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| Product Name
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Growth Hormone Releasing Hormone (GHRH), Monoclonal Antibody
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| Also Known As
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Monoclonal Antibody to Growth Hormone Releasing Hormone (GHRH)
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| Product Synonym Names
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GRF; GHRF; Somatocrinin; Growth-Hormone-Releasing Factor; Sermorelin; Somatoliberin
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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L29177 Genomic DNA
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| 3D Structure
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ModBase 3D Structure for P01286
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| Clonality
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Monoclonal
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| Isotype
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IgG1 Kappa
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| Clone Number
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C7
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| Host
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Mouse
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| Species Reactivity
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Human
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| Specificity
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The antibody is a mouse monoclonal antibody raised against GHRH. It has been selected for its ability to recognize GHRH in immunohistochemical staining and western blotting.
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| Purity/Purification
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Protein A + Protein G affinity chromatography
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| Form/Format
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Liquid
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| Concentration
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1mg/mL (lot specific)
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| Immunogen
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Recombinant Growth Hormone Releasing Hormone (GHRH)
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| Buffer Formulation
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0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
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| Conjugated Antibody
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The APC conjugated antibody version of this item is also available as catalog #MBS2042383
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| Preparation and Storage
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Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
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| Other Notes
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Small volumes of anti-GHRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for anti-GHRH antibody
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Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
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| Application Notes for anti-GHRH antibody
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Western Blot: 0.5-5ug/mL
Immunocytochemistry in formalin fixed cells: 5-30ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-30ug/mL
Immunohistochemistry in paraffin section: 5-30ug/mL
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| Western Blot (WB) of anti-GHRH antibody
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(Figure. Western Blot; Sample: Recombinant GHRH, Human.)
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| Immunohistochemistry (IHC) of anti-GHRH antibody
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(Figure. DAB staining on IHC-P; Samples: Human Glioma Tissue.)
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| Immunohistochemistry (IHC) of anti-GHRH antibody
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(Figure. DAB staining on IHC-P; Samples: Human Brain Tissue.)
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TOP
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| NCBI/Uniprot data below describe general gene information for GHRH. It may not necessarily be applicable to this product. |
| NCBI GI #
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296080717
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| NCBI GeneID
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2691
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| NCBI Accession #
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NP_001171660.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001184731.2
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[Other Products]
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| UniProt Primary Accession #
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P01286
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[Other Products]
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| UniProt Secondary Accession #
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Q4KN10; Q5JYR1
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[Other Products]
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| UniProt Related Accession #
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P01286
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[Other Products]
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| Molecular Weight
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12,360 Da
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TOP
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| NCBI Official Full Name
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somatoliberin isoform 2 preproprotein
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| NCBI Official Synonym Full Names
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growth hormone releasing hormone
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| NCBI Official Symbol
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GHRH
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[Similar Products]
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| NCBI Official Synonym Symbols
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GRF; INN; GHRF
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[Similar Products]
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| NCBI Protein Information
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somatoliberin
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| UniProt Protein Name
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Somatoliberin
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| UniProt Synonym Protein Names
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Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin
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| Protein Family
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Somatoliberin
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| UniProt Gene Name
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GHRH
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[Similar Products]
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| UniProt Synonym Gene Names
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GHRF; GRF; GHRH
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[Similar Products]
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| NCBI Summary for GHRH
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This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
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| UniProt Comments for GHRH
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GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component: extracellular region; extracellular space; intracellular; terminal bouton
Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding
Biological Process: adenohypophysis development; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cAMP-mediated signaling; cell-cell signaling; growth hormone secretion; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of growth hormone secretion; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; response to food
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TOP
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| Research Articles on GHRH
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1. GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-GHRH antibody | Pathways associated with anti-GHRH antibody |
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| Diseases associated with anti-GHRH antibody | Organs/Tissues associated with anti-GHRH antibody |
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Antibody 
