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anti-GHRH antibody :: Mouse anti-Human Growth Hormone Releasing Hormone (GHRH) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090593
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $175 +1 FREE 8GB USB
0.2 mg  /  $230 +1 FREE 8GB USB
1 mg  /  $520 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone Releasing Hormone (GHRH), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Growth Hormone Releasing Hormone (GHRH)

 Product Synonym Names    GRF; GHRF; Somatocrinin; Growth-Hormone-Releasing Factor; Sermorelin; Somatoliberin
 Product Gene Name   

anti-GHRH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L29177 Genomic DNA
 3D Structure    ModBase 3D Structure for P01286
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 Clonality    Monoclonal
 Isotype    IgG1 Kappa
 Clone Number    C7
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against GHRH. It has been selected for its ability to recognize GHRH in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Growth Hormone Releasing Hormone (GHRH)
 Buffer Formulation    0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2042383
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-GHRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GHRH antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-GHRH antibody    Western Blot: 0.5-5ug/mL
Immunocytochemistry in formalin fixed cells: 5-30ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-30ug/mL
Immunohistochemistry in paraffin section: 5-30ug/mL
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 Western Blot (WB) of anti-GHRH antibody    (Figure. Western Blot; Sample: Recombinant GHRH, Human.)
anti-GHRH antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GHRH antibody    (Figure. DAB staining on IHC-P; Samples: Human Glioma Tissue.)
anti-GHRH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GHRH antibody    (Figure. DAB staining on IHC-P; Samples: Human Brain Tissue.)
anti-GHRH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GHRH. It may not necessarily be applicable to this product.
 NCBI GI #    296080717
 NCBI GeneID    2691
 NCBI Accession #    NP_001171660.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001184731.2 [Other Products]
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 UniProt Primary Accession #    P01286 [Other Products]
 UniProt Secondary Accession #    Q4KN10; Q5JYR1 [Other Products]
 UniProt Related Accession #    P01286 [Other Products]
 Molecular Weight    12,360 Da
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 NCBI Official Full Name    somatoliberin isoform 2 preproprotein
 NCBI Official Synonym Full Names    growth hormone releasing hormone
 NCBI Official Symbol    GHRH [Similar Products]
 NCBI Official Synonym Symbols   
GRF; INN; GHRF
[Similar Products]
 NCBI Protein Information    somatoliberin
 UniProt Protein Name    Somatoliberin
 UniProt Synonym Protein Names   
Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin
 Protein Family    Somatoliberin
 UniProt Gene Name    GHRH [Similar Products]
 UniProt Synonym Gene Names    GHRF; GRF; GHRH [Similar Products]
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 NCBI Summary for GHRH    This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
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 UniProt Comments for GHRH    GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: extracellular region; extracellular space; intracellular; terminal bouton

Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding

Biological Process: adenohypophysis development; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cAMP-mediated signaling; cell-cell signaling; growth hormone secretion; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of growth hormone secretion; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; response to food
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 Research Articles on GHRH    1. GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GHRH antibodyPathways associated with anti-GHRH antibody
 Reference Product  PubMed Publications
 TRH antibody  >258 publications with GHRH and TRH
 CRH antibody  >157 publications with GHRH and CRH
 POMC antibody  >155 publications with GHRH and POMC
 GHRHR antibody  >58 publications with GHRH and GHRHR
 SST antibody  >35 publications with GHRH and SST
 ADCYAP1 antibody  >24 publications with GHRH and ADCYAP1
 GHSR antibody  >11 publications with GHRH and GHSR
 SCT antibody  >5 publications with GHRH and SCT
 GHRL antibody  >3 publications with GHRH and GHRL
 GCG antibody  >3 publications with GHRH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-GHRH antibodyOrgans/Tissues associated with anti-GHRH antibody
 Disease Name  Pubmed Publications
 Adenoma Antibodies  >210 publications with GHRH and Adenoma
 Insulin Resistance Antibodies  >95 publications with GHRH and Insulin Resistance
 Diabetes Mellitus Antibodies  >84 publications with GHRH and Diabetes Mellitus
 Hyperplasia Antibodies  >62 publications with GHRH and Hyperplasia
 Respiratory Tract Diseases Antibodies  >61 publications with GHRH and Respiratory Tract Diseases
 Weight Gain Antibodies  >59 publications with GHRH and Weight Gain
 Adenocarcinoma Antibodies  >59 publications with GHRH and Adenocarcinoma
 Congenital Abnormalities Antibodies  >56 publications with GHRH and Congenital Abnormalities
 Hypothyroidism Antibodies  >56 publications with GHRH and Hypothyroidism
 Weight Loss Antibodies  >44 publications with GHRH and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >57 publications with GHRH and Lung
 Mixed Antibodies  >30 publications with GHRH and Mixed
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