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anti-HAS1 antibody :: Mouse anti-Human HAS1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850949
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAS1, Monoclonal Antibody

 Also Known As   

HAS1 Antibody

 Product Synonym Names    HAS; HAS1
 Product Gene Name   

anti-HAS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601463
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 Clonality    Monoclonal
 Clone Number    3E10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human HAS1 expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-HAS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HAS1 antibody

   Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.
 Product Categories/Family for anti-HAS1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-HAS1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-HAS1 antibody    WB: 1/500 - 1/2000, IHC: 1/200-1/1000, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Western Blot of anti-HAS1 antibody    Western blot analysis using HAS1 mouse mAb against recombinant protein of human HAS1 (aa70-243).
anti-HAS1 antibody Western Blot (WB) image
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 Immunofluorescence of anti-HAS1 antibody    Immunofluorescence analysis of U251 cells using HAS1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
anti-HAS1 antibody Immunofluorescence image
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NCBI/Uniprot data below describe general gene information for HAS1. It may not necessarily be applicable to this product.
 NCBI GI #    167466171
 NCBI GeneID    3036
 NCBI Accession #    NP_001514.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001523.3 [Other Products]
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 UniProt Secondary Accession #    Q14470; Q9NS49 [Other Products]
 UniProt Related Accession #    Q92839 [Other Products]
 Molecular Weight    65kDa
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 NCBI Official Full Name    hyaluronan synthase 1 isoform 1
 NCBI Official Synonym Full Names    hyaluronan synthase 1
 NCBI Official Symbol    HAS1 [Similar Products]
 NCBI Official Synonym Symbols   
HAS
[Similar Products]
 NCBI Protein Information    hyaluronan synthase 1; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1
 UniProt Protein Name    Hyaluronan synthase 1
 UniProt Synonym Protein Names   
Hyaluronate synthase 1; Hyaluronic acid synthase 1; HA synthase 1; HuHAS1
 Protein Family    Hyaluronan synthase
 UniProt Gene Name    HAS1 [Similar Products]
 UniProt Synonym Gene Names    HAS; HA synthase 1; HuHAS1 [Similar Products]
 UniProt Entry Name    HYAS1_HUMAN
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 NCBI Summary for HAS1    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for HAS1    HAS1: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Belongs to the NodC/HAS family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Transferase; Membrane protein, multi-pass; EC 2.4.1.212; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: hyaluronan synthase activity

Biological Process: glycosaminoglycan biosynthetic process; extracellular polysaccharide biosynthetic process; glycosaminoglycan metabolic process; hyaluronan biosynthetic process; carbohydrate metabolic process; pathogenesis; cell adhesion; hyaluronan metabolic process
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 Research Articles on HAS1    1. HAS1 is the main enzyme responsible for hyaluronan production by normal keratinocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HAS1 antibodyDiseases associated with anti-HAS1 antibody
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Biosynthesis And Export Pathway antibodies  Hyaluronan Biosynthesis And Export Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >29 publications with HAS1 and Inflammation
 Necrosis Antibodies  >25 publications with HAS1 and Necrosis
 Cardiovascular Diseases Antibodies  >19 publications with HAS1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >9 publications with HAS1 and Atherosclerosis
 Neoplasm Invasiveness Antibodies  >8 publications with HAS1 and Neoplasm Invasiveness
 Adenocarcinoma Antibodies  >7 publications with HAS1 and Adenocarcinoma
 Hyperplasia Antibodies  >7 publications with HAS1 and Hyperplasia
 Ovarian Neoplasms Antibodies  >6 publications with HAS1 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >6 publications with HAS1 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >6 publications with HAS1 and Prostatic Neoplasms
Organs/Tissues associated with anti-HAS1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >27 publications with HAS1 and Bone
 Connective Tissue Antibodies  >16 publications with HAS1 and Connective Tissue
 Brain Antibodies  >9 publications with HAS1 and Brain
 Ovary Antibodies  >8 publications with HAS1 and Ovary
 Adipose Tissue Antibodies  >2 publications with HAS1 and Adipose Tissue
 Intestine Antibodies  >1 publications with HAS1 and Intestine
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