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anti-GH antibody :: anti-Human Growth Hormone Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312759 anti-GH antibody
Unit / Price
1 mg  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone Receptor (GH), Monoclonal Antibody

 Also Known As   

MAb to Growth Hormone Receptor

 Product Synonym Names    Growth Hormone (hGH) Receptor
 Product Gene Name   

anti-GH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (42424026..42721926). Location: 5p13-p12
 OMIM    143890
 3D Structure    ModBase 3D Structure for P10912
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    B765M
 Host    Host: Mouse
Source: Ascites
 Species Reactivity    Human
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 Specificity    Growth Hormone (hGH) Receptor
 Purity/Purification    >95% pure (SDS-PAGE). Protein G chromatography
 Form/Format    Purified, Liquid
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 Host Animal    Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.
 Immunogen    Human Growth Hormone (hGH) Receptor conjugated with APP.
 Species Specificity    Recognizes Growth hormone receptor-hormone complex and free Growth hormone receptor.
 Affinity Constant    Not determined
 Buffer    PBS, pH 7.4
 Preservative    NaN3 (0.1% Sodium azide)
 Warning    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2-8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GH antibody

   MAb to Growth Hormone Receptor
Monoclonal Antibody to Human Growth Hormone (hGH) Receptor
 Product Categories/Family for anti-GH antibody    Monoclonal Antibodies to Hormones and Steroids
 Applications Tested/Suitable for anti-GH antibody   

ELISA

 Application Notes for anti-GH antibody    Suitable for use in indirect ELISA.
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NCBI/Uniprot data below describe general gene information for GH. It may not necessarily be applicable to this product.
 NCBI GI #    4262867
 NCBI GeneID    2690
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 UniProt Primary Accession #    P10912 [Other Products]
 UniProt Secondary Accession #    Q9HCX2 [Other Products]
 UniProt Related Accession #    P10912; Q32ZL1; Q9HCW9; Q9NRZ8 [Other Products]
 Molecular Weight    71,500 Da
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 NCBI Official Full Name    growth hormone receptor
 NCBI Official Synonym Full Names    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Official Synonym Symbols   
GHBP
[Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; OTTHUMP00000120020; serum binding protein; somatotropin receptor; growth hormone binding protein
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorCleaved into the following chain:Growth hormone-binding protein; GH-binding protein; GHBP; Alternative name(s):; Serum-binding protein
 Protein Family    Growth hormone receptor
 UniProt Gene Name    GHR [Similar Products]
 UniProt Entry Name    GHR_HUMAN
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 NCBI Summary for GH    This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
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 UniProt Comments for GH    Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway

By similarity.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

Subunit structure: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

By similarity. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation

By similarity. Interacts with ADAM17

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway

By similarity.Isoform 2: Cell membrane; Single-pass type I membrane protein. Note: Remains fixed to the cell membrane and is not internalized.Growth hormone-binding protein: Secreted.

Tissue specificity: Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

Post-translational modification: The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17

By similarity.On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2

By similarity.On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization

Polymorphism: Genetic variation in GHR may act as phenotype modifier in familial hypercholesterolemia [

MIM:143890] patients carrying a mutation in the LDLR gene.

Involvement in disease: Defects in GHR are a cause of Laron syndrome (LARS) [

MIM:262500]. A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.20 Ref.21 Ref.23 Ref.26 Ref.28Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA) [

MIM:604271]. Short stature is defined by a subnormal rate of growth. Ref.19

Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain.
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 Research Articles on GH    1. liver-specific hGHR V1 promoter is regulated by both inhibitory Gfi-1/Gf-1b and stimulatory GAGA response elements
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GH antibodyPathways associated with anti-GH antibody
 Reference Product  PubMed Publications
 JAK2 antibody  >151 publications with GH and JAK2
 PRLR antibody  >48 publications with GH and PRLR
 STAT5B antibody  >48 publications with GH and STAT5B
 STAT3 antibody  >25 publications with GH and STAT3
 STAT5A antibody  >22 publications with GH and STAT5A
 SOCS3 antibody  >16 publications with GH and SOCS3
 IRS1 antibody  >15 publications with GH and IRS1
 SOCS2 antibody  >11 publications with GH and SOCS2
 SOCS1 antibody  >9 publications with GH and SOCS1
 GRB2 antibody  >8 publications with GH and GRB2
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
Diseases associated with anti-GH antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >88 publications with GH and Neoplasms
 Insulin Resistance Antibodies  >81 publications with GH and Insulin Resistance
 Laron Syndrome Antibodies  >66 publications with GH and Laron Syndrome
 Liver Diseases Antibodies  >40 publications with GH and Liver Diseases
 Carcinoma Antibodies  >39 publications with GH and Carcinoma
 Cardiovascular Diseases Antibodies  >37 publications with GH and Cardiovascular Diseases
 Body Weight Changes Antibodies  >36 publications with GH and Body Weight Changes
 Kidney Diseases Antibodies  >31 publications with GH and Kidney Diseases
 Diabetes Mellitus Antibodies  >29 publications with GH and Diabetes Mellitus
 Necrosis Antibodies  >27 publications with GH and Necrosis
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