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anti-GHR antibody :: Growth hormone receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS660032 anti-GHR antibody
Unit / Price
1 mg  /  $575 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth hormone receptor (GHR), Monoclonal Antibody

 Also Known As   

Monoclonal mouse anti-human growth hormone receptor

 Product Gene Name   

anti-GHR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 604271
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 Clonality    Monoclonal
 Isotype    IgG1 for MAbs GhRG7, GhRD5 and GhRG6
 Clone Number    GhRG7, GhRD5, GhRG6
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 Specificity    Both GhR-hormone complex and free GhR.
 Purity/Purification    Chromatography on protein G Sepharose
 Form/Format    PBS, pH 7.4, 0.1 % sodium azide (NaN3)
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 Clone Note    Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with human growth hormone receptor conjugated with APP.
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 Preparation and Storage    4 degree C
 Other Notes    Small volumes of anti-GHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GHR antibody   

Indirect ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for GHR. It may not necessarily be applicable to this product.
 NCBI GI #    4262867
 NCBI GeneID    2690
 NCBI Accession #    AAD15015.1 [Other Products]
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 UniProt Secondary Accession #    Q9HCX2 [Other Products]
 UniProt Related Accession #    P10912 [Other Products]
 Molecular Weight    69,237 Da [Similar Products]
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 NCBI Official Full Name    growth hormone receptor, partial
 NCBI Official Synonym Full Names    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Official Synonym Symbols   
GHBP
[Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein
 Protein Family    Growth hormone receptor
 UniProt Gene Name    GHR [Similar Products]
 UniProt Synonym Gene Names    GH receptor; GH-binding protein; GHBP [Similar Products]
 UniProt Entry Name    GHR_HUMAN
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 NCBI Summary for GHR    This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
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 UniProt Comments for GHR    GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; plasma membrane; integral to membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; growth factor binding; peptide hormone binding; protein kinase binding

Biological Process: succinate metabolic process; oxaloacetate metabolic process; activation of MAPK activity; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; positive regulation of tyrosine phosphorylation of Stat3 protein; 2-oxoglutarate metabolic process; allantoin metabolic process; receptor internalization; creatinine metabolic process; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; citrate metabolic process; valine metabolic process; regulation of multicellular organism growth; endocytosis; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; positive regulation of tyrosine phosphorylation of Stat5 protein; response to cycloheximide; taurine metabolic process

Disease: Hypercholesterolemia, Familial; Laron Syndrome
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 Research Articles on GHR    1. In the Brazilian population, GHR exon 3 polymorphism is a severity-related risk factor for osteoporosis, but does not appear to be associated with disease status.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GHR antibodyPathways associated with anti-GHR antibody
 Reference Product  PubMed Publications
 JAK2 antibody  >173 publications with GHR and JAK2
 STAT5B antibody  >61 publications with GHR and STAT5B
 PRL antibody  >52 publications with GHR and PRL
 STAT3 antibody  >30 publications with GHR and STAT3
 SOCS3 antibody  >21 publications with GHR and SOCS3
 GH1 antibody  >21 publications with GHR and GH1
 SOCS2 antibody  >16 publications with GHR and SOCS2
 IRS1 antibody  >15 publications with GHR and IRS1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-GHR antibodyOrgans/Tissues associated with anti-GHR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >86 publications with GHR and Nervous System Diseases
 Laron Syndrome Antibodies  >81 publications with GHR and Laron Syndrome
 Disease Models, Animal Antibodies  >66 publications with GHR and Disease Models, Animal
 Weight Gain Antibodies  >51 publications with GHR and Weight Gain
 Liver Diseases Antibodies  >50 publications with GHR and Liver Diseases
 Carcinoma Antibodies  >48 publications with GHR and Carcinoma
 Necrosis Antibodies  >35 publications with GHR and Necrosis
 Kidney Diseases Antibodies  >35 publications with GHR and Kidney Diseases
 Inflammation Antibodies  >28 publications with GHR and Inflammation
 Fatty Liver Antibodies  >25 publications with GHR and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >411 publications with GHR and Liver
 Muscle Antibodies  >153 publications with GHR and Muscle
 Brain Antibodies  >131 publications with GHR and Brain
 Kidney Antibodies  >93 publications with GHR and Kidney
 Bone Antibodies  >93 publications with GHR and Bone
 Adipose Tissue Antibodies  >65 publications with GHR and Adipose Tissue
 Ovary Antibodies  >58 publications with GHR and Ovary
 Connective Tissue Antibodies  >57 publications with GHR and Connective Tissue
 Heart Antibodies  >49 publications with GHR and Heart
 Embryonic Tissue Antibodies  >48 publications with GHR and Embryonic Tissue
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