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anti-H6PD antibody :: Mouse anti-Human H6PD Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831251
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H6PD, Monoclonal Antibody

 Also Known As   

H6PD antibody

 Product Synonym Names    Monoclonal H6PD; Anti-H6PD; Hexose-6-Phosphate Dehydrogenase; Glucose 1-Dehydrogenase; DKFZp686A01246; G6PDH; GDH; MGC87643; H6PD; HPD 6; HPD-6
 Product Gene Name   

anti-H6PD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138090
 3D Structure    ModBase 3D Structure for O95479
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    3H5
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    H6PD antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells.
 Immunogen    H6PD antibody was raised in mouse using a full length recombinant protein of human H6PD (NP_004276) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-H6PD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-H6PD antibody

   Mouse monoclonal H6PD antibody
 Product Categories/Family for anti-H6PD antibody    Signal Transduction
 Applications Tested/Suitable for anti-H6PD antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-H6PD antibody    FC: 1:100
IF: 1:100
WB: 1:1000
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 Western Blot (WB) of anti-H6PD antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant H6PD protein (Right) or empty vector (Left) detected with H6PD antibody
anti-H6PD antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-H6PD antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant H6PD protein using H6PD antibody
anti-H6PD antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for H6PD. It may not necessarily be applicable to this product.
 NCBI GI #    52145310
 NCBI GeneID    9563
 NCBI Accession #    NP_004276 [Other Products]
 NCBI GenBank Nucleotide #    NM_004285.3 [Other Products]
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 UniProt Primary Accession #    O95479 [Other Products]
 UniProt Secondary Accession #    Q4TT33; Q66I35; Q68DT3 [Other Products]
 UniProt Related Accession #    O95479 [Other Products]
 Molecular Weight    88,893 Da
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 NCBI Official Full Name    GDH/6PGL endoplasmic bifunctional protein isoform 2
 NCBI Official Synonym Full Names    hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
 NCBI Official Symbol    H6PD [Similar Products]
 NCBI Official Synonym Symbols   
GDH; G6PDH; CORTRD1
[Similar Products]
 NCBI Protein Information    GDH/6PGL endoplasmic bifunctional protein
 UniProt Protein Name    GDH/6PGL endoplasmic bifunctional protein
 UniProt Synonym Protein Names   
Glucose 1-dehydrogenase (EC:1.1.1.47)Alternative name(s):Hexose-6-phosphate dehydrogenase
 Protein Family    GDH/6PGL endoplasmic bifunctional protein
 UniProt Gene Name    H6PD [Similar Products]
 UniProt Synonym Gene Names    GDH; 6PGL [Similar Products]
 UniProt Entry Name    G6PE_HUMAN
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 NCBI Summary for H6PD    There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for H6PD    H6PD: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. Defects in H6PD are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

Protein type: Oxidoreductase; Hydrolase; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.1.31; EC 1.1.1.47

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: endoplasmic reticulum lumen

Molecular Function: glucose-6-phosphate dehydrogenase activity; 6-phosphogluconolactonase activity; glucose 1-dehydrogenase activity; NADP binding

Biological Process: pentose-phosphate shunt; glucose metabolic process

Disease: Cortisone Reductase Deficiency 1
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 Research Articles on H6PD    1. The aim of the work was to investigate the expression of HSD11B1, HSD11B2, H6PDH, and glucocorticoids receptor (GR) mRNA in subcutaneous adipose tissue (SAT) from obese women with or without polycystic ovary syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-H6PD antibodyPathways associated with anti-H6PD antibody
 Reference Product  PubMed Publications
 G6PD antibody  >4 publications with H6PD and G6PD
 PGD antibody  >1 publications with H6PD and PGD
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P antibodies  Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P Diagram
 Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P antibodies  Pentose Phosphate Pathway, Oxidative Phase, Glucose 6P => Ribulose 5P Diagram
Diseases associated with anti-H6PD antibodyOrgans/Tissues associated with anti-H6PD antibody
 Disease Name  Pubmed Publications
 Cortisone reductase deficiency Antibodies  >11 publications with H6PD and Cortisone reductase deficiency
 Nervous System Diseases Antibodies  >3 publications with H6PD and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with H6PD and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with H6PD and Necrosis
 Atherosclerosis Antibodies  >1 publications with H6PD and Atherosclerosis
 Hypertension Antibodies  >1 publications with H6PD and Hypertension
 Fatty Liver Antibodies  >1 publications with H6PD and Fatty Liver
 Breast Neoplasms Antibodies  >1 publications with H6PD and Breast Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with H6PD and Prenatal Exposure Delayed Effects
 Inflammation Antibodies  >1 publications with H6PD and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with H6PD and Liver
 Ovary Antibodies  >8 publications with H6PD and Ovary
 Blood Antibodies  >5 publications with H6PD and Blood
 Connective Tissue Antibodies  >5 publications with H6PD and Connective Tissue
 Adrenal Gland Antibodies  >3 publications with H6PD and Adrenal Gland
 Brain Antibodies  >3 publications with H6PD and Brain
 Vascular Antibodies  >2 publications with H6PD and Vascular
 Muscle Antibodies  >2 publications with H6PD and Muscle
 Pancreas Antibodies  >1 publications with H6PD and Pancreas
 Eye Antibodies  >1 publications with H6PD and Eye
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