NP_060015
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,924 Da
NCBI Official Full Name
hydroxyacid oxidase 1
NCBI Official Synonym Full Names
hydroxyacid oxidase (glycolate oxidase) 1
NCBI Protein Information
hydroxyacid oxidase 1
UniProt Protein Name
Hydroxyacid oxidase 1
UniProt Synonym Protein Names
Glycolate oxidase; GOX
UniProt Synonym Gene Names
UniProt Entry Name
HAOX1_HUMAN
NCBI Summary for HAO1
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
UniProt Comments for HAO1
HAO1: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Oxidoreductase; EC 1.1.3.15
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: peroxisomal matrix; peroxisome
Molecular Function: glycolate oxidase activity; FMN binding; glyoxylate oxidase activity; (S)-2-hydroxy-acid oxidase activity; receptor binding
Biological Process: glyoxylate metabolic process; response to oxidative stress; glycolate catabolic process; fatty acid alpha-oxidation
Research Articles on HAO1
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Pathways associated with anti-HAO1 antibody
Diseases associated with anti-HAO1 antibody
Organs/Tissues associated with anti-HAO1 antibody
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