Products]
 NCBI Protein Information    granzyme B
 UniProt Protein Name    Granzyme B
 UniProt Synonym Protein Names   
C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
 Protein Family    Granzyme
 UniProt Gene Name    GZMB [Similar Products]
 UniProt Synonym Gene Names    CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP [Similar Products]
 UniProt Entry Name    GRAB_HUMAN
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 NCBI Summary for GZMB    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GZMB    GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Protease; EC 3.4.21.79; Apoptosis

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: intracellular membrane-bound organelle; membrane; cytoplasm; immunological synapse; nucleus; cytosol

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: Notch signaling pathway; induction of apoptosis by granzyme; natural killer cell mediated cytotoxicity; apoptosis; cytolysis; immune response; protein processing; proteolysis
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 Research Articles on GZMB    1. These results suggest that GZMB Q55R, P94A, and Y247H polymorphisms are not significantly associated with colon cancer incidence, or metastasis to lymph node and distant organ.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GZMB antibodyPathways associated with anti-GZMB antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >147 publications with GZMB and CASP3
 FOXP3 antibody  >82 publications with GZMB and FOXP3
 BID antibody  >62 publications with GZMB and BID
 SERPINB9 antibody  >60 publications with GZMB and SERPINB9
 PRF1 antibody  >38 publications with GZMB and PRF1
 CASP7 antibody  >20 publications with GZMB and CASP7
 IL2RB antibody  >14 publications with GZMB and IL2RB
 IL2 antibody  >6 publications with GZMB and IL2
 CD8A antibody  >1 publications with GZMB and CD8A
 Products by Pathway  Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
Diseases associated with anti-GZMB antibodyOrgans/Tissues associated with anti-GZMB antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >324 publications with GZMB and Necrosis
 Inflammation Antibodies  >220 publications with GZMB and Inflammation
 Disease Models, Animal Antibodies  >133 publications with GZMB and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >106 publications with GZMB and Neoplasms, Experimental
 Lung Diseases Antibodies  >98 publications with GZMB and Lung Diseases
 Liver Diseases Antibodies  >84 publications with GZMB and Liver Diseases
 Hepatitis Antibodies  >56 publications with GZMB and Hepatitis
 Hypersensitivity Antibodies  >51 publications with GZMB and Hypersensitivity
 Brain Diseases Antibodies  >39 publications with GZMB and Brain Diseases
 Breast Neoplasms Antibodies  >36 publications with GZMB and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2211 publications with GZMB and Blood
 Lung Antibodies  >168 publications with GZMB and Lung
 Kidney Antibodies  >152 publications with GZMB and Kidney
 Spleen Antibodies  >145 publications with GZMB and Spleen
 Liver Antibodies  >145 publications with GZMB and Liver
 Bone Marrow Antibodies  >100 publications with GZMB and Bone Marrow
 Heart Antibodies  >95 publications with GZMB and Heart
 Intestine Antibodies  >69 publications with GZMB and Intestine
 Pancreas Antibodies  >34 publications with GZMB and Pancreas
 Uterus Antibodies  >22 publications with GZMB and Uterus
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